Elevated low-density lipoprotein-cholesterol in women with polycystic ovary syndrome

Gynecological Endocrinology

Volumn 10, Issue 5, 1996, Pages 311-318

  Von Eckardstein, S ^a   Von Eckardstein, A ^b   Bender, H G ^a   Schulte, H ^b   Assmann, G ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Cardiovascular risk factors; High density lipoproteins; Hyperandrogenism; Hypercholesterolemia; Low density lipoproteins; Obesity

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ETHNOLOGY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0029969707     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.3109/09513599609012817     Document Type: Article

References (33)

1. Gorodeski, G. I. and Utian, W. H. (1994) Epidemiology and risk factors of cardiovascular disease in postmenopausal women. In Lobo, R. A. (ed.) Treatment of the Postmenopausal Woman: Basic and Clinical Aspects, pp. 199-221. (New York: Raven Press)
2. Wild, R. A., Grubb, B., Hartz, M. D., van Nort, J. J., Bachman, W. and Bartholomew, M. (1990). Clinical signs of androgen excess as risk factors for coronary artery disease. Fertil. Steril., 54, 255-60
3. Wild, R. A., Painter, P. C., Coulson, P. B., Carruth, B. K. and Ranney, G. B. (1985). Lipoprotein lipid concentrations and cardivascular risk in women with the polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 61, 946-51
4. Wortsman, J. and Soler, N. G. (1982). Abnormalities of fuel metabolism in the polycystic ovary syndrome. Obstet. Gynecol., 60, 342-5
5. Mattson, L. A., Cullberg, G., Hamberger, L., Samsioe, G. and Silverstolpe, G. (1984). Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk for coronary heart disease. Fertil. Steril., 42, 579-84
6. Dahlgren, E., Johannson, S., Lindstedt, G., Knutsson, F., Oden, A., Janson, P. O., Mattson, L. A., Crona, N. and Lundberg, P. A. (1992). Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focussing on natural history and circulating hormones. Fertil. Steril., 57, 505-13
7. Franks, S. (1989). Polycystic ovary syndrome: a changing perspective. Clin. Endocrinol. (Oxf.), 31, 87-120
8. Chang, R. J., Nakamura, R. M., Judd, H. L. and Kaplan, S. A. (1983). Insulin resistance in nonobese patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab., 57, 356-9
9. Dunaif, A., Mandeli, J., Fluhr, H. and Dobrjansky, A. (1988). The impact of obesity on chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 66, 131-9
10. Conway, G. S., Agrawal, R., Betteridge, D. J. and Jacobs, H. S. (1992). Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin. Endocrinol. (Oxf.), 37, 119-25
11. Björntorp, P. (1993). Hyperandrogenicity in women - a prediabetic condition? J. Intern. Med., 234, 579-83
12. Dahlgren, E., Janson, P. O., Johansson, S., Lapidus, L. and Oden, A. (1992). Polycystic ovary syndrome and risk for myocardial infarction: evaluated from a risk factor model based on a prospective population study of women. Acta Obstet. Gynecol. Scand., 71, 599-604
13. Ferriman, D. and Gallwey, J. D. (1961). Clinical assessment of body hair growth in women. J. Clin. Endocrinol. Metab., 21, 1440-7
14. Assmann, G. and Schulte, H. (1992). Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary heart disease (the PROCAM experience). Am. J. Cardiol., 70, 733-7
15. Friedewald, W. T., Levy, R. I. and Fredrickson, D. S. (1972). Estimation of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem., 18, 499-508
16. Sandkamp, M. Tambyrajah, B., Schriewer, H. and Assmann, G. (1988). Simplified turbidimetric determination of apolipoproteins A-I, A-II and B using a microtitre method. J. Clin. Chem. Clin. Biochem., 26, 685-9
17. Sandkamp, M., Funke, H., Schulte, H., Köhler, E. and Assmann, G. (1990). Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age. Clin. Chem., 38, 20-5
18. Hill, J. S. and Pritchard, P. H. (1990). Improved phenotyping of apolipoprotein E: application to population frequency distribution. Clin. Chem., 36, 1871-4
19. 45→Asn). J. Lipid Res., 35, 1431-40
20. International Task Force for the Prevention of Coronary Heart Disease (1992). Prevention of coronary heart disease: scientific background and new clinical guidelines. Nutr. Metab. Cardiovasc. Dis., 2, 113-56
21. Lenzen, H. J., Assmann, G., Buchwalsky, R. and Schulte, H. (1986). Association of apolipoprotein E polymorphism, low density lipoprotein cholesterol and coronary artery disease. Clin. Chem., 32, 778-84
22. Rojanasakul, A., Chailurkit, L., Sirimongkolkasem, R. and Chaturachinda, K. (1988). Serum lipids and lipoproteins in women with polycystic ovarian disease with different body mass index. Int. J. Gynaecol. Obstet., 27, 401-6
23. Kim, H.-J. and Kalkhoff, R. K. (1979). Changes in lipoprotein composition during the menstrual cycle. Metabolism, 28, 663-8
24. Talbott, E., Guzick, D., Clerici, A., Berga, S., Detre, K., Weimer, K. and Kuller, L. (1995). Coronary heart disease risk factors in women with polycystic ovary syndrome. Arterioscler. Thromb. Vasc. Biol., 15, 821-6
25. Holte, J., Bergh, T., Berne, C. and Lithell, H. (1994). Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables. Clin. Endocrinol. (Oxf.), 41, 463-71
26. Clayton, R. N., Ogden, V., Hodgkinson, J., Worswick, L., Rodin, D. A., Dyer, S. and Meade, T. W. (1992). How common are polycystic ovaries in normal women and what is their significance for the fetility of the population? Clin. Endocrinol. (Oxf.), 37, 127-34
27. Conway, G. S., Clark, P. M., and Wong, D. (1993). Hyperinsulinaemia in the polycystic ovary syndrome confirmed with a specific immunoradiometric assay for insulin. Clin. Endocrinol. (Oxf.), 38, 219-22
28. Graf, M. J., Richards, C. J., Brown, V., Meissner, L. and Dunaif, A. (1990). The independent effects of hyperandrogenaemia, hyperinsulinaemia, and obesity on lipid and lipoprotein profiles in women. Clin. Endocrinol. (Oxf.), 33, 119-31
29. Davignon, J., Gregg, R. E. and Sing, C. F. (1988). Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis, 8, 1-21
30. Dallongeville, J., Lussier-Cacan, S. and Davignon, J. (1992). Modulation of plasma triglyceride levels by apo E phenotype: a meta analysis. J. Lipid Res. 33, 447-54
31. Heller, D. A., de Faire, U., Perdeson, N. L., Dahlen, G. and McClearn, G. E. (1993). Genetic and environmental influences on serum lipid levels in twins. N. Engl. J. Med., 328, 1150-6
32. National Cholesterol Education Program Expert Panel (1988). Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Arch. Intern. Med., 148, 36-69
33. National Institutes of Health (1993). NIH Consensus Development Panel on Triglyceride, High Density Lipoprotein, and Coronary Heart Disease. J. Am. Med. Assoc., 269, 505-10