Defective antibody-mediated opsonisation of S. pneumoniae in high risk patients detected by flow cytometry

Immunology Letters

Volumn 49, Issue 1-2, 1996, Pages 83-89

  Obaro, S K ^a   Henderson, D C ^a   Monteil, M A ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

Flow cytometry; Functional antibody deficiency; Opsonisation; Phagocytosis; Streptococcus pneumoniae

Indexed keywords

ARTICLE; BACTERIAL INFECTION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; IMMUNIZATION; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; RISK; STREPTOCOCCUS PNEUMONIAE;

EID: 0029969644     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-2478(95)02487-5     Document Type: Article

References (21)

1. Johnston, R.B. Jr. (1982) The host response to invasion by Streptococcus pneumoniae: protection and the pathogenesis of tissue damage. In: The Pnuemococcus and the Pneumococcal Vaccine (P.G. Quie and E.H. Kass, Eds.) pp. 100-106. University of Chicago Press, Chicago.
2. Joiner, K.A., Brown, E.J. and Frank, M.M. (1984) Complement and bacteria: chemistry and biology in host defense. Ann. Rev. Immunol. 2, 461-491.
3. Winkelstein, J.A. (1981) The role of complement in the host's defense against Streptococcus pneumoniae. Rev. Infect. Dis. 3, 289-298.
4. Hosea, S.W., Brown, E.J., Hambuger, M.I. and Frank, M.M. (1981) Opsonic requirements for intravascular clearance after splenectomy. N. Engl. J. Med. 304, 246-250.
5. Landesman, S.H. and Schiffman, G. (1981) Assessment of the antibody response to pneumococcal vaccine in high-risk populations. Rev. Infect. Dis. 3 (Suppl.) S184-S197.
6. Braconier, J.H. and Odeberg, H. (1982) Granulocyte phagocytosis and killing of avirulent and virulent serotypes of Streptococcus pneumoniae. J. Lab. Dis. Med. 100, 279-287.
7. Gardner, S.E., Anderson, D.C., Webb, B.J., Stitzel, A.E., Edwards, M.S., Spitzer, R.E. and Baker, C.J. (1982) Evaluation of Streptococcus pneumoniae type XIV Opsonins by phagocytosis associated chemiluminiscence and a bactericidal assay. Infect. Immun. 35, 800-808.
8. Bardardottir, E., Jonsson, S., Jonsdottir, I., Sigfusson, A. and Valdimarsson, H. (1990) IgG subclass response and opsonisation of Streptococcus pneumoniae after vaccination of healthy adults. J. Infect. Dis. 162, 482-488.
9. Smith, T., Lehman, D., Montgomery, J., Gratten, M., Riley, I.D. and Alpers, M.P. (1993) Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children. Epidemiol. Infect. 111, 27-39.
10. Austrian, R. (1989) Pneumococcal polysaccharide vaccines. Rev. Infect. Dis. 2 (Suppl.) 3, S598-S602.
11. Klugman, K.P., Koornhof, H.J., Wasas, A., Storey, K. and Gilbertson, I. (1986) Carriage of penicillin resistant pneumococci. Arch. Dis. Child. 61, 377-381.
12. Sveum, R.J., Chused, T.M., Frank, M.M. and Brown, E.J. (1986) A quantitative fluorescent method for measurement of bacterial adherence and phagocytosis. J. Immunol. Methods 90, 257-264.
13. Boyum, A. (1974) Separation of blood leukocytes, granulocytes and lymphocytes. Tissue Antigens 4, 269-274.
14. Lortan, J.E., Kaniuk, A. StC and Monteil, M.A. (1993) Relationship of in vitro phagocytosis of serotype 14 Streptococcus pneumoniae to specific class and IgG subclass antibody levels in healthy adults. Clin. Exp. Immunol. 91, 54-57.
15. Giebink, G.S., Verhoef, J., Peterson, P.K. and Quie, P.G. (1977) Opsonic requirements for phagocytosis of Streptococcus pneumoniae types VI, XVIII, XXIII, XXV. Infect Immun. 18, 291-297.
16. Kaniuk, A. StC, Lortan, J.E. and Monteil, M.A. (1992) Specific IgG subclass antibody levels and phagocytosis of serotype 14 pneumococcus following immunization. Scand. J. Immunol. 36 (Suppl.) 11, 96-98.
17. Schmitt, M., Keller, H.U. and Cottier, H. (1986) Qualitative and quantitative assessment of human polymorpholeukocyte functions. Beitr. Infusionther. Klin Ernahr. 15, 196-230.
18. Bredius, R.G.M., de Vries, C.E.E., Troelstra, A., van Alphen, L., Weening, R.S., van de Winkel, J.G.J. and Out, T.A. (1993) Phagocytosis of Staphylococcus aureus and Haemophilus influenzae type B opsonised with polyclonal IgG1 and IgG2 antibodies. Functional hFcγRIIa polymorphism to IgG2. J. Immunol. 151, 1463-1472.
19. Musher, D.M., Luchi, M.J., Watson, D.A., Hamilton, R. and Baugh, R.E. (1990) Pneumococcal polysaccharide vaccine in young adults and older bronchitics: determination of IgG responses by ELISA and the effect of adsorption with non-type specific cell wall polysaccharide. J. Infect. Dis. 161, 728-735.
20. Overturf, G.D., Field, R. and Edmonds, R. (1979) Death from type 6 pneumococcal septicaemia in a vaccinated child with sickle cell disease. N. Engl. J. Med. 300, 143.
21. George, R.C. (1994) The epidemiology of pneumococcal disease. In: The Clinical Impact of Pneumococcal Disease and Strategies for its Prevention. (R.T. Mayon-White, Ed.) pp. 1-7, Int. Con. Symp. 210, RSM Press.