Capsaicin-sensitive sensory neurons are involved in bicarbonate secretion induced by lansoprazole, a proton pump inhibitor, in rats

Digestive Diseases and Sciences

Volumn 41, Issue 4, 1996, Pages 785-790

  Inada, Ikuko ^a   Satoh, Hiroshi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

bicarbonate secretion; capsaicin sensitive sensory neurons; lansoprazole; proton pump inhibitor; vasoactive intestinal peptide

Indexed keywords

BICARBONATE; CAPSAICIN; FAMOTIDINE; LANSOPRAZOLE; OMEPRAZOLE; PROTON PUMP INHIBITOR; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DUODENUM; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ANIMALS; ANTI-ULCER AGENTS; BICARBONATES; CAPSAICIN; DUODENUM; FAMOTIDINE; H(+)-K(+)-EXCHANGING ATPASE; HISTAMINE H2 ANTAGONISTS; INTESTINAL MUCOSA; MALE; NEURONS, AFFERENT; OMEPRAZOLE; PROTON PUMPS; RATS; RATS, SPRAGUE-DAWLEY; STIMULATION, CHEMICAL; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0029969571     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02213135     Document Type: Article

References (33)

1. Wallace JL, Bell CJ: Gastroduodenal mucosal defense. Curr Opin Gastroenterol 9:902-908, 1993
2. 2, and inhibition of endogenous prostaglandin synthesis on proximal duodenal bicarbonate secretion in unanesthetized rat. Gastroenterology 88:303-307, 1985
3. Takeuchi K, Matsumoto J, Ueshima K, Okabe S: Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum. Gastroenterology 101:954-961, 1991
4. Scheiman JM, Kraus ER, Boland CR: Regulation of canine gastric mucin synthesis and phospholipid secretion by acid secretagogues. Gastroenterology 103:1842-1850, 1992
5. Matsumoto J, Takeuchi K, Ueshima K, Okabe S: Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants. Dig Dis Sci 37:1336-1344, 1992
6. Feil W, Klimesch S, Karner P, Wenzi E, Starlinger M, Lacy ER, Schiessel R: Importance of an alkaline microenvironment for rapid restitution of the rabbit duodenal mucosa in vitro. Gastroenterology 97:112-122, 1989
7. - and mucosal restitution. J Int Med 228(suppl 1):59-62, 1990
8. Ballesteros MA, Wolosin JD, Hogan DL, Koss MA, Isenberg JI: Cholinergic regulation of human proximal duodenal mucosal bicarbonate secretion. Am J Physiol 261:G327-G331, 1991
9. Flemström G, Säfsten B: Role of dopamine and other stimuli of mucosal bicarbonate secretion in duodenal protection. Dig Dis Sci 39:1839-1842, 1994
10. - transport in vitro: Effects of hormones and local transmitters. Am J Physiol 242:G100-G110, 1982
11. Buck SH, Burks TF: The neuropharmacology of capsaicin: Review of some recent observations. Pharmacol Rev 38:179-226, 1986
12. Holzer P, Pabst MA, Lippe IT, Peskar BM, Peskar BA, Livingston EH, Guth PH: Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Gastroenterology 98:838-848, 1990
13. Satoh H, Inatomi N, Nagaya H, Inada I, Nohara A, Nakamura N, Maki Y: Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J Pharmacol Exp Ther 248:806-815, 1989
14. Inatomi N, Nagaya H, Takami K, Shino A, Satoh H: Effects of a proton pump inhibitor, AG-1749 (lansoprazole), on reflux esophagitis and experimental ulcers in rats. Jpn J Pharmacol 55:437-451, 1991
15. Isenberg JI, Selling JA, Hogan DL, Koss MA: Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 316:374-379, 1987
16. 2 release and mucosal bicarbonate secretion are altered in patients with duodenal ulcer. Gastroenterology 99:951-955, 1990
17. 2 release and bicarbonate output secondary to a defective duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. Gastroenterology 104:A-146, 1993 (abstract)
18. Holzer P, Sametz W: Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons. Gastroenterology 91:975-981, 1986
19. Maggi CA, Evangelista S, Abelli L, Somma V, Meli A: Capsaicin-sensitive mechanisms and experimentally induced duodenal ulcers in rats. J Pharm Pharmacol 39:559-561, 1987
20. Takeuchi K, Matsumoto J, Ueshima K, Ohuchi T, Okabe S: Induction of duodenal ulcers in sensory deafferented rats following histamine infusion. Digestion 51:203-210, 1942
21. Takeuchi K, Ueshima K, Ohuchi T, Okabe S: The role of capsaicin-sensitive sensory neurons in healing of HC1-induced gastric mucosal lesions in rats. Gastroenterology 106:1524-1532, 1994
22. 2, vasoactive intestinal peptide, neurokinin A and substance P in the rat. Eur J Gastroenterol Hepatol 1:193-199, 1989
23. 2-, and acid-stimulated duodenal bicarbonate secretion. Am J Physiol 256:G833-G836, 1989
24. Nylander O, Hallgren A, Holm L: Duodenal mucosal alkaline secretion, permeability, and blood flow. Am J Physiol 265:G1029-G1038, 1993
25. Lenz HJ, Forquignon I, Drüge G, Greten H: Effects of neuropeptides on gastric acid and duodenal bicarbonate secretions in freely moving rats. Regul Pept 24:293-300, 1989
26. Mertz-Nielsen A, Hillingsø J, Bukhave K, Rask-Madsen J: Omeprazole increases duodenal bicarbonate secretion in man. Gastroenterology 106:A-138, 1994 (abstract)
27. Guttu K, Røsok B, Gislason H, Fändriks L, Svanes K, Grønbech JE: Gastric bicarbonate secretion, acid secretion, and mucosal blood flow during influence of pentagastrin and omeprazole in the cat. Scand J Gastroenterol 26:431-441, 1991
28. Konturek SJ, Cieszkowski M, Kwiecień N, Konturek J, Tasler J, Bilski J: Effects of omeprazole, a substituted benzimidazole, on gastrointestinal secretions, serum gastrin, and gastric mucosal blood flow in dogs. Gastroenterology 86:71-77, 1984
29. Flemström G, Mattsson H: Effects of omeprazole on gastric and duodenal bicarbonate secretion. Scand J Gastroenterol 21(suppl 118):65-67, 1986
30. Fändriks L, Jönson C: Effects of acute administration of omeprazole or ranitidine on basal and vagally stimulated gastric acid secretion and alkalinization of the duodenum in anaesthetized cats. Acta Physiol Scand 138:181-186, 1940
31. 3 secretion in rat duodenum alter treatment with omeprazole and ranitidine. Scand J Gastroenterol 22:87-90, 1987
32. Dayton MT, Schlegel J: Cimetidine-induced bicarbonate production in canine gastric pouches. J Surg Res 32:464-470, 1982
33. 2-receptor antagonist: Effect on parietal, nonparietal, and pepsin secretion in man. Dig Dis Sci 30:308-312, 1985