1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 4, 1996, Pages 439-440

  Zheng, Hua ^a   Espitia, Stephen A ^b   Ilyin, Victor ^b   Hawkinson, Jon E ^b   Woodward, Richard M ^b   Weber, Eckard ^c   Keana, John F W ^a  

^a UNIVERSITY OF OREGON   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 QUINOXALINEDIONE DERIVATIVE; GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0029969569     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00036-4     Document Type: Article

References (13)

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10. 13 mp dec), CHN; 4b: mp 300°C dec, found m/e 260.9717; 4c: mp 276-278°C, found m/e 323.8685; 4d: mp 283-286°C, CHN; 4e: mp 350°C dec, CHN; 4f: mp 285-288°C, CHN; 4g: mp 300°C dec, found m/e 323.9358; 4h: mp 285-287°C, found m/e 333.8610.
11. Cai, S. X.; Huang, J. C.; Woodward, R.; Hawkinson, J.; Lü, Y.; Zhou, Z. L.; Weber, E.; Keana, J. F. W., manuscript in preparation.
12. Difficulties with synthesis in our hands precluded evaluation of 1-hydroxy-8-substituted NOHQXs.
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