Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium

European Neuropsychopharmacology

Volumn 6, Issue 1, 1996, Pages 39-41

  Patishi, Y ^a   Bersudsky, Y ^a   Belmaker, R H ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Lithium; Phorbol ester; Protein kinase C; Rat behavior

Indexed keywords

LITHIUM; PHORBOL ESTER; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; HIPPOCAMPUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029969483     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0924-977X(95)00054-S     Document Type: Article

References (15)

1. Berridge, M.J. (1989) Inositol trisphosphatase, calcium, lithium und cell signaling. J. Am. Med. Assoc. 262, 1834-1841.
2. + antiporter activity in HL-60 cells. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 188, 193-202.
3. Casebolt, T.L. and Jope, R.S. (1991) Effects of chronic lithium treatment on protein kinase C and cyclic AMP dependent protein phosphorylation. Biol. Psychiatry 25, 329-340.
4. Ebstein, R., Belmaker, R.H., Granhaus, L. and Rimon, R. (1976) Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans. Nature 259, 411-413.
5. Gispen, W.H., Schrama, L.H. and Eichberg, J. (1985) Stimulation of protein kinase C reduces ACTH-induced excessive grooming. Eur. J. Pharmacol. 114, 399-400.
6. Hallcher, L.M. and Sherman, W.R. (1980) The effects of lithium ion and other agents on the activity of myo-inositol-l-phosphatase from bovine brain. J. Biol. Chem. 255, 10896-19901.
7. Kofman, O. and Belmaker, R.H. (1993) Biochemical, behavioral and clinical studies of the role of inositol in lithium treatment and depression. Biol. Psychiatry 34, 839-852.
8. Kow, L.M., Brown, H.E. and Pfaff, D.W. (1994) Activation of protein kinase C in the hypothalamic ventromedial nucleus of the midbrain central gray facilitates lordosis. Brain Res. 660, 241-248.
9. Lenox, R.H. (1988) Lithium interactions with the phosphoinositide system and protein kinase C in the nervous system. In: R.H. Belmaker, M. Sandler and A. Dahlstrom (Eds.), Progress in Catecholamine Research. Alan R. Liss, New York, pp. 327-335.
10. Manji, H.K. and Lenox, R.H. (1994) Long-term action of lithium: a role for transcriptional and posttranscriptional factors regulated by protein kinase C. Synapse 16, 11-28.
11. Manji, H.K., Etcheberrigaray, R., Chen, G. and Olds, J.L. (1993) Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the α isozyme. J. Neurochem. 61, 2303-2310.
12. Nishizuka, Y. (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 108, 693-698.
13. Nishizuka, Y. (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334, 661-665.
14. Smith, S.E. and Meldrum, B.S. (1992) The protein kinase C activators, phorbol 12-myristate, 13-acetate and phorbol 12, 13-dibutyate, are convulsant in the pico-nanomolar range in mice. Eur. J. Pharmacol. 213, 133-135.
15. Wachtel, H., Loschmann, P.A., Schneider, H.H. and Rettig, K.J. (1987) Effects of forskolin on spontaneous behavior, rectal temperature and brain cAMP levels of rats: interaction with rolipram. Neurosci. Lett. 76, 191-196.