Phosphorylation of Okazaki-like DNA fragments in mammalian cells and role of polyamines in the processing of this DNA

EMBO Journal

Volumn 15, Issue 5, 1996, Pages 1193-1200

  Pohjanpelto, Pirkko ^a   Hölttä, Erkki ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

DNA synthesis; Okazaki fragments; Phosphorylation; Polyamines

Indexed keywords

ALKALINE PHOSPHATASE; DEOXYRIBONUCLEOSIDE; DNA FRAGMENT; PHOSPHATE; PHOSPHORUS 32; POLYAMINE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; RIBONUCLEASE A;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DNA MODIFICATION; DNA SYNTHESIS; HYPOTHESIS; MAMMAL CELL; MOLECULAR WEIGHT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA; PROKARYOTA;

EID: 0029968417     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00458.x     Document Type: Article

References (22)

1. Burhans, W.C , Selegue, J.E. and Heintz, N.H. (1986) Replication intermediates formed during initiation of DNA synthesis in methotrexate-resistant CHOC 400 cells are enriched for sequences derived from a specific, amplified restriction fragment. Biochemistry, 25, 441-449.
2. Burhans, W C., Vassilev, L T., Caddle, M.S., Heintz, N.H. and DePamphilis, M.L. (1990) Identification of an origin of bidirectional DNA replication in mammalian chromosomes. Cell, 62, 955-965.
3. DePamphilis, M.L. (1993) Eukaryotic DNA replication: anatomy of an origin. Annu. Rev. Biochem., 62, 29-63.
4. DePamphilis, M.L. and Wassarman, P M. (1980) Replication of eukaryotic chromosomes: a close-up of the replication fork. Annu. Rev. Biochem., 49, 627-666.
5. Heintz, N.H. and Stillman, B.W. (1988) Nuclear DNA synthesis in vitro is mediated via stable replication forte assembled in a temporally specific fashion in vivo. Mol. Cell. Biol., 8, 1923-1931.
6. Höltta, E and Pohjanpelto, P (1986) Control of ornithine decarboxylase in Chinese hamster ovary cells by polyamines. J. Biol. Chem., 261, 9502-9508.
7. Kornberg, A and Baker, T.A. (1992) DNA Replication. Freeman and Co , New York, NY.
8. Levin, C J. and Zimmerman, S.B. (1976) A deoxyribonucleic acid kinase from nuclei of rat liver. Purification and properties. J. Biol. Chem., 251, 1767-1774.
9. Metcalf, B W., Bey, P., Danzin, C., Jung, M.J., Casara, P. and Vevert, J P. (1978) Catalytic irreversible inhibition of mammalian ornithine decarboxylase (EC 4.1.1.17) by substrate and product analogues. J. Am. Chem. Soc., 100, 2551-2553.
10. Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J. (1966) The enzymatic phosphorylation of ribonucleic acid and deoxynbonucleic acid II Further propenies of the 5′-hydroxyl polynucleotide kinase J. Biol. Chem., 241, 2933-2943.
11. Ogawa, T. and Okazaki, T. (1980) Discontinuous DNA replication Annu. Rev. Biochem., 49, 421-457.
12. Oredsson, S.M., Nicander, B. and Heby, O. (1990) Implications for a reduced DNA-elongation rate in polyamine-depleted cells. Eur. J. Biochem., 190, 483-489.
13. Pegg, A.E. and McCann, P.P. (1982) Polyamine metabolism and function. Am. J. Physiol., 243, 212-221.
14. Pohjanpelto, P. (1975) Putrescine shortens the S-period in human fibroblasts. Biomedicine, 23, 350-352.
15. Pohjanpelto, P. and Hölttä, E. (1990) Deprivation of a single ammo acid influences protein synthesis-dependent increases in c-jun, c-myc, and ornithine decarboxylase mRNAs in Chinese hamster ovary cells Mol. Cell. Biol., 10, 5814-5821.
16. Pohjanpelto, P., Hölttä, E. and Jänne, O.A. (1985) Mutant strain of Chinese hamster ovary cells with no detectable ornithine decarboxylase activity. Mol. Cell. Biol., 5, 1385-1390.
17. Pohjanpelto, P., Nordling, S. and Knuutila, S. (1994) Flow cytometric analysis of the cell cycle in polyamine depleted cells. Cytometry, 16, 31-338.
18. Probst, H , Hofstaetter, T., Jenke, H.-S., Gentner, P.R. and Müller-Scholz, D. (1983) Metabolism and non-random occurrence of nonnascent short chains in the DNA of Ehrlich ascites cells. Biochim. Biophys. Acta, 740, 200-211.
19. Tabor, C.W. and Tabor, H. (1984) Polyamines. Annu. Rev. Biochem., 53, 749-790.
20. Tsurimoto, T., Melendy, T. and Stillman, B. (1990) Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin. Nature, 346, 534-539.
21. Waga, S. and Stillman, B. (1994) Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature, 369, 207-212.
22. Waga, S., Bauer, G. and Stillman, B. (1994) Reconstitution of complete SV40 DNA replication with purified replication factors. J. Biol. Chem , 269, 10923-10934