Effects of external pH on binding of external sulfate, 4,4′-dinitro-stilbene-2,2′-disulfonate (DNDS), and chloride to the band 3 anion exchange protein

Journal of General Physiology

Volumn 107, Issue 2, 1996, Pages 293-306

  Liu, Si Qiong June ^a   Ries, Elizabeth ^a   Knauf, Philip A ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DINITRO 2,2' STILBENEDISULFONIC ACID; ANTIPORTER;

ANION EXCHANGE; ARTICLE; BINDING AFFINITY; CELL MEMBRANE TRANSPORT; CELL PH; CHLORIDE TRANSPORT; DISSOCIATION CONSTANT; ENZYME BINDING; HUMAN; HUMAN CELL; TRANSPORT KINETICS;

AMINO ACIDS; ANION EXCHANGE PROTEIN 1, ERYTHROCYTE; BINDING, COMPETITIVE; CHLORIDES; CROSS-LINKING REAGENTS; HUMANS; HYDROGEN-ION CONCENTRATION; IODIDES; KINETICS; STILBENES; SUCCINIMIDES; SULFATES;

EID: 0029968022     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.107.2.293     Document Type: Article

References (35)

1. Aranibar, X., C. Ostermeier, B. Legrum, H. Rüterjans, and H. Passow. 1994. Influence of stilbene disulfonates on the accessibility of the substrate-binding site for anions in the band 3 protein (AEB1). Renal Physiol. Biochem. 17:187-189.
2. Bjerrum, P. J. 1992. The human erythrocyte anion transport protein, band 3. Characterization of exofacial alkaline titratable groups involved in anion binding/translocation. J. Gen. Physiol. 100:301-339.
3. Fröhlich, O. 1982. The external anion binding site of the human erythrocyte anion transporter: DNDS binding and competition with chloride. J. Membr. Biol. 65:111-125.
4. Fröhlich, O., and R. B. Gunn. 1986. Erythrocyte anion transport: the kinetics of a single-site obligatory exchange system. Biochim. Biophys. Acta 864:169-194.
5. Fröhlich, O., and R. B. Gunn. 1987. Interactions of inhibitors on anion transporter of human erythrocyte. Am. J. Physiol. (Cell Physiol.) 252:C153-C162.
6. Fröhlich, O., C. Leibson. and R. B. Gunn. 1983. Chloride net efflux from intact erythrocytes under slippage conditions. Evidence for a positive charge on the anion binding/transport site. J. Gen. Physiol. 81:127-152.
7. Gabler, R. 1978. Electrical Interactions in Molecular Biophysics: An Introduction. Academic Press, New York.
8. Gunn, R. B., and O. Fröhlich. 1979. Asymmetry in the mechanism for anion exchange in human red blood cell membranes. Evidence for reciprocating sites that react with one transported anion at a time. J. Gen. Physiol. 74:351-374.
9. Gunn, R. B., and O. Fröhlich. 1989. Methods and analysis of erythrocyte anion fluxes. in Methods in Enzymology, Vol. 173. S. Fleischer and B. Fleischer, editors. Academic Press, Inc., San Diego, California. 54-80.
10. Jennings, M. L., R. Monaghan, S. M. Douglas, and J. S. Nicknish. 1985. Functions of extracellular lysine residues in the human erythrocyte anion transport protein. J. Gen. Physiol. 86:653-669.
11. Kawano, Y., K. Okubo, F. Tokunaga, T. Miyata, S. Iwanaga, and N. Hamasaki. 1988. Localization of the pyridoxal phosphate binding site at the COOH-terminal region of erythrocyte band 3 protein. J. Biol. Chem. 263:8232-8238.
12. Knauf, P. A., and J. Brahm. 1989. Functional asymmetry of the anion exchange protein, capnophorin: effects on substrate and inhibitor binding. In Methods in Enzymology, Vol. 173. S. Fleischer and B. Fleischer, editors. Academic Press, New York. 432-453.
13. Knauf, P. A., D. Restrepo, S. J. Lin, N. M. Raha, L. J. Spinelli, F.-Y. Law, B. Cronise, R. B. Snyder, and L. Romanow. 1992. Mechanisms of substrate binding, inhibitor binding, and ion translocation in band 3 and band 3-related proteins. In Progress in Cell Research, Vol. 2. E. Bamberg and H. Passow, editors. Elsevier, Amsterdam. 35-44.
14. Knauf, P. A., E. A. Ries, L. A. Romanow, S. Bahar, and E. S. Szekeres. 1993a. DNDS (4,4′-dinitro-stilbene-2.2′-disulfonate) does not act as a purely competitive inhibitor of red blood cell band 3-mediated anion exchange. Biophys. J. 64:A307. (Abstr.)
15. Knauf, P. A., S. Ship, L. Breuer, L. McCulloch, and A. Rothstein. 1978. Asymmetry of the red cell anion exchange system. Different mechanisms of reversible inhibition by N-(4-azido-2-nitrophenyl)-2-ammoethylsulfonate (NAP-taurine) at the inside and outside of the membrane. J. Gen. Physiol 72:607-630.
16. Knauf, P. A., and L. J. Spinelli. 1995. NIP- and NAP-taunne bind to external modifier site of AE1 (band 3). at which iodide inhibits anion exchange. Am. J. Physiol. (Cell Physiol ) 269:CA10-C416.
17. Knauf, P. A., L. J. Spinelli, and N. A. Mann. 1989. Flufenamic acid senses conformation and asymmetry of human erythrocyte band 3 anion transport protein. Am. J. Phisiol. (Cell Physiol.) 257:C277-C289.
18. - exchange at a noncompetitive she that senses band 3 conformation. Am. J. Physiol (Cell Physiol.) 264:C1144-C1154.
19. Ku, C. P., M. L. Jennings, and H. Passow. 1979. A comparison of the inhibitory potency of reversibly acting inhibitors of anion transport on chloride and sulfate movements across the human red blood cell membrane. Biochim. Biophys. Acta. 553:132-141.
20. 35Cl Nuclear magnetic resonance line broadening shows that eosin-5-maleimide does not block the external anion access channel of band 3. Biophys. J. 69:399-408.
21. - flux by eosin-5-maleimide, is not at the transport site. Am. J. Physiol. (Cell Physiol.)264:C1153-C1164.
22. Liu, S. J., Y. Law, and P. A. Knauf. 1996. Effects of external pH on substrate binding, and on the inward chloride translocation rate-constant of band 3. J. Gen. Physiol. 107:271-291.
23. Lux, S. E., K. M. John, R. R. Kopito, and H. F. Lodish. 1989. Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1). Proc. Natl. Acad. Sci. USA. 86:9089-9093.
24. - and sulfate addition to the chloride transporter of human red blood cells. J. Gen. Physiol. 79:87-113.
25. Milanick, M. A., and R. B. Gunn. 1986. Proton inhibition of chloride exchange: asynchrony of band 3 proton and anion transport sites? Am. J Physiol. (Cell Physiol.)250:C955-C969.
26. 2DIDS (4,4′-diisothiocyanodihydrostilbene-2,2′-disulfonic acid) molecule. J. Biol. Chem. 269:1918-1926.
27. Passow, H. 1986. Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane. Rev. Physiol. Biochem. Pharmacol. 103:61-223.
28. Schnell, K. F., S. Gerhardt, and A. Schoppe-Fredenburg. 1977. Kinetic characteristics of the sulfate self-exchange in human red blood cells and red blood cell ghosts. J. Membr. Biol. 30:319-350.
29. - transport site of human red blood cells by a kinetic analysis of the inhibitory effects of a chemical probe. Biochem. Biophys. Acta. 508:357-363.
30. Staros, J. V., and B. P. Kakkad. 1983. Cross-linking and chymotryptic digestion of the extracytoplasmic domain of the anion exchange channel in intact human erythrocytes. J. Membr. Biol. 74:247-254.
31. Tanner, M.J. A., P. Martin, and S. High. 1988. The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence. Biochem. J. 256: 703-712.
32. Wieth, J. O., and P. J. Bjerrum. 1982. Titration of transport and modifier sites in the red cell anion transport system. J. Gen. Physiol. 79:253-282.
33. Wieth, J. O., and P. J. Bjerrum. 1983. Transport and modifier sites in capnophorin, the anion transport protein of the erythrocyte membrane. In Structure and Function of Membrane Proteins. E. Quagliariello and F. Palmieri, editors. Elsevier Science Publishers B.V. 95-106.
34. Wood, P. G. 1992. The anion exchange proteins: homology and secondary structure. In Progress in Cell Science, Vol 2. E. Bamberg and H. Passow, editors. Elsevier Science Publishers, Amsterdam. 325-352.
35. Wood, P. G., H. Müller, M. Sovak, and H. Passow. 1992. Role of Lys 558 and Lys 869 in substrate and inhibitor binding to the murine band 3 protein: A study of the effects of site-directed mutagenesis of the band 3 protein expressed in the oocytes of Xenopus laevis. J. Membr. Biol. 127:139-148.