Evolution and somatic learning in V-region genes

Research in Immunology

Volumn 147, Issue 4, 1996, Pages 202-208

  Perelson, A S ^a   Hightower, R ^b   Forrest, S ^b  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b University of New Mexico   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN;

ALGORITHM; COMPUTER SIMULATION; EVOLUTION; GENE EXPRESSION; IMMUNE SYSTEM; LEARNING; MULTIGENE FAMILY; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION;

EID: 0029967986     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2494(96)87221-X     Document Type: Article

References (8)

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3. Cumano, A. & Rajewsky, K. (1986), Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J., 5, 2459-2468.
4. Farmer, J.D., Packard, N.H. & Perelson, A.S. (1986), Physica, 22D, 187-204.
5. Forrest, S. (1993), Genetic algorithms: principles of natural selection applied to computation. Science, 261, 872-878.
6. Grefenstette, J.J. (1984), GENESIS: A System for Using Genetic Search Procedures, in "Proceedings of a Conference on Intelligent Systems and Machines" (pp. 161-165).
7. Holland, J.H. (1975), Adaptation in natural and artificial systems. The University of Michigan Press, Ann Arbor, MI.
8. Hood, L. & Prahl, J. (1971), The immune system: a model for differentiation in higher organisms. Adv. Immunol., 14, 291-351.