Animal studies on antioxidants

European Journal of Cardiovascular Prevention & Rehabilitation

Volumn 3, Issue 4, 1996, Pages 358-362

  Afridi, Nadim ^a   Keaney, John F ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antioxidants; oxidation; rabbits; vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; N,N' DIPHENYLPHENYLENEDIAMINE; PROBUCOL;

ATHEROGENESIS; ATHEROSCLEROSIS; LIPID OXIDATION; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RABBIT; REVIEW;

ANIMALS; ANTIOXIDANTS; ARTERIOSCLEROSIS; CORONARY DISEASE; DISEASE MODELS, ANIMAL; RABBITS;

EID: 0029967933     PISSN: 17418267     EISSN: 17418275     Source Type: Journal    
DOI: 10.1177/174182679600300404     Document Type: Article

References (42)

1. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL: Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity N Engl J Med 1989, 320: 915–924.
2. Witztum JL, Steinberg D: Role of oxidized low density lipoprotein in atherogenesis J Clin Invest 1991, 88: 1785–1792.
3. Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Ooshima A etal: Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia Proc Natl Acad Sci USA 1987, 84: 5928–5931.
4. Carew TE, Schwenke DC, Steinberg D: Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit Proc Natl Acad Sci USA 1987, 84: 7725–7729. Thefirst study to demonstrate definitively the relationship between probucol treatment and a reduction in the development of atherosclerosis independent of the lipid—lowering effects of the agent.
5. Sasahara M, Raines EW, Chart A, Carew TE, Steinberg D, Wahl PW etal: Inhibition of hyperchoiesterolemia-induced atherosclerosis in the non-human primate by probucol: I. Is the extent of atherosclerosis related to resistance of LDL to oxidation? J Clin Invest 1994, 94: 155–164.
6. Keaney JF Jr., Frei B: Antioxidant protection of low-density lipoprotein and its role in the prevention of atherosclerotic vascular disease In Natural antioxidants in human health and disease. Edited by Frei B. San Diego: Academic Press; 1994: 303–352.
7. Westrope KL, Miller RL, Wilson RB: Vitamin E in a rabbit model of endogenous hypercholesterolemia and atherosclerosis Nutr Reports Intl 1982, 25: 83–88.
8. Williams RJ, Motteram JM, Sharp CH, Gallagher PJ: Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits Atherosclerosis 1992, 94: 153–159.
9. Verlangieri AJ, Bush MJ: Effects of d-alpha-tocopherol supplementation on experimentally induced primate atherosclerosis J Am Coll Nutr 1992, 11: 131–138.
10. Sparrow CP, Doebber TW, Olszewski J, Wu MS, Ventre J, Stevens KA etal: Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N′ diphenyl-phenylenediamine J Clin Invest 1992, 89: 1885–1891.
11. Tangirala RK, Casanada F, Miller E, Witztum JL, Steinberg D, Palinski W: Effect of the antioxidant N,N′-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice Arterio Thromb Vasc Biol 1995, 15: 1625–1630.
12. Retsky KL, Freeman MW, Frei B: Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions J Biol Chem 1993, 268: 1304–1309.
13. Ginter E, Babala J, Cerven J: The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenesis in guinea pigs J Atheroscler Res 1969, 10: 341–352.
14. Zaitsev VF, Myasnikov LA, Kasatkina LV, Lobova NM, Sukasova TI: The effect of ascorbic acid on experimental atherosclerosis Cor Vasa 1964, 6: 19–25.
15. Verlangieri AJ, Jollis TM, Mumma RO: Effects of ascorbic acid and its 2-sulfate on rabbit aortic intimal thickening Blood Vessels 1977, 14: 157–174.
16. Bocan TM, Mueller SB, Brown EQ, Uhlendorf PD, Mazur MJ, Newton RS: Antiatherosclerotic effects of antioxidants are lesion-specific when evaluated in hypercholesterolemia New Zealand white rabbits Exp Mol Pathol 1992, 57: 70–83.
17. Morel DW, de la Llera-Moya M, Friday KE: Treatment of cholesterol-fed rabbits with dietary vitamins E and C inhibits lipoprotein oxidation but not development of atherosclerosis J Nutr 1994, 124: 2123–2130.
18. Esterbauer H, Striegl G, Puhl H, Oberreither S, Rotheneder M, El-Saadani M etal: The role of vitamin E and carotenoids in preventing oxidation of low density lipoprotein Ann NY Acad Sci 1989, 570: 254–267. Alandmark discussion on the antioxidant protection of LDL and the role of α-tocopherol in protecting LDL against copper-mediated oxidation.
19. Burton GW, Ingold KU: Beta-carotene; an unusual type of lipid antioxidant Science 1984, 224: 569–573.
20. Frei B, Gaziano JM: Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation J Lipid Res 1993, 34: 2135–2145.
21. Hatta A, Frei B: Oxidative modification and antioxidant protection of human low density lipoprotein at high and low oxygen partial pressures J Lipid Res 1995, 36: 2383–2393.
22. Gainer JL, Jones JR: The use of crocetin in experimental atherosclerosis Experientia 1975, 31: 548–549.
23. Shaish A, Daugherty A, O'Sullivan F, Schonfeld G, Heinecke JW: Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits J Clin Invest 1995, 96: 2075–2082. Aclear demonstration that protection of LDL against oxidation in ex-vivo assays is neither necessary nor sufficient for prevention of atherosclerosis in a cholesterol-fed rabbit model.
24. Kleinveld HA, Demacker PNM, Stalenhoef AFH: Comparative study on the effect of low-dose vitamin E and probucol on the susceptibility of LDL to oxidation and the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits Arterioscler Thromb 1994, 14: 1386–1391.
25. Fruebis J, Steinberg D, Dresel HA, Carew TA: A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits J Clin Invest 1994, 94: 392–398.
26. Lehr HA, Hübner C, Nolte D, Finckh B, Beiseigel U, Kohlschütter Z etal: Oxidatively modified low density lipoprotein stimulates leukocyte adherence to the microvascular endothelium in vivo Res Exp Med 1991, 191: 85–90.
27. Navab M, Imes SS, Hama SY, Hough GP, Ross LA, Bork RW etal: Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein J Clin Invest 1991, 88: 2039–2046. Thefirst demonstration that tissue-specific effects of these antioxidant compounds may have some beneficial effects.
28. Morel DW, Hessler GM, Chisolm GM: Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid J Lipid Res 1983, 24: 1070–1076.
29. Kugiyama K, Kerns SA, Morrisett JD, Roberts R, Henry PD: Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins Nature 1990, 344: 160–162.
30. Libby P: Molecular basis of the acute coronary syndromes Circulation 1995, 91: 2844–2850. Anexcellent review that covers the major mechanism(s) thought to be responsible for the clinical activity of coronary artery disease.
31. Cybulsky MI, Gimbrone MA Jr: Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis Science 1991, 251: 788–791. Alandmark paper demonstrating that cholesterol feeding in rabbits is associated with activation of the endothelium and the expression of adhesion molecules on the endothelial surface.
32. Lehr HA, Becker M, Marklund SL, Hübner C, Arfors KE, Kohlschütter A etal: Superoxide-dependent stimulation of leukocyte adhesion by oxidatively modified LDL in vivo. Arterioscler Thromb 1992, 12: 824–829.
33. Lehr HA, Frei B, Arfors KE: Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo Proc Natl Acad Sci USA 1994, 91: 7688–7692.
34. Ross R: The pathogenesis of atherosclerosis - an update N Engl J Med 1986, 314: 488–500.
35. Boscoboinik D, Szewczyk A, Azzi A: Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity Arch Biochem Biophys 1991, 286: 264–269.
36. Lafont AM, Chai YC, Cornhill JF Whitlow PL, Howe PH, Chisolm GM: Effect of alpha-tocopherol on restenosis after angioplasty in a model of experimental atherosclerosis J Clin Invest 1995, 95: 1018–1025.
37. Nunes GL, Sgoutas DS, Redden RR, Sigman SR, Grvanis B, King SB III etal: Combinations of vitamins C and E alters the response to coronary balloon injury in the pig Arterioscler Thromb 1995, 15: 156–165.
38. Chin JH, Azhar S, Hoffman BB: Inactivation of endothelium-derived relaxing factor by oxidized lipoproteins J Clin Invest 1992, 89: 10–18.
39. Verbeuren TJ, Jordaens FH, Zonnekeyn LL, VanHove CE, Coene MC, Herman AG: Effect of hypercholesterolemia on vascular reactivity in the rabbit Circ Res 1986, 58: 553–564.
40. Keaney JF Jr., Xu A, Cunningham D, Jackson T, Frei B, Vita JA: Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation J Clin Invest 1995, 95: 2520–2529.
41. Keaney JF Jr., Gaziano JM, Xu A, Frei B, Curran-Celantano J, Shwaery GT etal: Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits Proc Natl Acad Sci USA 1993, 90: 11880–11884.
42. Keaney JF Jr., Guo Y, Cunningham D, Shwaery GT, Xu A, Vita JA: Vascular incorporation of α-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation J Clin Invest 1996, 98: 386–394.