Differential activation of the extracellular signal-regulated kinase, Jun Kinase and Janus Kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi's sarcoma cells

AIDS

Volumn 10, Issue 4, 1996, Pages 369-378

  Faris, Mary ^a   Ensoli, Barbara ^b   Stahl, Neil ^c   Yancopoulos, George ^c   Nguyen, Andrew ^a   Wang, Schwale ^a   Nel, Andre E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

ERK; JAK Stat; Kaposi's sarcoma

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; ONCOSTATIN M; PROTEIN KINASE; PROTEIN SERINE KINASE; PROTEIN SERINE THREONINE KINASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KAPOSI SARCOMA; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN PHOSPHORYLATION; SARCOMA CELL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; BASE SEQUENCE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTOR 2; GROWTH SUBSTANCES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; ONCOSTATIN M; PEPTIDES; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; SARCOMA, KAPOSI; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 0029967687     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199604000-00004     Document Type: Article

References (58)

1. Tappero JW, Conan M, Wolf SF, Berger TG: Kaposi's sarcoma: epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. J Am Acad Dermatol 1993, 28:371-395.
2. Barillari G, Buonaguro L, Fiorelli V, et al.: Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression. J Immunol 1992, 149:3727-3734.
3. Fiorelli V, Gengelman R, Samaniego F, Markham PD, Ensoli B: Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells. J Clin Invest 1995, 95:1723-1734.
4. Ensoli B, Markham P, Kao V, et al.: Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. J Clin Invest 1994, 94:1736-1746.
5. Samaniego F, Markham PD, Gallo RC, Ensoli B: Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice. J Immunol 1995, 154:3582-3592.
6. Ensoli B, Nakamura S, Salahuddin SZ, et al.: AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science 1989, 243:223-225.
7. Miles SA, Martinez-Maza O, Rezai A, et al.: Oncostatin M is a potent mitogen for AIDS-Kaposi's sarcoma (AIDS-KS). Science 1991, 255:1434-1436.
8. Nair BC, DeVico AL, Nakamura S, et al.: Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M. Science 1992, 255:1430-1432.
9. Cai J, Gill PS, Masood R, et al.: Oncostatin M is an autocrine growth factor in Kaposi's sarcoma. Am J Pathol 1994, 145:74-79.
10. Derijard B, Hibi M, Wu I-H, et al.: JNK-1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76:1025-1037.
11. Hibi M, Lin A, Smeal T, Minden A, Karin M: Identification of an oncoprotein- and UB-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993, 7:2135-2148.
12. Kalluki T, Su B, Ny I-T, et al.: JNK2 contains a specificity determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 1994, 8:2996-3007.
13. Sanchez I, Hughes RT, Moyer BJ, et al.: Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 1994, 372:794-798.
14. Lin A, Minden A, Martinetto H, et al.: Identification of a dual specificity kinase that activates the Jun kinases and p36-Mpk2. Science 1995, 268:286-290.
15. Yan M, Dal T, Deak JC, et al.: Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 1994, 372:798-800.
16. Kishimoto T, Taga T, Akira S: Cytokine signal transduction. Cell 1994, 76:253-262.
17. Muramaki M, Hibi M, Nakagawa N, Nakagawa T, Yamanashi K, Taga T, Kishimoto T: IL-6-induced homodimerization of gp130 and associated activation of tyrosine kinasae. Science 1993, 260:1808-1810.
18. Stahl N, Boulton TG, Farruggella T, et al.: Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor component. Science 1994, 263:92-95.
19. Lutticken L, Wegenka UM, Yuan J, et al.: Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 1994, 263:89-91.
20. Narazaki M, Witthuhn BA, Yoshida K, et al.: Activation of JAK2 kinase mediated by the interleukin-6 signal transducer gp130. Proc Natl Acad Sci USA 1994, 91:2285-2289.
21. Kumar G, Gupta S, Wang S, Nel AE: Involvement of Janus kinases, p52Shc, Raf-1, and MEK-1 in the IL-6 induced mitogen-activated protein kinase cascade of a growth responsive B cell line. J Immunol 1994, 153:4436-4447.
22. Wang T, Fuller GM: Phosphorylation and internalization of gp130 occur after IL-6 activation of JAK2 kinase in hepatocytes. Mol Biol Cell 1994, 5:819-828.
23. Feldman GM, Petricoin EF, Davis M, Larner AC, Finbloom DS: Cytokines that associate with the signal transducer gp130 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation. J Bio Chem 1994, 269:10747-10752.
24. Shuai K, Stark GR, Kerr IM, Darnell JE: A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 1993, 261:1744-1746.
25. Sadowski HB, Shuai K, Darnell JE, Gilman MZ: A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 1993, 261:1739-1744.
26. Boulton TG, Stahl N, Yancopoulos GD: Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin-6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 1994, 269:11648-11655.
27. Wegenka UM, Lutticken C, Buschman J, et al.: The interleukin-6-activated acute phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol Cell Biol 1994, 14:3186-3196.
28. Edgell CJ, McDonald CC, Graham JB: Permanent cell lines expressing factor VIII related antigen established by hybridization. Proc Natl Acad Sci USA 1983, 80:3743-3737.
29. Nakamura S, Salahuddin SZ, Biberfeld P, et al.: Kaposi's sarcoma cells: long term culture with growth factor from retrovirus infected CD4+ cells. Science 1988, 242:426-430.
30. Akira S, Nishio Y, Inove M, et al.: Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994, 77:63-71.
31. Yuan J, Wegenka UM, Lutticken C, et al.: The signaling pathway of interleukin-6 and gamma-interferon converge by the activation of different transcription factors which bind common responsive DNA elements. Mol Cell Biol 1994, 14:1657-1668.
32. Zhong Z, Wen Z, Darnell JE: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994, 264:95-98.
33. Fu X-Y, Zhang JJ: Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter. Cell 1993, 74:1135-1145.
34. MAPK/ERK2 in Kaposi's sarcoma cells. Evidence that this pathway is important in Kaposi cell growth. Clin Invest 1993, 92:848-857.
35. Gille H, Sharrocks A, Shaw P: Phosphorylation of p62TCF by MAP kinase stimulates ternary complex formation at c-Fos promoter. Nature 1992, 358:414-417.
36. Wu J, Rossomando AJ, Her JH, Vecchio RD, Weber MJ, Sturgill TW: Autophosphorylation in vitro of a recombinant 42-kilodalton mitogen activated protein kinase on tyrosine residues. Proc Natl Acad Sci USA 1991, 88:9508-9512.
37. Rossomando AJ, Sanghera JS, Marsden LA, Weber MJ, Pelech SL, Sturgill TW: Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylation. J Biol Chem 1991, 266:20270-20275.
38. Crews CM, Alessandrini A, Erikson RL: The primary structure of MEK, a protein kinase that phosphorylates ERK gene products. Science 1992, 258:478-481.
39. Kyriakis JM, Force TL, Rapp VR, Bonventre JV, Avruch J: Mitogen regulation of Raf-1 protein kinase activity toward mitogen activated protein kinase kinase. J Biol Chem 1993, 268:16009-16019.
40. Minden A, Lin A, Smeal T, et al.: c-Jun N-terminal phosphorylation correlates with activation of JNK subgroup but not ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol 1994, 14:6683-6688.
41. Gupta S, Campell D, Derijard B, Davis RJ: Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 1995, 267:389-393.
42. Angel P, Karin M: The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991, 1072:129-157.
43. Thomas G: MAP kinase by any other name smells just as sweet. Cell 1992, 8:3-6.
44. Rozakis-Adcock M, McGlade J, Mbamalu G, et al.: Association of the Shc and Grb2/Sem 5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature 1992, 360:689-692.
45. Lowenstein EJ, Daly RJ, Batzer AG, et al.: The SH2 and SH3 domain-containing protein Grb2 links receptor tyrosine kinases to Ras signalling. Cell 1992, 70:431-442.
46. Li N, Batzer A, Daly R, et al.: Guanine-nucleotide-releasing factor hSos 1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling. Nature 1993, 363:85-88.
47. Vainikka S, Joukov V, Wennstrom S, Bergman M, Pelicci PG, Alitalo K: Signal transduction by fibroblast growth factor receptor-4. J Biol Chem 1994, 269:18320-18326.
48. Wang J-K, Guangxia G, Goldfarb M: Fibroblast growth factor receptors have different signaling and mitogenic potentials. Mol Cell Biol 1994, 14:181-188.
49. Darnell JE, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264:1415-1420.
50. Schindler C, Shuai K, Prezioso VR, Darnell JE: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 1992, 257:808-815.
51. Sadowski HB, Gilman MZ: Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature 1993, 362:79-83.
52. Spandidos DA, Kaloterakis A, Yiaginisis M, Varatsos A, Field JK: Ras, c-myc, c-erb2 oncoprotein expression in non-AIDS mediterranean Kaposi's sarcoma. Anticancer Res 1990, 68:1031-1040.
53. Miyasaka T, Chao M, Sherline P, Saltiel A: Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2. J Biol Chem 1990, 265:4730-4735.
54. Welham MJ, Duronio V, Sanghera JS, Pelech SL, Schrader JW: Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members. J Immunol 1992, 149:1683-1693.
55. Minden A, Lin A, McMahon M, Lange-Carter C, Derijard B, Davis RJ, Johnson GL, Karin M: Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 1994, 266:1719-1723.
56. Jaye M, Schlessinger J, Dionne CA: Fibroblast growth factor receptor tyrosine kinase: molecular analysis and signal transduction. Biochim Biophys Acta 1992, 1135:185-189.
57. Mason IJ: The ins and outs of fibroblast growth factors. Cell 1994, 78:547-552.
58. Bellot F, Crumley G, Kaplow JM, Schlessinger J, Jaye M, Dionne CA: Ligand-induced transphosphorylation between different FGF receptors. EMBO J 1991, 10:2849-2854.