Inhibiting activity of some glucoindolalkaloids and iridoids from Sickingia williamsii on electrically induced contractions of isolated guinea-pig ileum

Phytotherapy Research

Volumn 10, Issue 2, 1996, Pages 161-166

  Aquino, R ^a   Capasso, A ^b   De Simone, F ^b   Garofalo, T L ^a   Pizza, C ^a   Sorrentino, L ^b  

^a Dipartimento di Chimica delle Sostanze Naturali   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Electrical contractions; Glucoindoalkaloids; Guinea pig ileum; Iridoids; Rubiaceae; Sickingia williamsii

Indexed keywords

3,4 DICAFFEOYLQUINIC ACID; 5ALPHA CARBOXYSTRICTOSIDINE; ALKALOID; CHLOROFORM; GLUCOINDOLE ALKALOID; HARMINE; IRIDOID; LOGANIC ACID; LOGANIN; LYALOSIDIC ACID; OLEANOLIC ACID; OPHIORINE A; OPHIORINE B; PETROLEUM ETHER; PLANT EXTRACT; SCOPOLETIN; SECOXYLOGANIN; SICKINGIA WILLIAMSII EXTRACT; SICKINGINE; SWEROSIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG PURIFICATION; ELECTROSTIMULATION; GUINEA PIG; ILEUM; MALE; NONHUMAN; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION;

EID: 0029967444     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199603)10:2<161::AID-PTR803>3.0.CO;2-B     Document Type: Article

References (15)

1. Aimi, N., Tsuyuki, T., Murakami, H., Sakai, S., and Haginiwa, J. (1985). Structure of ophiorines A and B: novel type glucoindole alkaloids isolated from Ophiorrhiza SPP. Tetr. Lett. 26, 5299-5302.
2. Aquino, R., De Simone, F., Senatore, R, and Pizza, C. (1988). Iridoids and secoiridoids from Guettarda Platypoda. Pharm. Res. Commun. 20 (5), 105-108.
3. Aquino, R., Garofalo, L, De Tommasi, N., Lock de Ugaz, O., and Pizza, C. (1994). Glucoindole alkaloids from bark of two Sickingia species. Phytochemistry 37, 1471-1476.
4. Boros, C. A., and Stermitz, F. R. (1990). Iridoid. An updated review. Part I. J. Nat. Prod. 53, 1055-1147.
5. Ferguson, G. G. (1972). Action of alkaloidal extract of Banisteriopsis quitensis on rabbit ileum. J. Pharm. Sci. 61, 623-624.
6. Ferrari. F., Messana, I. Botta, B., and De Mello, J. F. (1986). Constituents of Guettarda platypoda. J. Nat. Prod. 49, 1150-1151.
7. Hashimoto, Y., and Kawanisha, K. (1975). New organic bases from Amazonicum Banisteriopsis caapi. Phytochemistry 14, 1633-1636.
8. Hashimoto, Y, and Kawanisha, K. (1976). New alkaloids from Banisteriopsis caapi. Phytochemistry 15, 1553-1560.
9. Hidaka, K., Ito, M., Matsuda, Y, Kodha, H., Yamasaki, K., and Yamahara, J. (1987). A triterpene and saponin from roots of Ilex pubescens. Phytochemistry26, 2023-2027.
10. Kutchan, T. M. (1993). Strictosidine: from alkaloid to enzyme to gene. Phytochemistry 32, 493-506.
11. Mahmood, N., Moore, P. S., De Tommasi, N. et al. (1993). Inhibition of HIV Infection by caffeoyl quinic acid derivatives. Antiviral Chem. Chemother. 4, 235-240.
12. Okpako, D. T., and Taiwo, Y. O. O. (1984). Cyclo-oxygenase inhibitors antagonize indirectly evoked contractions of the guinea-pig isolated ileum by inhibiting acetylcholine release. Br. J. Pharmac. 82, 577-585.
13. Soukup, J. (1987). Vocabulario de los Nombres Vulgares de la Flora Peruana, p. 277. Editorial Salesiana, Lima.
14. Stull, R. E., Ferguson, N. M., and Ferguson, G. G. (1971). Selected pharmacological studies of an alkaloidal extract of Banisteriopsis quitensis. J. Pharm. Sci. 60, 1221-1223.
15. Tallarida, R. J., and Murray, R. B, (1987). Manual of Pharmacologic Calculation with Computer Programs, 2nd edn. Springer-Verlag, Berlin.