Distribution of Gs-α activating mutations in human thyroid tumors measured by subcloning

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 8, 1996, Pages 453-457

  Gorelov, Victor N ^a,b   Gyenes, Marianna ^a   Neser, Frank ^a   Röher, Hans Dieter ^a   Goretzki, Peter E ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Gs gene; mutations; sequencing; subcloning; thyroid tumors

Indexed keywords

ADULT; AGED; ARTICLE; DNA SEQUENCE; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; THYROID ADENOMA; THYROID FOLLICULAR CARCINOMA; THYROID TUMOR;

ADULT; AGED; BASE SEQUENCE; CLONING, MOLECULAR; CODON; DNA; ESCHERICHIA COLI; FEMALE; GTP-BINDING PROTEINS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; THYROID NEOPLASMS;

EID: 0029967320     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01187156     Document Type: Article

References (16)

1. Bos JL (1989) ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689
2. Gorelov VN, Röher H-D, Goretzki PE (1994) A method to increase the sensitivity of mutation specific oligonucleotide hybridization using asymmetric polymerase chain reaction (PCR). Biochem Biophys Res Commun 200:365-369
3. Gorelov VN, Dumon K, Barteneva NS, Palm D, Röher H-D, Goretzki PE (1995) Overexpression of Gs-α subunit in thyroid tumors bearing a mutated Gs-α gene. J Cancer Res Clin Oncol 121:219-224
4. Goretzki PE, Lyons J, Stacy-Phipps S, Rosenau W, Demeure M, Clark OH, McCormic Röher H-D, Bourne HR (1992) Mutational activity of RAS and GSP oncogenes in differentiated thyroid cancer and their applications. World J Surg 16:576-581
5. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L (1989) GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumors. Nature 340:692-696
6. Landis CA, Harsh G, Lyons J, Davis RL, McCormic F, Bourne HR (1990) Clinical characteristics of acromegalic patients whose pituatry tumors contain mutant Gs protein. J Endocrinol Metab 71:1416-1420
7. Levi S, Urbano-Ispizua A, Gill R, Thomas DM, Gilbertson J, Foster C, Marshall CJ (1991) Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 51:3497-3502
8. Lyons J, Landis CA, Harsh G, Vallar L, Grünewald K, Feichtinger H, Duh Q-Y, Clark OH, Kawasaki E, Bourne HR, McCormic F (1990) Two G protein oncogenes in human endocrine tumors. Science 249:665-659
9. Matsuo K, Friedman E, Gejman PV, Fagin JA (1993) The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the α-subunit of Gs in human thyroid neoplasms. J Clin Endocrinol Metab 76:1448-1451
10. Miller RT, Masters SB, Sullivan KA, Biederman B, Bourne HR (1988) A mutation that prevents GTP-dependent activation of the α chain of Gs. Nature 334:712-715
11. Müller A, Gorelov V, Möllner S, Röher H-D, Goretzki PE (1994) Importance of adenylate cyclase and G-protein mutations in prognosis of differentiated thyroid tumors (in German) In: Trede M, Siewert JR, Hartel W (eds) Chirurgishes Forum 1994 für experimentelle und klinische Forschung. Springer, Berlin Heidelberg New York, pp 349-353
12. Sanger F, Nickeln S, Coulson AR (1977) DNA sequencing with chainterminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
13. Schwindinger WF, Francomano CA, Levin MA (1992) Identification of a mutation in the gene encoding the α subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albricht syndrome. Proc Natl Acad Sci USA 89:5152-5156
14. Siperstein AE, Miller RA, Landis C, Bourne H, Clark OH (1991) Increased stimulatory G protein in neoplastic human thyroid tissues. Surgery 110:949-955
15. Spada A, Arosio M, Bochiccio D, Bazzoni N, Vallar L, Bassetti M, Faglia G (1990) Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab 71: 1421-1426
16. Suarez HG, du Villard JA, Caillou B, Schlumberger M, Permentier C, Monier R (1991) GSP mutations in human thyroid tumors. Oncogene 6:677-679