Quinacrine noncompetitive inhibitor binding site localized on the torpedo acetylcholine receptor in the open state

Biochemistry

Volumn 35, Issue 20, 1996, Pages 6330-6336

  Johnson, David A ^a   Ayres, Scott ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; MEPACRINE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC ORGAN; INHIBITION KINETICS; LIPID BILAYER; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; TORPEDO CALIFORNICA;

ANIMALS; BINDING SITES; CARBACHOL; CYCLIC N-OXIDES; DANSYL COMPOUNDS; ELECTRIC ORGAN; FLUORESCENT DYES; KINETICS; LIPID BILAYERS; NICOTINIC ANTAGONISTS; PROTEIN CONFORMATION; QUATERNARY AMMONIUM COMPOUNDS; QUINACRINE; RECEPTORS, NICOTINIC; SPIN LABELS; TORPEDO;

EID: 0029967067     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960123p     Document Type: Article

References (35)

1. Adams, P. R. (1981) J. Membr. Biol. 58, 161-174.
2. Adams, P. R., & Feltz, A. (1980) J. Physiol. 306, 261-281.
3. Akabas, M. H., & Karlin, A. (1995) Biochemistry 34, 12496-12500.
4. Akabas, H. M., Kaufmann, C., Archdeacon, P., & Karlin, A. (1994) Neuron 13, 919-927.
5. Andreasen, T. J., & McNamee, M. G. (1980) Biochemistry 19, 4719-4726.
6. Arias, H. R., Valenzuela, C. F., & Johnson, D. A. (1993a) J. Biol. Chem. 268, 6348-6355.
7. Arias, H. R., Valenzuela, C. F., & Johnson, D. A. (1993b) Biochemistry 32, 6237-6242.
8. Blanton, M. P., & Cohen, J. B. (1992) Biochemistry 31, 3738-3750.
9. Blanton, M. P., & Cohen, J. B. (1994) Biochemistry 33, 2859-2872.
10. Boyd, N. D., & Cohen, J. B. (1984) Biochemistry 23, 4023-4033.
11. Changeux, J.-P., Galzi, J.-L., Devillers-Thiery, A., & Bertrand, D. (1992) Q. Rev. Biophys. 25, 395-435.
12. Chattopadhyay, A., & McNamee, M. G. (1991) Biochemistry 30, 7159-7164.
13. Claudio, T., Ballivet, M., Patrick, P., & Heinemann, S. (1983) Nature 80, 1111-1115.
14. Forman, S. A., Firestone, L. L., & Miller, K. W. (1987) Biochemistry 26, 2807-2814.
15. Green, J. A., & Singer, L. A. (1973) J. Chem. Physics 58, 2690-2695.
16. Green, S. A., Simson, D. J., Zhou, G., & Blough, N. V. (1990) J. Am. Chem. Soc. 112, 7337-7346.
17. Grünhagen, H.-H., & Changeux, J.-P. (1976) J. Mol. Biol. 106, 517-535.
18. Grünhagen, H.-H., Iwatsubo, M., & Changeux, J.-P. (1977) Eur. J. Biochem. 80, 225-242.
19. Heidmann, T., & Changeux, J.-P. (1979a) Eur. J. Biochem. 94, 255-279.
20. Heidmann, T., & Changeux, J.-P. (1979b) Eur. J. Biochem. 94, 281-296.
21. Heidmann, T., Qswald, R. E., & Changeux, J.-P. (1983) Biochemistry 22, 3112-3127.
22. Johnson, D. A., & Yguerabide, J. (1985) Biophys. J. 48, 949-955.
23. Jones, O. T., & McNamee, M. G. (1988) Biochemistry 27, 2364-2374.
24. Karlin, A. (1991) Harvey Lect. 85, 71-107.
25. Karlin, A. (1993) Curr. Opin. Neurobiol. 3, 299-309.
26. McCarthy, M. P., & Moore, M. A. (1992) J. Biol. Chem. 267, 7655-7633.
27. Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Furutani, Y., Hirose, T., Asai, M., Inayama, S., Miyata, T., & Numa, S. (1982) Nature 299, 793-797.
28. Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Kikyotani, S., Hirose, T. Asai, M., Takashima, H., Inayama, S., Miyata, T., & Numa, S. (1983) Nature 301, 251-255.
29. Raftery, M. A., Hunkapiller, M. W., Stader, C. D., & Hood, L. E. (1980) Science 208, 1454-1457.
30. Reynolds, J. A., & Karlin, A. (1978) Biochemistry 17, 2035-2038.
31. Unwin, N., Toyoshima, C., & Kubalek, E. (1988) J. Cell Biol. 106, 1123-1138.
32. Valenzuela, C. F., Kerr, J. A., & Johnson, D. A. (1992) J. Biol. Chem. 267, 8238-8244.
33. Valenzuela, C. F., Weign, P., Yguerabide, J., & Johnson, D. A. (1994a) Biophys. J. 66, 674-682.
34. Valenzuela, C. F., Dowding, A. J., Arias, H. R., & Johnson, D. A. (1994b) Biochemistry 33, 6586-6594.
35. Weiland, G., Georgia, B., Lappi, S., Chignell, C. F., Taylor, P. (1977) J. Biol. Chem. 252, 7648-7656.