Neoplastic and non-neoplastic lesions in the mammary gland, endocrine and genital organs in aging male and female Sprague-Dawley rats

Archives of Toxicology

Volumn 70, Issue 8, 1996, Pages 461-473

  Attia, M A ^a  

^a Centre International de Toxicologie (CIT)   (France)

Author keywords

Aging rats; Endocrine organs; Gonads; Mammary gland; Neoplasia; Sprague Dawley

Indexed keywords

ADRENAL GLAND; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOCRINE GLAND; FEMALE; GENITAL SYSTEM; HYPOPHYSIS; HYPOPHYSIS ADENOMA; MALE; MAMMARY GLAND; NEOPLASM; NONHUMAN; OVARY; PRIORITY JOURNAL; RAT; SENILITY; TESTIS; THYROID GLAND; TISSUE INJURY; UTERUS;

AGE FACTORS; ANIMALS; ENDOCRINE GLAND NEOPLASMS; ENDOCRINE GLANDS; ENDOCRINE SYSTEM DISEASES; FEMALE; MALE; RATS; RATS, SPRAGUE-DAWLEY; RODENT DISEASES;

EID: 0029967055     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050300     Document Type: Article

References (77)

1. Attia MA (1978) A modified tetrachrome staining technique for the adenohypophysis of dog, rats and rabbits. Arch Toxicol 40: 295-301
2. Attia MA (1980) Cytological study on pituitary adenomas in senile untreated bitches. Arch Toxicol 46: 287-293
3. Attia MA (1982) Cytological study on the anterior pituitary of senile untreated Beagle bitches with spontaneous mammary tumours. Arch Toxicol 50: 35-45
4. Attia MA (1985) Neoplastic and non-neoplastic lesions in aging female rats with special reference to the functional morphology of the hyperplastic and neoplastic changes in the pituitary gland. Arch Toxicol 57: 77-83
5. Berkvens JM, van Nesselrooy JHJ, Kroes R (1980) Spontaneous tumours in the pituitary gland of old Wister rats. A morphological and immunocytological study. J Pathol 130: 179-191
6. Birkenhager JC, Upon GV, Seldenrath HJ, Krieger DT, Tashjian AH Jr (1967) Medullary thyroid carinoma: ectopic production of peptides with ACTH-like, corticotrophin releasing factor-like and prolactin production-stimulating acivity. Acta Endocrinol (Kbh) 83: 280
7. Biswas R, Vonderhaar BK (1991) Tamoxifin inhibition of prolactin action in the mouse mammary gland. Endocrinology 128: 532-538
8. Blake MJ, Buckley DJ, Buckley AR (1993) Dopaminergic regulation of heat shock protein-70 expression in adrenal gland and aorta. Endocrinology 132: 1063-1070
9. Burek JD (1978) Pathology of aging rats. CPC Press, West Palm Beach, Fla., pp 54-58
10. Calvo JC, Finocchiaro L, Luthy I, Charreau EH, Calandra RS, Engstrom B, Hansson V (1981) Specific prolactin binding in the rat adrenal gland: its characterization and hormonal regulation. J Endocrinol 89: 317-325
11. Carlton WW, Gries CL (1983) Adenoma and carcinoma in pars distalis and pars intermedia. In: Jones TC, Mohr U, Hung RD (eds) Endocine system monographs on pathology of laboratory animals. Springer-Verlag, Berlin, pp 134-149
12. Chandra M, Riley MGI, Johnson DE (1992) Spontaneous neoplasms in aged Sprague-Dawley rats. Arch Toxicol 66: 496-502
13. Clevenger CV, Wan-Pin Chung, Ngo W, Pasha TLM, Montone KT, Tomaszewski JE (1995) Expression of prolactin and prolactin receptor in human breast carcinoma. Am J Pathol 146: 695-705
14. Crain RC (1958) Spontaneous tumours in the Rochester strain of the Wister rat. Am J Pathol 34: 311-335
15. DeLellis RA, Wolf HJ, Gagel RF, Feldman ZT, Miller HH, Gang DL, Reichlin S (1976) Adrenal medullary hyperplasia: a morphometric analysis in patients with familial medullary thyroid carcinoma. Am J Pathol 83: 177
16. Doniach I, Williams ED (1962) The development of thyroid and pituitary tumours in the rats two years after partial thyrodidectomy. Br J Cancer 16: 222-231
17. Estes KS, Simpkins JW (1980) Age related alterations in catecholamine concentrations in discrete preoptic area and hypothalamic region in the male rat. Brain Res 194: 556-560
18. Estes KS, Simpkins JW (1982) Resumption of pulsatile luteinizing hormone release after alpha adrenergic stimulation in aging constant estrous rats. Endocrinology 111: 1778-1784
19. Estes KS, Simpkins JW (1984) Age related alteration in catecholamine activity within microdissected brain regions of ovariectomized Fischer 344 rats. J Neurosci Res 11: 405-417
20. Frantz AG (1978) Prolactin. N Engl J Med 298: 201-207
21. Furth J, Ueda G, Clifton KH (1973) The pathophysiology of pituitaries and their tumours: methodological advances. In: Busch (ed) Methods in cancer research, vol. 10. Academic Press, New York, pp 201-277
22. Furth J, Nakane P, Pasteels JL (1976) Tumours of the pituitary gland. In: Turusov VS (ed) Pathology of tumours in laboratory animals. IARC Sci Publ 6: 201-238
23. Gillman J, Gilbert C, Spence I (1953) Pheochromocytoma in the rats. Pathogenesis and chollateral reaction and its relation to comparable tumours in man. Cancer 6: 494-511
24. Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and non-eoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48: 237-248
25. Gregson RL, Lewis DJ, Abbot DP (1984) Spontaneous neoplasms of the laboratory rats. Vet Pathol 21: 292-299
26. Gross L, Dreyfuss Y (1979) Spontaneous tumours in Sprague-Dawley and Long-Evans rats in their F1 hybrids: carcinogenic effect of total body X-irradiation. Proc Natl Acad Sci 76: 5910-5913
27. Holtkamp W, Nagel GA (1989) Clinical aspects on the role of prolactin in human breast cancer. In: Nasagawa H (ed) Prolactin and lesions in breast, uterus and prostate. CRC Press, Boca Raton, pp 23-28
28. Ingram M, Nottage EM, Roberts AN (1990) Prolactin and breast cancer risk. Med J Aust 153: 469-473
29. Jacobs BB, Huseby RA (1967) Neoplasms occurring in aged Fischer rats, with special reference to testicular, uterine and thyroid tumours. J Natl Cancer Inst 39: 303-309
30. Koneff AA, Moon HD, Simpson ME, Li CH, Evans HM (1951) Neoplasms in rats treated with pituitary growth hormone. IV. Pituitary gland. Cancer Res 11: 113-117
31. Kovacs K, Horvath E, Ilse RG, Ezrin C, Ilse D (1977) Spontaneous pituitary adenomas in aging rats. A light microscopic, immunocytological and fine structural study. Beitr Pathol 161: 1-16
32. Kovacs K, Ryan N, Horvath E, Ezrin C, Penz G (1978) Prolactin cell adenomas of the human pituitary. Morphologic features of prolactin cells in the nontumerous portions of the anterior lobe. Horm Metab Res 10: 409-412
33. Kovacs K, Ilse G, Ryan N, McComb DJ, Horvath E, Chen HJ, Walfish PG (1980) Pituitary prolactin cell hyperplasia. Horm Res 12: 87-95
34. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L (1989) GTPase inhibiting mutations activate the a chain of Gs and stimulate adenyl cyclase in human pituitary tumours. Nature 340: 692-696
35. Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR (1990) Characteristics of acromegalic patients whose pituitary tumours contain mutant Gs protein. J Clin Endocrinol Metab 71: 1416-1420
36. Lee AK, DeLellis RA, Blount M, Nunnemacher G, Wolf HJ (1982) Pituitary proliferative lesions in aging male Long-Evans rats. A model of mixed multiple endocrine neoplasia syndrome. Lab Invest 47: 595-602
37. Lewis DJ (1987) Ovarian neoplasms in the Sprague-Dawley rats. Environ Health Perspect 73: 77-90
38. Lipman NS, Zhao Zhi-Bo, Andrutis KA, Hurley RJ, Fox JG, White HJ (1994) Prolactin-secreting pituitary adenomas with mammary dysplasia in New Zealand white rabbits. Lab Anim Sci 44: 114-120
39. Lu KH, Hopper BR, Vargo TM, Yen SSC (1979) Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different preproductive states. Biol Reprod 21: 193-203
40. Maekawa A, Onodera H, Tanigawa H, Furuta K, Matsuoka C, Kanno J, Ogiu T, Hayashi Y (1986) Spontaneous neoplastic and non-neoplastic lesions in aging Donryu rats. Jpn J Cancer Res 77: 882-890
41. Marij S, Fujii T (1973) Spontaneous tumours in Sprague-Dawley rats. Exp Anim 22: 127-138
42. McComb DJ, Kovacs K, Ben J, Zak F (1984) Pituitary adenomas in old Sprague-Dawley rats: A histologic, ultrastructural, and immunocytochemical study. JNCL 73: 1143-1166
43. McMartin DN, Sahota PS, Gunson DE, Hsu HH, Spaet RH (1992) Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic consideration. Toxicol Pathol 20: 212-225
44. Murdoch GH, Potter E, Nicholson AK, Evans RM, Rosenfield MG (1982) Epidermal growth factor rapidly stimulates prolactin gene transcription. Nature 300: 192
45. Nagasawa H, Welsch CW (1989) In: Nagasawa H (ed) Prolactin and lesions in breast, uterus and prostate, CRC Press, Boca Raton, pp 39-50
46. Nagasawa H, Mori T, Sakamoto S, Sassa S, Yamamuro Y, Sensui N, Tajima M, Goto Y (1994) Changes with age of mammary glands in male and female soft-furred rat, Millardia meltada, in relation to prolactin and testosterone. Lab Anim 28: 35-43
47. Nankin HR (1981) Leydig cell function in man. J SC Med Assoc 77: 531-535
48. Nishino Y, Michna H, Hasan SH, Schneider MR (1992) Involvement of the adrenal glands in the prolactin rise induced in the female rat by an antiprogestin, onapristone. J Steroid Biochem Mol Biol 41: 841-845
49. Pecile A, Bossa R (1976) Age changes in hypothalamic-pituitary function. In: Everitt and Burgess (eds) Hypothalamus pituitary and aging. Thomas, Springfield, pp 86-96
50. Pecile A, Muller E, Falconi G, Martini L (1965) Growth hormone-releasing activity of hypothalamic extracts at different ages. Endocrinology 77: 241-246
51. Pelc SR (1968) Turnover of DNA and function. Nature 219: 162-163
52. Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumours in Sprague-Dawley rats and Swiss mice. Cancer Res 33: 2768-2773
53. Reddy BS, Cohen LA, McCoy GD, Hill P, Weisburger JH, Wynder EL (1980) Nutrition and its relationship to cancer. Adv Cancer Res 32: 237-345
54. Riegle GD, Meites J (1976) Effect of aging on LH and prolactin after LHRH, L-dopa and stress in male rat. Proc Soc Exp Med 151: 507-511
55. Riegle GD, Meites J, Muller AE, Woods SM (1977) Effects of aging on hypothalamic LH-releasing and prolactin-inhibiting activities and pituitary responsiveness to LHRH in the male laboratory rat. J Gerontol 32: 13-18
56. Rose DP, Noonan JJ (1982) Influence of prolactin and growth hormone on rat mammary tumours induced by N-nitrosomethylurea. Cancer Res 42: 35-38
57. Sacksteder MR (1976) Occurrence of spontaneous tumours in the perm-free F344 rat. J Natl Cancer Inst 57: 1371-1373
58. Sandusky GE, Van Pelt CS, Todd GC, Wightman K (1988) An immunocytochemical study of pituitary adenomas and focal hyperplasia in old Sprague-Dawley and Fischer 344 rats. Toxicol Pathol 16: 376-380
59. Sarkar DK, Gottschall PE, Meites J (1982) Damage to hypothalamic dopaminergic neurons is associated with the development of prolactin-secreting pituitary tumours. Science 218: 684-686
60. Sass B, Rabestein LS, Madison R, Nims RM, Peters RL, Kelloff GJ (1975) Incidence of spontaneous neoplasms in F344 rats throughout the natural life-span. J Natl Cancer Inst 54: 1449-1456
61. Saxton JA, Graham JB (1944) Chromophobe adenoma-like lesions of the rat hypophysis. Frequency of the spontaneous lesions and characteristics of growth of homologous intraocular transplants. Cancer Res 4: 168-175
62. Schonbrunn A, Krasnoff M, Westendorg JM, Tashjian AH (1980) Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhibition of cell proliferation. J Cell Biol 85: 786-797
63. Shiu RPC, Murphy LC, Tsuyuki D, Myal Y, Lee-Wing M, Iwasiow B (1987) Biological actions of prolactin in human breast carcinoma. Recent Prog Horm Res 43: 277-299
64. Simpson AA, Schmid GH (1971) Effect of prolactin on nucleic acid metabolism during lactogenesis in rabbits. J Endocrinol 51: 265-270
65. Simpkins JW, Mueller GP, Huang HH, Meites J (1977) Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: possible relation to gonadotropin secretion. Endocrinology 100: 1672-1678
66. Suzuki H, Mohr U, Kimmerle G (1979) Spontaneous endocrine tumors in Sprague-Dawley rats. J Cancer Res Clin Oncol 95: 187-196
67. Tiong TS, Stevenson JL, Herington AC (1992) Regulation of prolactin receptor gene expression by thyroid hormone status in the rat. J Mol Endocrinol 8: 63-72
68. Trovilias J, Girod C, Claustrat B, Cure M, Dubois MP (1982) Spontaneous pituitary tumours in the Wister/Furth/ico rat strain. Am J Pathol 109: 57-70
69. Turkington RW, Mayumder GC, Kadohama N, Maclndoe JH, Frantz WL (1973) Hormonal regulation of gene expression in mammary cells. Rec Prog Horm Res 29: 417-445
70. Turusov VS (1973) Pathology of tumours in laboratory animals, vol. I: tumours of the rat. part 1. IARC, Lyon, France
71. Turusov VS, Mohr U (1990) Pathology of tumours of laboratory animals. Tumours of the rat. IARC, Lyon, France
72. Umezu M, Fujimura T, Sugawara S, Kagabu S (1993) Pituitary and serum levels of prolactin (PRL), thyroid stimulatin hormones (TSH) and serum thyroxine (T4) in hereditary dwarf rats (rdw/ rdw). Exp Anim 42: 211-216
73. Vallar L, Spada A, Giannattasio G (1987) Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330: 566-568
74. Vermeullen A (1976) Leydig cell function in old age. In: Everit AV, Burgess JA (eds) Hypothalamus, pituitary and aging. Thomas, Springfield, III, pp 458-463
75. Webster J, Ham J, Bevan JS, Scanlon MF (1989) Growth factors and pituitary tumours. Trends Endocrinol Metab; November/December: 95-98
76. Welsch CW, Nagaswa H (1977) Prolactin and murine models for human breast cancer: A review. Cancer Res 37: 951-963
77. Wolfe JM, Bryan WR, Wright AW (1938) Histologic observations on the anterior pituitaries of old rats with particular reference to the spontaneous appearance of pituitary adenomata. Am J Cancer 34: 352-372