The effect of pH on the in-vitro dissolution of three second-generation sulphonylurea preparations: Mechanism of antacid-sulphonylurea interaction

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 9, 1996, Pages 899-901

  Lehto, Pasi ^a   Laine, Kari ^a   Kivistö, Kari T ^b   Neuvonen, Pertti J ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTACID AGENT; BICARBONATE; GILEMID; GLIBENCLAMIDE; GLIPIZIDE; MAGNESIUM HYDROXIDE; MELIZID; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; PH; STOMACH PH;

EID: 0029966925     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb05997.x     Document Type: Article

References (9)

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2. Kivistö, K. T., Neuvonen, P. J. (1991b) Differential effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide. Eur. J. Clin. Pharmacol. 40: 383-386
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6. Neuvonen, P. J., Kivistö, K. (1991) The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations. Br. J. Clin. Pharmacol. 32: 215-220
7. Neuvonen, P. J., Kivistö, K. (1994) Enhancement of absorption by antacids-an unrecognized drug interaction. Clin. Pharmacokinet. 27: 120-128
8. Rupp, W., Christ, O., Fülberth, W. (1972) Untersuchungen zur Bioavailability von Glibenclamid. Arzn. Forsch. 22: 471-473
9. Tuderman, V., Klinge, E., Lind, H. (1979) In vitro evaluations of antacid suspensions marketed in Finland. Acta Pharm. Fenn. 88: 63-72