Comparison of in vitro and in vivo inhibitory effects of peptide and nonpeptide oxytocin antagonists on radioligand binding and uterine contractility of rats during pregnancy

American Journal of Obstetrics and Gynecology

Volumn 175, Issue 5, 1996, Pages 1348-1355

  Kawarabayashi, T ^a   Kobayashi, M ^a   Akahane, M ^a   Ajisawa, Y ^a  

^a FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

oxytocin antagonist; Oxytocin binding; pregnancy; uterine contraction

Indexed keywords

OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; PROSTAGLANDIN F2 ALPHA; RADIOLIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; FEMALE; INHIBITION KINETICS; LIGAND BINDING; MYOMETRIUM; NONHUMAN; PATHOPHYSIOLOGY; PREMATURE LABOR; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING; UTERUS CONTRACTILITY;

EID: 0029966759     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(96)70053-4     Document Type: Article

References (14)

1. SN Caritis JP Chiao JJ Moore SM. Ward Myometrial desensitization after ritodrine infusion Am J Physiol 253 1987 E410 E417
2. T Kawarabayashi T Tsukamoto Y Kaneko M Ikeda H Sugimori K. Shirakawa Changes in beta-adrenergic receptors under long-term application of ritodrine in pregnant-rat myometrium Gynecol Obstet Invest 35 1993 136 139
3. MS. Soloff Endocrine control of parturition 2nd ed RM Wynn WP Jollie Biology of the uterus. 1989 Plenum Press New York 559 607
4. 8] vasotocin, an oxytocin antagonist, in animal models of uterine contractility and preterm labor: a new tocolytic agent. Am J Obstet Gynecol 157 1987 977 982
5. KT Demarest DW Hahn E Ericson RJ Capetola A-R Fuchs JL. McGuire Profile of an oxytocin antagonist, RWJ 22164 for treatment of preterm labor in laboratory models of uterine contractility Am J Perinatol 6 1989 200 204
6. DJ Pettibone BV Clineschmidt MT Kishel EV Lis DR Reiss CJ Woyden Identification of an orally active, nonpeptidyl oxytocin antagonist J Pharmacol Exp Ther 264 1993 308 314
7. S Lundin M Kerlund MP-O Fagerstr A Hauksson P Melin Pharmacokinetics in the human of a new synthetic vasopressin and oxytocin uterine antagonist Acta Endocrinol 112 1986 465 472
8. M Åkerlund A Hausson S Lundin P Melin J. Trojnar Vasotocin analogues which competitively inhibit vasopressin stimulated uterine activity in healthy women Br J Obstet Gynaecol 93 1986 22 27
9. DJ Pettibone BV Clineschmidt PS Anderson RM Freidinger GF Lundell LR Koupal A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis Endocrinology 125 1989 217 222
10. DJ Pettibone BV Clineschmidt MG Bock BE Evans RM Freidinger DF Veber Development and pharmacological assessment of novel peptide and nonpeptide oxytocin antagonists Regul Peptides 45 1993 289 293
11. TM Goodwin R Paul H Silver W Spellacy M Parsons R Chez The effect of the oxytocin antagonist atosiban on preterm uterine activity in the humans Am J Obstet Gynecol 170 1994 474 478
12. T Yoshida H Suzuki Y Hattori K. Noda Hormonal changes around the parturition in rats Tohoku J Exp Med 135 1981 87 91
13. T Higuchi Y Tadokoro K Honda H. Negoro Detailed analysis of blood oxytocin levels during suckling and parturition in the rat J Endocrinol 110 1986 251 256
14. Y Kaneko T Kawarabayashi H Sugimori T. Tsukamoto Changes in kinetic properties of oxytocin receptors in longitudinal muscle membranes of rat uterus during gestation J Mol Recog 8 1995 179 183