Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells

European Journal of Pharmacology

Volumn 298, Issue 3, 1996, Pages 279-286

  Garcia Barrado, Maria José ^a   Jonas, Jean Christophe ^a   Gilon, Patrick ^a   Henquin, Jean Claude ^a  

^a UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

Ca2+, cytoplasmic; Glibenclamide; Insulin release; Islet, mouse; K+ channel, ATP sensitive; Pancreatic B cell; Stimulus secretion coupling; Sulphonylurea; Tolbutamide

Indexed keywords

ACETYLCHOLINE; ANTIDIABETIC AGENT; ARGININE; BARIUM; CALCIUM; FORSKOLIN; GLIBENCLAMIDE; GLUCOSE; INSULIN; MEGLITINIDE; PHENTOLAMINE; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM ION; QUININE; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; FEMALE; INSULIN RELEASE; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CYTOPLASM; CYTOSOL; FEMALE; GLYBURIDE; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; MICE; PHOSPHOLIPASE C; POTASSIUM; SULFONYLUREA COMPOUNDS; TOLBUTAMIDE;

EID: 0029966475     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00806-3     Document Type: Article

References (37)

1. 2+ in mouse pancreatic β-cells following stimulation by hypoglycemic sulfonylureas, FEBS Lett. 190, 21.
2. Aguilar-Bryan, L., C.G. Nichols, S.W. Wechsler, J.P. Clement, A.E. Boyd, G. Gonzalez, H. Herrera-Sosa, K. Nguy, J. Bryan and D.A. Nelson, 1995, Cloning of the β-cell high-affinity sulfonylurea receptor: a regulator of insulin secretion, Science 268, 423.
3. Ali, L., E. Grapengiesser, E. Gylfe, B. Hellman and P.-E. Lund, 1989, Free and bound sodium in pancreatic β-cells exposed to glucose and tolbutamide, Biochem. Biophys. Res. Commun. 164, 212.
4. Ämmälä, C., K. Bokvist, L. Eliasson, E. Rehnström and P. Rorsman, 1994, Sulphonylurea and exocytosis in mouse β-cells: a possible interaction with protein kinase C, Diabetologia 37 (Suppl. 1), A48 (abstract).
5. Ashcroft, S.J.H. and F.M. Ashcroft, 1992, The sulfonylurea receptor, Biochim. Biophys. Acta 1175, 45.
6. ATP channel, Nature 370, 456.
7. + channels in mouse pancreatic β-cells by external tetraethylammonium and quinine, J. Physiol. 423, 327.
8. Brown, C.A., S.L.F. Chan, M.R. Stillings, S.A. Smith and N.G. Morgan, 1993, Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080, Br. J. Pharmacol. 110, 1017.
9. Dunne, M.J. and O.H. Petersen, 1991, Potassium selective ion channels in insulin-secreting cells: physiology, pharmacology and their role in stimulus-secretion coupling, Biochim. Biophys. Acta 1071, 67.
10. Flatt, P.R., O. Shibier, J. Szecowka and P.O. Berggren, 1994, New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell, Diabete Metab. 20, 157.
11. Föhr, K.J., W. Warchol and M. Gratzl, 1993, Calculation and control of free divalent cations in solutions used for membrane fusion studies, Methods Enzymol. 221, 149.
12. + channels in mouse B-cells, J. Clin. Invest. 91, 871.
13. 2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell, J. Biol. Chem. 267, 20713.
14. Gylfe, E., B. Hellman, J. Sehlin and I.B. Täljedal, 1984, Interaction of sulfonylurea with the pancreatic B-cell, Experientia 40, 1126.
15. + channels may control glucose-induced electrical activity in pancreatic B-cells, Biochem. Biophys. Res. Commun. 156, 769.
16. Henquin, J.C., 1992, The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?, Diabetologia 35, 907.
17. Henquin, J.C., 1994, The cell biology of insulin secretion, in: The Joslin's Diabetes Mellitus, 13th edn., eds. G.C. Weir and C.R. Kahn (Lea and Febiger, Philadelphia) p. 56.
18. 86Rb fluxes in pancreatic β-cells, Am. J. Physiol. 240, E245.
19. + fluxes and membrane potential in pancreatic B-cells, Biochem. Pharmacol. 31, 1407.
20. + channels in pancreatic β-cells, Br. J. Pharmacol. 107, 8.
21. 2+ and guanosine 5′-[γ-thio]triphosphate action on insulin secretion from α-toxin-permeabilized HIT-T15 cells, Biochem. J. 301, 523.
22. 2-adrenoceptor antagonist, Eur. J. Pharmacol. 254, 27.
23. ATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11, Proc. R. Soc. London 253, 225.
24. Misler, S., D.W. Bamett, K.D. Gillis and D.M. Pressel, 1992, Electrophysiology of stimulus-secretion coupling in human β-cells, Diabetes 41, 1221.
25. Nelson, D.A., L. Aguilar-Bryan, H. Raef and A.E. Boyd, 1992, Molecular mechanisms of sulphonylurea action in the pancreatic B-cell, in: Nutrient Regulation of Insulin Secretion, ed. P.R. Flatt (Portland Press, London and Chapel Hill) p. 319.
26. Ozanne, S.E., P.C. Guest, J.C. Hutton and C.N. Hales, 1995, Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells, Diabetologia 38, 277.
27. Palmer, M., R. Jursch, U. Weller, A. Valeva, K. Hilgert, M. Kehoe and S. Bhakdi, 1993, Staphylococcus aureus α-toxin, production of functionnally intact, site-specifically modifiable protein by introduction of cystein at positions 69, 130 and 186, J. Biol. Chem. 268, 11959.
28. Panten, U., B.J. Zünkler, S. Scheit, K. Kirchhoff and S. Lenzen, 1986, Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide, Diabetologia 29, 648.
29. Panten, U., M. Schwanstecher, A. Wallasch and S. Lenzen, 1988, Gucose both inhibits and stimulates insulin secretion from isolated pancreatic islets exposed to maximally effective concentrations of sulfonylureas, Naunyn-Schmied. Arch. Pharmacol. 338, 459.
30. Panten, U., J. Burgfeld, F. Goerke, M. Rennicke, M. Schwanstecher, A. Wallasch, B.J. Zünkler and S. Lenzen, 1989, Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets, Biochem. Pharmacol. 38, 1217.
31. + channels in mouse pancreatic B-cells, Br. J. Pharmacol. 101, 115.
32. Ribalet, B. and P.M. Beigelman, 1981, Effects of divalent cations on β-cell electrical activity, Am. J. Physiol. 241, C59.
33. Schwanstecher, M., C. Brandt, S. Behrends, U. Schaupp and U. Panten, 1992, Effect of MgATP on pinacidil-induced displacement of glibenclamide from the sulphonylurea receptor in a pancreatic α-cell line and rat cerebral cortex, Br. J. Pharmacol. 106, 295.
34. Sturgess, N.C., M.L.J. Ashford, D.L. Cook and C.N. Hales, 1985, The sulphonylurea receptor may be an ATP-sensitive potassium channel, Lancet 2, 474.
35. + channels in mouse pancreatic beta-cells, Pflüg. Arch. 47, 493.
36. 3H]glibenclamide in rat tissues, Jpn. J. Pharmacol. 67, 35.
37. + currents in pancreatic B-cells, Naunyn-Schmied. Arch. Pharmacol. 337, 225.