Effects of ursodiol or ibuprofen on contraction of gallbladder and bile among obese patients during weight loss

Digestive Diseases and Sciences

Volumn 41, Issue 2, 1996, Pages 242-249

  Marks, Jay W ^b   Bonorris, George G ^b   Schoenfield, Leslie J ^b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b NONE

Author keywords

Bile; Gallbladder; Gallstones; Ibuprofen; Obesity; Ursodiol; Weight loss

Indexed keywords

ENDOGENOUS COMPOUND; IBUPROFEN; PLACEBO; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; BILE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GALLBLADDER CONTRACTION; GALLSTONE; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; WEIGHT REDUCTION;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BILE; CHOLAGOGUES AND CHOLERETICS; CHOLELITHIASIS; DIET, REDUCING; DOUBLE-BLIND METHOD; FEMALE; GALLBLADDER EMPTYING; GASTROINTESTINAL AGENTS; HUMANS; IBUPROFEN; MALE; OBESITY; URSODEOXYCHOLIC ACID; WEIGHT LOSS;

EID: 0029966041     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02093811     Document Type: Article

References (45)

1. Broomfield PH, Chopra R, Sheinbaum RC, Bonorris GG, Silverman A, Schoenfield LJ, Marks JW: Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight. N Engl J Med 319:1567-1572, 1988
2. Liddle RA, Goldstein RB, Saxton J: Gallstone formation during weight reduction dieting. Arch Intern Med 149:1750-1753, 1989
3. Shiffman ML, Sugerman HJ, Kellum JM, Brewer WH, Moore EW: Gallstone formation after rapid weight loss: A prospective study in patients undergoing, gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol 86:1000-1005, 1991
4. Yang H, Petersen GM, Roth M, Schoenfield LJ, Marks JW: Risk factors for gallstone formation during rapid loss of weight. Dig Dis Sci 37:912-918, 1992
5. Marks JW, Bonorris GG, Albers G, Schoenfield LJ: The sequence of biliary events preceding the formation of gallstones in man. Gastroenterology 103:566-570, 1992
6. Bennion LJ, Grundy SM: Effects of obesity and caloric intake on biliary lipid metabolism in man. J Clin Invest 56:996-1011, 1975
7. Afdhal NH, Niu N, Gantz D, Small D, Smith BF: Bovine-gallbladder mucin accelerates cholesterol monohydrate crystal growth in model bile. Gastroenterology 104:1515-1523, 1993
8. Levy PF, Smith BF, LaMont JT: Human gallbladder mucin accelerates nucleation of cholesterol in artificial bile. Gastroenterology 87:270-275, 1984
9. Pemsingh RS, MacPherson BR, Scott GW: Mucus hypersecretion in the gallbladder epithelium of ground squirrels fed a lithogenic diet for the induction of cholesterol gallstones. Hepatology 1267-1271, 1987
10. Lee SP, LaMont JT, Carey MC: Role of gallbladder mucus hypersecretion in the evolution of cholesterol gallstones. J Clin Invest 67:1712-1723, 1981
11. LaMorte WW, LaMont JT, Hale W, Booker ML, Scott TE, Turner B: Gallbladder prostaglandins and lysophospholipids as mediators of mucin secretion during cholelithiasis. Am J Physiol 251:G701-G709, 1986
12. LaMont JT, Smith BF, Moore JR: Role of gallbladder mucin in pathophysiology of gallstones. Hepatology 4:51S-56S, 1984
13. O'Leary DP, LaMorte WW, Scott TE, Booker ML, Stevenson J: Inhibition of prostaglandin synthesis fails to prevent gallbladder mucin hypersecretion in the cholesterol-fed prairie dog. Gastroenterology 101:812-820, 1991
14. Shiffman ML, Shamburek RD, Schwartz CC, Sugerman HJ, Kellum JM, Moore EW: Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology 105:1200-1208, 1993
15. Pomerantz IS, Shaffer EA: Abnormal gallbladder emptying in a subgroup of patients with gallstones. Gastroenterology 88:787-791, 1985
16. Fisher RS, Stelzer F, Rock E, Melmud L: Abnormal gallbladder emptying in patients with gallstones. Dig Dis Sci 27:1019-1024, 1982
17. Pelligrini CA, Ryan T, Broderick W, Way LW: Gallbladder filling and emptying during cholesterol gallstone formation in the prairie dog. Gastroenterology 90:143-149, 1986
18. Hutton SW, Sievert CE, Vennes JA, Duane WC: Inhibition of gallstone formation by sphincterotomy in the prairie dog: Reversal by atropine. Gastroenterology 82:1308-1313, 1982
19. Maizio L, Capone F, Neri M, Mezzetti A, DeAngelis C, Cuccurullo F: Gallbladder kinetics in obese patients. Effect of a regular meal and low-calorie meal. Dig Dis Sci 33:4-9, 1988
20. Vezina WC, Paradis D, Grace M, Zimmer RA, LaMont DD, Rycroft KM, King ME, Hutton LC, Chey WY: Increased volume and decreased emptying of the gallbladder in large (morbidly obese, tall normal, and muscular normal) people. Gastroenterology 98:1000-1007, 1990
21. Stone BG, Ansel HJ, Peterson FJ, Gebhard RL: Gallbladder emptying stimuli in obese and normal-weight subjects. Hepatology 15:795-798, 1992
22. Li YF, Weisbrodt NW, Moody FG, Loelho JC, Gouma DJ: Calcium-induced contraction and contractile protein content of gallbladder smooth muscle after high-cholesterol feeding of prairie dogs. Gastroenterology 92:746-750, 1987
23. Everson GT, Braverman DZ, Johnson ML, Kern F Jr: A critical evaluation of real-time ultrasonography for the study of gallbladder volume and contraction. Gastroenterology 79:40-46, 1980
24. Zak R: Basic Facts for Basic Science. New York; Raven Press; 1990, p 15
25. Thistle JL, Schoenfield LJ: Induced alterations in composition of bile of persons having cholelithiasis. Gastroenterology 61:488-496, 1971
26. Talalay P: Enzymic analysis of steroid hormones. Methods Biochem Anal 8:119-143, 1960
27. Schoenfield LJ, Bonorris GG, Ganz P: Induced alterations in the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in the hamster. J Lab Clin Med 82:858-868, 1973
28. Fiske CH, Subbarow Y: The colorimetric determination of phosphorus. J Biol Chem 66:375-400, 1925
29. Carey MC, Ko G: The importance of total lipid concentration in determining cholesterol solubility in bile and the development of critical tables for calculating percent cholesterol saturation with a correction factor for ursodeoxycholate-rich bile. In Biological Effects of Bile Acids. G Paumgartner, A Stiehl, W Gerok, (eds). Baltimore, University Park Press; 1979, pp 299-308
30. Yamazaki K, LaRusso NE: Biliary proteins: Assessment of quantitative differences between subjects with and without gallstones. Hepatology 7:359A, 1987
31. Perdigoto R, Yamazaki K, LaRusso NE: Biliary glycoproteins: Quantitative differences in subjects with and without gallstones. Hepatology 8:A1257, 1988
32. Kaiser DG, Vangiessen GJ: GLC determination of ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] in plasma. J Pharm Sci 63:219-221, 1974
33. Marks JW, Broomfield P, Bonorris GG, Schoenfield LJ: Factors affecting the measurement of cholesterol nucleation in human gallbladder and duodenal bile. Gastroenterology 101:214-219, 1991
34. Marks JW, Bonorris GG, Schoenfield LJ: The roles of deoxycholate and arachidonate in the pathogenesis of cholesterol gallstones in obese patients during rapid loss of weight. Dig Dis Sci 36:957-960, 1991
35. Everson GT, McKinley C, Mills M, Cippola T, Showalter R, Peterson F: Weight loss in obese women markedly inhibits bile acid synthesis. The metabolic basis for cholesterol gallstone formation? Gastroenterology 106:A889, 1994
36. Shiffman MC, Vickers FF, Stifler LTP, Kaplan GD, 31 Participating HMR Weight Loss Centers: A multicenter, double-blind, placebo-controlled trial of ursodeoxycholic acid (urso) for prevention of gallstone (GS) formation in obese patients during very low calorie diet (VLCD) induced weight reduction. Gastroentcrology 106:A982, 1994
37. Sahlin S, Ake D, Angelin B, Reihner E, Henriksson R, Einarsson K: Mucin in gallbladder bile of gallstone patients: Influence of treatment with chenodeoxycholic acid and ursodeoxycholic acid. Gut 29:1506-1510, 1988
38. Berr F, Schreiber E, Frick U: Interrelationships of bile acid and phospholipid fatty acid species with cholesterol saturation of duodenal bile in health and gallstone disease. Hepatology 16:71-81, 1992
39. Rhodes M, Allen A, Dowling RH, Murphy G, Lennard TWJ: Inhibition of human gallbladder mucus synthesis in patients undergoing cholecystectomy. Gut 33:1113-1117, 1992
40. Northfield TC, Kufer RM, Maudgal DP, Zeutler-Munro PL, Meller ST, Garrie NW, McCready R: Gall-bladder sensitivity to cholecystokinin in patients with gall stones. Br Med J 280:143-144, 1980
41. Thompson JC, Fried GM, Ogden WD, Fagan CJ, Inoue K, Wiener I, Watson LC: Correlation between release of cholecystokinin and contraction of the gallbladder in patients with gallstones. Ann Surg 195:670-676, 1982
42. Musclee AAM, Jansen JBMJ, Driessen WMM, Geuskens LM, Lumars CBHW: Plasma cholecystokinin and gallbladder responses to intraduodenal fat in gallstone patients. Dig Dis Sci 34:353-359, 1939
43. Festi D, Orsini M, LiBassi S, Ceré C, Samgermano A, Pareni M, Babini AC, Mazzella G, Bazzoli F, Aldini R, Roda E: Risk of gallstone formation during rapid weight loss: protective role of gallbladder motility. Gastroenterology 102:A311, 1992
44. O'Donnell LJD, Wilson P, Guest P, Catnach SM, McLean A, Wrekham JEA, Fairclough PD: Indomethacin and postprandial gallbladder emptying. Lancet 339:269-271, 1992
45. Holan KR, Holzbach T, Hermann RE, Cooperman AM, Claffey WJ: Nucleation time: A key factor in the pathogenesis of cholesterol gallstone disease. Gastroenterology 77:611-617, 1979