Mechanisms of glycopeptide resistance in enterococci

Journal of Infection

Volumn 32, Issue 1, 1996, Pages 11-16

  Arthur, M ^a   Reynolds, P E ^b   Depardieu, F ^a   Evers, S ^c   Dutka Malen, S ^a   Quintiliani Jr , R ^a   Courvalin, P ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

DEPSIPEPTIDE; DIPEPTIDASE; LIGASE; OXIDOREDUCTASE; PEPTIDOGLYCAN; POLYPEPTIDE ANTIBIOTIC AGENT; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ENTEROCOCCUS; NONHUMAN; REVIEW; TRANSPOSON;

EID: 0029965852     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-4453(96)80003-X     Document Type: Review

References (20)

1. Arthur M, Molinas C, Courvalin P. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol 1992; 174: 2582-2591.
2. Arthur M, Courvalin P. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother 1993; 37: 1563-1571.
3. Evers S, Reynolds PE, Courvalin P. Sequence of the vanB and ddI genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583. Gene 1994; 140: 97-102.
4. Bugg TDH, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 1991; 30: 10408-10415.
5. Arthur M, Molinas C, Bugg TDH, Wright GD, Walsh CT, Courvalin P. Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci. Antimicrob Agents Chemother 1992; 36: 867-869.
6. Reynolds PE, Depardieu F, Dutka-Malen S, Arthur M, Courvalin P. Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. Mol Microbiol 1994; 13: 1065-1070.
7. Arthur M, Depardieu F, Snaith HM, Reynolds PE, Courvalin P. Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob Agents Chemother 1994; 38: 1899-1903.
8. Gutmann L, Billot-Klein D, Al-Obeid S et al. Inducible carboxypeptidase activity in vancomycin-resistant enterococci. Antimicrob Agents Chemother 1992; 36: 77-80.
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11. Wright GD, Holman TR, Walsh CT. Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry 1993; 32: 5057-5063.
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