A controlled trial with ORG 2766, an ACTH-(4-9) analog, in 50 relatively able children with autism

European Neuropsychopharmacology

Volumn 6, Issue 1, 1996, Pages 13-19

  Buitelaar, Jan K ^a   Dekker, Marjoleine E M ^a   Van Ree, Jan M ^a   Van Engeland, Herman ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Autistic disorder; Endogenous opioids; ORG 2766; Social behavior

Indexed keywords

2 AMINO 4 (METHYLSULFONYL)BUTYRYLGLUTAMYLHISTIDYLPHENYLALANYL DEXTRO LYSYLPHENYLALANINE; CORTICOTROPIN DERIVATIVE; PLACEBO;

ADOLESCENT; AGGRESSION; ARTICLE; AUTISM; BEHAVIOR; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HEADACHE; HUMAN; HYPERACTIVITY; PRIORITY JOURNAL; SCHOOL CHILD; SIDE EFFECT;

EID: 0029965763     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0924-977X(95)00049-U     Document Type: Article

References (21)

1. Althaus, M., Minderaa, R.B. and Dienske, H. (1994) The assessment of individual differences between individual young children with a pervasive developmental disorder by means of behaviour scales which are derived from direct observation. J. Child Psychol. Psychiatry 35, 333-349.
2. Aman, M.G. and Singh, N.N. (1985) Psychometric characteristics of the Aberrant Behavior Checklist. Am. J. Ment. Defic. 89, 492-502.
3. Bachevalier, J. (1994) Medial temporal lobe structures and autism: review of clinical and experimental findings. Neuropsychologia 6, 627-648.
4. Buitelaar, J.K., Van Engeland, H., Van Ree, J.M. and De Wied, D. (1990) Behavioral effects of ORG 2766, a synthetic analog of the adrenocorticotrophic hormone (4-9), in 14 outpatient autistic children. J. Autism Dev. Disord. 20, 467-478.
5. Buitelaar, J.K., Van Engeland, H., De Kogel, C.H., De Vries, H., Van Hooff, J.A.R.A.M. and Van Ree, J.M. (1992a) The adrenocorticotrophic hormone (4-9) analog ORG 2766 in autistic children: effects on the organization of behavior. Biol. Psychiatry 31, 1119-1129.
6. Buitelaar, J.K., Van Engeland, H., De Kogel, C.H., De Vries, H., Van Hooff, J.A.R.A.M. and Van Ree, J.M. (1992b) Deficits in social behavior in autism and their modification by a synthetic adrenocorticotrophic hormone (4-9) analog. Experientia 48, 391-394.
7. Buitelaar, J.K., Van Engeland, H., De Kogel, C.H., De Vries, H., Van Hooff, J.A.R.A.M. and Van Ree, J.M. (1992c) The adrenocorticotrophic hormone (4-9) analog ORG 2766 benefits autistic children: report on a second controlled clinical trial. J. Am. Acad. Child Adolesc. Psychiatry 31, 1149-1156.
8. Castelloe, P. and Dawson, G. (1993) subclassification of children with autism and pervasive developmental disorder - a questionnaire based on Wing subgrouping scheme. J. Autism Dev. Disord. 23, 229-241.
9. Cohen, J. (1960) A coefficient of agreement for nominal scales. Educ. Psychol. Measure. 20, 37-46.
10. De Wied, D. and Jolles, J. (1982) Neuropeptides derived from the pro-opiocortin: behavioral, physiological and neurochemical effects. Physiol. Rev. 62, 976-1059.
11. Hol, T. and Spruijt, B.M. (1992) The MSH/ACTH (4-9) analog ORG 2766 counteracts isolation-induced changes in social behavior via the amygdala. Peptides 13, 541-544.
12. Jacobson, N.S. and Truax, P. (1991) Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J. Consult. Clin. Psychol. 59, 12-19.
13. McDaniel, W.F. (1993) The influence of fragments and analogs of ACTH/MSH upon recovery from nervous system injury. Brain Res. 56, 11-22.
14. Niesink, R.J.M. and Van Ree, J.M. (1983) Normalizing effects of an ACTH 4-9 analog (ORG 2766) on 'disturbed' social behavior of rats: implication of endogeneous opioid systems. Science 221, 960-962.
15. NIMH (1985) CGI (Clinical Global Impression) scale. Psychopharmacol. Bull. 21, 839-842.
16. Noldus, L.P.J.J. (1991) The Observer: a software system for collection and analysis of observational data. Behav. Methods Instruments Computers 23, 415-429.
17. Pigache, R.M. and Rigter, H. (1981) Effects of peptides related to ACTH on mood and vigilance in man. Frontiers Hormone Res. 8, 193-207.
18. Schopler, K., Reichler, R.F., Devellis, R.F. and Daly, K. (1980) Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS), J. Autism Dev. Disord. 10, 91-103.
19. Wing, L. and Gould, J. (1979) Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification. J Autism Dev. Disord. 9, 11-29.
20. Wolterink, G. and Van Ree, J.M. (1989) Opioid systems in the amygdala can serve as substrate for the behavioral effects of the ACTH (4-9) analog Org 2766. Neuropeptides 14, 129-136.
21. Zagon, I.S. and McLaughlin, P.J. (1988) Endogenous opioids systems and neurobehavioral development. In: R.J. Rodgers and S.J. Cooper (Eds.), Endorphins, Opiates and Behavioural Processes. Wiley, New York, pp. 287-309.