Highly selective cleavage of pyroglutamyl-peptide bond in concentrated hydrochloric acid

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 4, 1996, Pages 877-879

  Hashimoto, Tadashi ^a   Saito, Susumu ^a   Ohki, Kazuhiro ^a   Sakura, Naoki ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

cleavage reaction; hydrochloric acid; hydrolysis; pyroglutamyl peptide; pyroglutamyl peptide bond

Indexed keywords

HYDROCHLORIC ACID; NEUROMEDIN U 8;

AMINO ACID SEQUENCE; DOG; DRUG HYDROLYSIS; DRUG STABILITY; MOLECULAR INTERACTION; NONHUMAN; PROTEIN DEGRADATION; REVIEW;

EID: 0029965382     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.877     Document Type: Review

References (5)

1. Hashimoto T., Ohki K., Sakura N., Chem. Pharm. Bull., 43, 2068-2074 (1995).
2. Blombäck B., "Methods in Enzymology," ed. by Hirs C.H.W., Academic Press, New York, Vol 11, 1967, p. 398-411.
3. Saito S., Ohki K., Sakura N., Hashimoto T., Biol. Pharm. Bull., in press.
4. O'Harte F., Bockman C.S., Abel P.W., Conlon J.M., Peptides, 12, 11-15 (1991).
5. Sakura N., Kurosawa K., Hashimoto T., Chem. Pharm. Bull., 43, 1148-1153 (1995).