Effect of a high-protein meal on gabapentin pharmacokinetics

Epilepsy Research

Volumn 23, Issue 1, 1996, Pages 71-76

  Gidal, Barry E ^a,b   Maly, Melissa M ^b   Budde, Jim ^a   Lensmeyer, Gary L ^b   Pitterle, Michael E ^a   Jones, John C ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Drug nutrient interaction; Gabapentin; L amino acid transport system; Pharmacokinetics

Indexed keywords

GABAPENTIN;

ADULT; AMINO ACID TRANSPORT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; EPILEPSY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL;

EID: 0029965332     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(95)00051-8     Document Type: Article

References (18)

1. Alexander, G.M., Schwartzman, R.J., Grothusen, J.R. and Gordon, S.W., Effect of plasma levels of large neutral amino acids and degree of Parkinsonism on the blood-to-brain transport of levodopa in naive and MPTP parkinsonian monkeys, Neurology, 44 (1994) 1491-1499.
2. Pennington, J.A.T. (Ed.), Bowes and Churches Food Values of Portions Commonly Used, 16th ed., J.B. Lippincott Co., Philadelphia, PA, 1994.
3. Bracco, F., Malesani, R., Saladini, M. and Battistin, L., Protein redistribution diet and antiparkinsonian response to levodopa, Eur. Neurol., 31 (1991) 68-71.
4. Collarini, E.J. and Oxender, D.L., Mechanisms of transport of amino acids across membranes, Ann. Rev. Nutr., 7 (1987) 75-90.
5. Killberg, M.S., Stevens, B.R. and Novak, D.A., Recent advances in mammalian amino acid transport, Ann. Rev. Nutr., 13 (1993) 137-165.
6. Lennernas, H., Ahrenstedt, O. and Ungell, A.-L., Intestinal drug absorption during induced water absorption in man: A mechanistic study using antipyrine, atenolol and enalaprilat, Br. J. Clin. Pharmacol., 37 (1994) 589-596.
7. Lensmeyer, G., Kempf, T., Gidal, B. and Weibe, D., Optimized method for determination of gabapentin in serum by HPLC, Ther. Drug Monit., 17 (1995) 251-258.
8. McLean, M.J., Clinical pharmacokinetics of gabapentin, Neurology, 44 (Suppl. 5) (1994) S17-S22.
9. Pardridge, W.M. and Choi, T.B., Neutral amino acid transport at the human blood-brain barrier, Fed. Proc., 45 (1986) 2073-2078.
10. Pinchus J.H. and Barry, K.M., Plasma levels of amino acids correlate with motor fluctuations in Parkinsonism, Arch. Neurol., (1987) 44 1006-1009.
11. Riley, D. and Lang, A.E., Practical application of a low protein diet for Parkinsons disease, Neurology, 38 (1988) 1026-1031.
12. Shulkin, B.L., Betz, A.L., Koeppe, R.A. and Agranoff, B.W., Inhibition of neutral amino acid transport across the human blood-brain barrier by phenylalanine, J. Neurochem., 64 (1995) 1252-1257.
13. Stevens, B.R., Vertebrate intestine apical membrane mechanisms of organic nutrient transport, Am. J. Physiol., 263 (32) (1992) R458-R463.
14. Stevens, B.R., Amino acid transport in intestine. In: M.S. Killberg and D. Haussinger (Eds.), Mammalian Amino Acid Transport, Plenum Press, New York, 1992.
15. Stewart, B.H., Kugler, A.R., Thompson, P.R. and Bockbrader, H.N., A saturable transport mechanism in intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma, Pharm. Res., 10 (2) (1993) 276-282.
16. Thurlow, R.J., Brown, J.P., Gee, N.S., Hill, D.R. and Woodruff, G.N., [3H]Gabapentin may label a system-L like neutral amino acid carrier in brain, Eur. J. Pharmacol., 247 (1993) 341-345.
17. Welling, P.G., Interactions affecting drug absorption, Clin. Pharmacokin., 9 (1984) 404-434.
18. Welty, D.F., Schielke, G.P., Vartanian, M.G. and Taylor, C.P., Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate, Epilepsy Res., 16 (1993) 175-181.