Effects of long-term growth hormone (GH) and triiodothyronine (T3) administration on functional hepatic nitrogen clearance in normal man

Journal of Hepatology

Volumn 24, Issue 3, 1996, Pages 313-319

  Wolthers, Troels ^a   Grøfte, Thorbjørn ^a   Møller, Niels ^a   Vilstrup, Hendrik ^a   Jørgensen, Jens Otto Lunde ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

amino acids; growth hormone; nitrogen; protein metabolism; thyroid hormone

Indexed keywords

AMINO ACID; GROWTH HORMONE; HUMAN GROWTH HORMONE; LIOTHYRONINE; NITROGEN; PLACEBO; SOMATOMEDIN C;

ADULT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; HUMAN; LIVER METABOLISM; MALE; NITROGEN URINE LEVEL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN METABOLISM; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029965305     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80010-9     Document Type: Article

References (37)

1. Guler HP, Zapf J, Froesch ER. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med 1987; 317: 137-40.
2. Jacob R, Barret E, Piewe G, Fagin KD, Sherwin RS. Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. J Clin Invest 1989; 83: 1717-23.
3. Møller N, Pørksen N, Ovesen P, Alberti KGMM. Effects of short-term fasting on basal and growth hormone pulse stimulated substrate metabolism in humans. Horm Metab Res 1993; 25: 175-9.
4. Kupfer SR, Underwood LE, Baxter RC, Clemmons DR. Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously. J Clin Invest 1993; 91: 391-6.
5. Wolthers T, Groefte T, Jørgensen JOL, Møller N, Vahl N, Christiansen JS, Vilstrup H. Effects of growth hormone (GH) administration on functional hepatic nitrogen clearance: studies in normal man and GH-deficient patients. J Clin Endocrinol Metab 1994; 78: 1220-4.
6. Dahms WT, Owens RP, Kalhan SC, Kerr DS, Danish RK. Urea synthesis, nitrogen balance, and glucose turnover in growth-hormone-deficient children before and after growth hormone administration. Metabolism 1989; 38: 197-203.
7. Burini R, Santidrian S, Moreyra M, Brown P, Munro HN, Young VR. Interaction of thyroid status and diet on muscle protein breakdown in the rat, as measured by N-methylhistidin excretion. Metabolism 1981; 30: 679-87.
8. Crispell KR, Parson W, Hollifield G. A study of the rate of protein synthesis before and during the administration of L-triiodthyronine to patients with myxedema and healthy volunteers using N-15 glycine. J Clin Invest 1956; 35: 164-9.
9. Georges LP, Santangelo RP, Mackin JF, Conray JJ. Metabolic effects of propanolol in thyrotoxicosis. I. Nitrogen, calcium, and hydroxyproline. Metabolism 1975; 24: 11-8.
10. 3 administration on muscle protein catabolism during fasting as measured by 3-methylhistidine excretion. Metabolism 1979; 28: 805-13.
11. Carter WJ, Faas FH, Wynn JO. Role of starvation in production of creatinuria in experimental hyperthyroidism. Metabolism 1977; 26: 1243-50.
12. Møller J, Jørgensen JOL, Møller N, Christiansen JS, Weeke J. Effects of growth hormone administration of fuel oxidation and thyroid function in normal man. Metabolism 1992; 41: 728-31.
13. Vilstrup H. On urea synthesis regulation in vivo. Danish Medical Bulletin 1986; 36: 415-29.
14. Fawcett JK, Scott JE. A rapid and precise method for determination of urea. J Clin Path 1960; 13: 156-9.
15. Goodwin JF. Spectrophotometric quantisation of plasma and urinary amino nitrogen with fluorodinitribenzene. Stand Meth Clin Chem 1970; 6: 89.
16. Ørskov H, Thomsen HG, Yde H. Wick-chromatography for a rapid and reliable immunoassay of insulin, glucagon and growth hormone. Nature 1968; 219: 193-7.
17. Weeke J, Ørskov H. Evaluation of thyroid function. In: Alberti KGMM ed. Recent Advances in Clinical Biochemistry. New York: Churchill Livingstone, 1978: 111-28.
18. Weeke J, Ørskov H. Ultrasensitive radioimmunoassay for direct determination of free triidothyronine concentration in serum. Scand J Clin Lab Invest 1975; 35: 237-44.
19. Ho RJ, Meng HC. A simple and ultra-sensitive method for determination of free fatty acids by radiochemical assay. Ann Biochem 1969; 31: 426-30.
20. Hamberg O, Vilstrup H. A rapid method for determination of hepatic amino-N to urea-N (the functional hepatic nitrogen clearance). Scand J Clin Lab Invest 1994; 54: 377-83.
21. Døssing M, Poulsen HE, Andreasen PB, Tygstrup N. A simple method for determination of antipyrine clearance. Clin Pharmacol Ther 1982; 32: 392-6.
22. Vilstrup H. Synthesis of urea after stimulation with amino acids: relation to liver function. Gut 1980; 21: 990-5.
23. Vilstrup H, Hansen BA, Almdal TP, Glucagon increases hepatic efficacy for urea synthesis. J Hepatol 1990; 10: 46-50.
24. Vilstrup H, Iversen J, Tygstrup N. Glucoregulation in acute liver failure. Eur J Clin Invest 1986; 16: 193-7.
25. Marchesini G, Fabbri A, Bianchi GP, Motta E, Bugianesi E, Urbini D, Pascoli A, Lodi A. Hepatic conversion of amino nitrogen to urea nitrogen in hypothyroid patients and upon L-thyroxine therapy. Metabolism 1993; 42: 1263-9.
26. Bradley SE, Stephan F, Coelho JB, Reville P. The thyroid and the kidney. Kidney Int 1974; 6: 346.
27. Katz AI, Emmanouel DS, Lindheimer MD. Thyroid hormone and the kidney. Nephron 1975; 15: 223.
28. Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, Sherman BM. Effects of short-term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab 1986; 70: 519-27.
29. Ho KY, Weissberger AJ. the antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system. Metabolism 1990; 39: 133-7.
30. Hamberg O, Nielsen K, Vilstrup H. Effects of an increase in protein intake on hepatic efficacy for urea synthesis in healthy subjects and patients with cirrhosis. J Hepatol 1992; 14 (2-3): 237-43.
31. Heindorff H, Hoist JJ, Almdal T, Vilstrup H. Effect of glucagon immunoneutralisation on the increase in urea synthesis after hysterectomia in rats. Eur J Clin Invest 1993; 23: 166-70.
32. Møller N, Jørgensen JOL, Alberti KGMM, Flyvbjerg A, Schmitz O. Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 1990; 70: 1179-86.
33. Marchesini G, Fabbri A, Bianchi GP, Motta E, Giovanelli P, Urbini D, Lodi A. Hepatic conversion of amino-nitrogen to urea in thyroid diseases. II. A study in hyperthyroid patients. Metabolism 1994; 43: 1023-9.
34. Grøfte T, Wolthers T, Jensen DS, Møller N, Jørgensen JOL, Ørskov H, Vilstrup H. Hepatic amino nitrogen conversion and organ N-contents in hypothyroidism, upon thyroxine replacement, and in hyperthyroid rats. J Hepatol 1995: accepted.
35. Grøfte T, Wolthers T, Møller N, Jørgensen JOL, Flyvbjerg A, Ørskov H, Vilstrup H. Moderate hyperthyroidism reduces both liver amino-N conversion and muscle N contents in rats. Eur J Clin Invest 1995: in press.
36. Valcavi R, Dieguez C, Zini M, Muruais C, Casanueva F, Portioli I. Influence of hyperthyroidism on growth hormone secretion. Clin Endocrinol 1993; 38: 515-22.
37. Miell JP, Taylor AM, Zini M, Maheshwari HG, Ross RJ, Valcavi R. Effects of hypothyroidism and hyperthyroidism on insulin-like growth factors and growth hormone- and IGF-binding proteins. J Clin Endocrinol Metab 1993; 76: 950-5.