Biomarkers of exposure to low concentrations of benzene: A field assessment

Occupational and Environmental Medicine

Volumn 53, Issue 5, 1996, Pages 328-333

  Ong, C N ^a   Kok, P W ^a   Ong, H Y ^a   Shi, C Y ^a   Lee, B L ^a   Phoon, W H ^b   Tan, K T ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Ministry of Manpower Government of Singapore   (Singapore)

Author keywords

Biomonitoring; Specificity; threshold limit values

Indexed keywords

BENZENE; BIOLOGICAL MARKER; CATECHOL; HYDROQUINONE; PETROLEUM; PHENOL;

ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; OCCUPATIONAL EXPOSURE; OIL INDUSTRY; PRIORITY JOURNAL; SINGAPORE; URINALYSIS;

EID: 0029964350     PISSN: 13510711     EISSN: None     Source Type: Journal    
DOI: 10.1136/oem.53.5.328     Document Type: Article

References (22)

1. Yardley-Jones A, Anderson D, Parke D. The toxicity of benzene and its metabolism and molecular pathology in human risk assessment. Br J Ind Med 1991;48:437-44.
2. Rinsky RA. Benzene and leukemia: an epidemiologic risk assessment. Environ Health Perspect 1989;82:189-92.
3. Environmental Health Executive. Occupational exposure limits. London: HMSO, 1994. (EH40/94.)
4. American Conference of Governmental Industrial Hygienists. Notice of intended changes - benzene. Appl Occup Environ Hyg 1990;5:453-9.
5. Ong CN, Lee BL. Determination of benzene and its metabolites: application in biological monitoring of environmental and occupational exposure to benzene. J Chromatogr 1994;660:1-22.
6. Inoue O, Seiji K, Kasahara M, Nakatsuka H, Watanabe T, Yin SG, et al. Determination of catechol and quinol in the urine of workers exposed to benzene. Br J Ind Med 1988;45:487-92.
7. Lee BL, Ong HY, Shi CY, Ong CN, Simultaneous determination of hydroquinone, catechol and phenol in urine using high-performance liquid chromatography with fluorimetric detection. J Chromatogr 1993;619:259-66.
8. Ghittori S, Fiorentino ML, Maestri L, Cordioli G, Imbriani M, Urinary excretion of unmetabolized benzene as an indicator of benzene exposure. J Toxicol Environ Health 1993;38:233-43.
9. Kok PW, Ong CN. Blood and urinary benzene determined by headspace gas chromatography with photoionization detection. Int Arch Occup Environ Health 1994;66: 195-201.
10. van Sittert NJ, Boogaard PJ, Beulink GDJ. Application of the urinary S-phenylmercapturic acid test as a biomarker for low levels of exposure to benzene in industry. Br J Ind Med 1993;50:460-9.
11. Boogaard PJ, van Sittert NJ. Biological monitoring of exposure to benzene: a comparison between S-phenyl mercapturic acid, trans, trans-muconic acid, and phenol. Occup Environ Med 1995;52:611-20.
12. Inoue O, Seiji H, Nakasuka T, Watanabe SN, Yin SN, Li GL, et al. Urinary tt-muconic acid as an indicator of exposure to benzene. Br J Ind Med 1989;46:122-7.
13. Lee BL, New AL, Kok PW, Ong HY, Shi CY, Ong CN. Urinary trans, trans-muconic acid determined by liquid chromatography: application in biological monitoring of benzene exposure. Clin Chem 1993;39:1788-92.
14. Lauwerys RR, Buchet JP, Andrien F. Muconic acid in urine: a reliable indicator of occupational exposure tobenzene. Am J Ind Med 1994;25:297-300.
15. Ong CN, Kok PW, Lee BL, Shi CY, Ong HY, Chia KS, et al. Evaluation of biomarkers for occupational exposure to benzene. Occup Environ Med 1995;52:528-33.
16. Ong CN, Lee BL, Shi CY, Ong HY, Lee HP. Elevated levels of benzene-related compounds in the urine of cigarette smokers. Int J Cancer 1994;59:177-80.
17. Ong CN, Chia SE, Phoon WH, Tan KT. Biological monitoring of occupational exposure to tetrahydrofuran. Br J Ind Med 1991;48:616-21.
18. Ghittori S, Imbrani E, Pezzagno G, Capodaglio E. The urinary concentrations of solvents as a biological equivalent exposure limit for nine solvents. Am Ind Hyg Assoc J 1987;48:786-90.
19. Boeniger MF, Lowry LK, Rosenberg J. Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustment: a review. Am Ind Hyg Assoc J 1993;54:615-27.
20. Witz G, Gad SC, Tice RR, Oshiro Y, Piper CE, Goldstein BD. Genetic toxicity of the benzene metabolites trans, trans-mucoaldehyde in mammalian and bacterial cells. Mutat Res 1990;240:295-306.
21. Irons RD, Stillman WS, Colagiovanni DB, Henry VA. Svnergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating factor in vitro. Proc Nat Acad Sci USA 1992;89:3691-5.
22. Sze CC, Shi CY, Ong CN. Cytotoxicity and DNA strand breaks induced by benzene and its metabolites in Chinese hamster ovary cells. J Appl Toxicol (in press).