Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women

European Journal of Nuclear Medicine

Volumn 23, Issue 11, 1996, Pages 1473-1477

  Carnevale, Vincenzo ^a   Frusciante, Vincenzo ^a   Scillitani, Alfredo ^a   Modoni, Sergio ^a   Pileri, Mauro ^a   Chiodini, Iacopo ^a   Dicembrino, Franca ^a   Romagnoli, Elisabetta ^b   Minisola, Salvatore ^b,c  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

Author keywords

Aging; Bone turnover; Global skeletal uptake

Indexed keywords

BIOCHEMICAL MARKER; MEDRONIC ACID; TECHNETIUM 99M;

ADULT; AGED; AGING; ARTICLE; BONE METABOLISM; BONE TURNOVER; DRUG UPTAKE; FEMALE; HUMAN; HUMAN EXPERIMENT; KIDNEY FUNCTION; NORMAL HUMAN; OSSIFICATION;

ADULT; AGED; AGED, 80 AND OVER; AGING; BONE AND BONES; BONE REMODELING; FEMALE; HUMANS; MIDDLE AGED; POSTMENOPAUSE; TECHNETIUM TC 99M MEDRONATE;

EID: 0029963518     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01254471     Document Type: Article

References (13)

1. Fogelman I, Bessent RG, Turner JG, Citrin DL, Boyle IT, Greig WR. The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease. J Nucl Med 1978; 19: 270-275.
2. Caniggia A, Vattimo A. Kinetics of 99m technetium-tin-methylene-diphosphonate in normal subjects and pathological conditions: a simple index of bone metabolism. Calcif Tissue Int 1980; 30: 5-13.
3. D'Addabbo A, Rubini G, Mele M, Lauriero F. A new method for assessing 99Tc-m-MDP bone uptake from a bone scan image: quantitative measurement of radioactivity in global skeletal regions of interest. Nucl Med Commun 1992; 13: 55-60.
4. Rubini G, Lauriero F, Rubini D, D'Addabbo A. 99-Tc-m-MDP global skeletal uptake and markers of bone metabolism in patients with bone diseases. Nucl Med Commun 1993; 14: 567-572.
5. Sorenson JA. Nuclear medicine tomography: principles. In: Sorenson JA, Phelps ME, eds. Physics in nuclear medicine. New York: Grune & Stratton; 1987: 391-423.
6. Goans RE, Abrams SA, Vieira NE, Marini JC, Perez MD, Yergey AL. A three-hour measurement to evaluate bone calcium turnover. Bone 1995; 16: 33-38.
7. Eastell R, Delmas PD, Hodgson SF, Eriksen EF, Mann KG, Riggs BL. Bone formation rate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers. J Clin Endocrinol Metab 1988; 67: 741-748.
8. 99mTc-diphosphonate. Relation to biochemical indices of bone turnover and to total body calcium. Eur J Nucl Med 1987; 13: 32-35.
9. Galasko CSB. The pathophysiological basis for skeletal scintigraphy. In: Galasko CSB, Weber DA, eds. Radionuclide scintigraphy in orthopedics. Edinburgh: Churchill Living-stone; 1984; 34-53.
10. Sahni M, Guenther HL, Fleish H, Collin P, Martin J. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest 1993; 91: 2004-2011.
11. Hyldstrup L, Clemmensen I, Jensen BA, Transbol I. Non-invasive evaluation of bone formation: measurements of serum alkaline phosphatase. whole body retention of diphosphonate and serum osteocalcin in metabolic bone disorders and thyroid disease. Scand J Clin Lab Invest 1988; 48: 611-619.
12. Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 1994; 79: 1693-1700.
13. Kanis JA. Treatment of osteoporosis in elderly women. Am J Med 1995; 98 Suppl 2A: 60S-66S.