Metabolism of TV-alkyl and cyclic nitrosamines in freshly isolated rat hepatocytes

In Vitro and Molecular Toxicology: Journal of Basic and Applied Research

Volumn 9, Issue 2, 1996, Pages 149-155

  Miyajima, A ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPANOL; 3 METHYLCHOLANTHRENE; NITROSAMINE; PHENOBARBITAL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; LIVER CELL; MALE; METABOLIC RATE; METABOLISM; NONHUMAN; RAT; SEX DIFFERENCE;

EID: 0029963405     PISSN: 10979336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. GUTTENPLAN, J.B. (1987). Structure-activity relationships in metabolism and mutagenecities of N-nitrosamines, in: The Relevance of Nitroso Compounds to Human Cancer Exposures & Mechanisms. I.K. O'Neil, J. Chen, and H. Bartsch (eds.) IARC Publications: Lyon, France, pp. 129-131.
2. HECHT, S.S., YOUNG-SCIAME, R., and CHUNG, F.L. (1992). Reaction of α-acetoxy-N-nitrosopiperidine with deoxyguanosine: Oxygen-dependent formation of 4-oxo-2-pentenal and a l,N2-ethenodeoxyguanosine adduct. Chem. Res. Toxicol. 5, 706-712.
3. Kato, R., Onoda, K., and Takayanagi, M. (1970). Species and sex differences in the substrate induced spectral change of P-450 in relation to the activity of drug oxidation in liver microsomes. Jpn. J. Pharmacol. 20, 157-163.
4. KAWANISHI, T., OHNO, Y., TAKAHASHI, A., TAKANAKA, A., KASUYA, Y., and OMORI, Y. (1984). Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats. Arch. Toxicol. 56, 7-11.