Two investigational glycylcyclines, DMG-DMDOT and DMG-MINO: Antimicrobial activity studied against gram-positive species

Diagnostic Microbiology and Infectious Disease

Volumn 24, Issue 1, 1996, Pages 53-57

  Johnson, David M ^a   Jones, Ronald N ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 DEOXY 7 DIMETHYLAMINO 9 (N,N DIMETHYLGLYCINAMIDO) 6 NORTETRACYCLINE; 6 DEOXY 9 (N,N DIMETHYLGLYCINAMIDO) 6 NORTETRACYCLINE; CHLORAMPHENICOL; CL 331002; CL 331928; ERYTHROMYCIN; GLYCYLCYCLINE DERIVATIVE; MINOCYCLINE; OXACILLIN; TEICOPLANIN; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

BACTERICIDAL ACTIVITY; CONTROLLED STUDY; ENTEROCOCCUS; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; STAPHYLOCOCCUS; STREPTOCOCCUS;

ANTI-BACTERIAL AGENTS; CHLORAMPHENICOL; ERYTHROMYCIN; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; MOLECULAR STRUCTURE; TEICOPLANIN; TETRACYCLINES; VANCOMYCIN;

EID: 0029963150     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/0732-8893(95)00250-2     Document Type: Article

References (14)

1. Ballows A, Hausler WJ, Herrmann KL, Isenberg HD (1991) Manual of Clinical Microbiology, 5th edition. American Society of Microbiology.
2. Chopra I, Hawkey PM, Hinton M (1992) Tetracyclines, molecular, and clinical aspects. J Antimicrob Chemother 29: 245-277.
3. Duggar BM (1948) Aureomycin: a product of the continuing search for new antibiotics. Ann NY Acad Sci 51:177-181.
4. Eliopoulos GM (1993) Increasing problems in the therapy of enterococcal infections. Eur J Clin Microbiol Infect Dis 12:409-412.
5. Eliopoulos GM, Wennersten CB, Cole G, Moellering RC (1994) In vitro activities of two glycylcyclines against Gram-positive bacteria. Antimicrob Agents Chemother 38: 1096-1102.
6. Fraise AP, Brenwald N, Andres JM, Wise R (1995) In vitro activity of two glycylcyclines against enterococci resistant to other agents. J Antimicrob Chemother 35:877-881.
7. Goldstein FW, Kitzis MD, Acar JF (1994) N,N-Dimethylglycylamido derivative of minocycline and 6-demethyl-6-deoxytetracycline, two new glycylcyclines highly effective against tetracycline-resistant Gram-positive cocci. Antimicrob Agents Chemother 38: 2218-2220.
8. Levy SB (1989) Evaluation and spread of tetracycline resistance determinants. J Antimicrob Chemother 24:1-3.
9. National Committee for Clinical Laboratory Standards (NCCLS) (1993) Standard methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically: approved standard M7-A3. Villanova, PA: NCCLS.
10. Speer BS, Shoemaker NB, Salyers AA (1992) Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance. Clin Microbiol Rev 5:387-399.
11. Sum PE, Lee VJ, Testa RT, Hlavka JJ, Ellistrad GA, Bloom JD, Gluzman Y, Tally FP (1994) Glycylcyclines: I. A new generation of potent antibacterial agents through modifications of 9-aminotetracyclines. J Med Chem 37:184-188.
12. Tally FT, Ellestad GA, Testa RT (1995) Glycylcyclines: a new generation of tetracyclines. J Antimicrob Chemother 35:449-452.
13. Testa RT, Petersen PF, Jacobus NV, Sum P, Lee VJ, Tally F (1993) In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Antimicrob Agents Chemother 37:2270-2277.
14. Wise R, Andres JM (1994) In vitro activities of two glycylcyclines. Antimicrob Agents Chemother 38:1096-1102.