Side-chain derivatives of biologically active nucleosides. Part 2: Synthesis and anti-HIV activity of 5′-C-methyl derivatives of 3′-fluoro-3′-deoxythymidine

Antiviral Chemistry and Chemotherapy

Volumn 7, Issue 3, 1996, Pages 173-177

  Hiebl, J ^a,d   Zbiral, E ^a   Von Janta Lipinski, M ^b   Balzarini, J ^c   De Clercq, E ^c  

^a INSTITUT FÜR ORGANISCHE CHEMIE   (Austria)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d Nycomed Holdings AS   (Austria)

Author keywords

3 fluoro 3 deoxythymidine; 5 C methyl nucleosides; AIDS; FLT; Reverse transcriptase

Indexed keywords

1 (3' FLUORO 2',3',6' TRIDEOXY ALPHA LEVO TALOFURANOSYL)THYMINE; 1 (3' FLUORO 2',3',6' TRIDEOXY BETA DEXTRO ALLOFURANOSYL)THYMINE; 3' FLUORO 3' DEOXYTHYMIDINE DERIVATIVE; 3' FLUOROTHYMIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA VIRUS; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RNA VIRUS; STEREOSPECIFICITY;

EID: 0029962155     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029600700308     Document Type: Article

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