Solvent and plasticizer influences on ethylcellulose-microcapsules

Journal of Microencapsulation

Volumn 13, Issue 3, 1996, Pages 307-318

  Palomo, M E ^a   Ballesteros, M P ^a   Frutos, P ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Diclofenac sodium; Drug release; Ethylcellulose; Microcapsule; Plasticizer

Indexed keywords

ACETONE; ALCOHOL; CHLORBUTOL; CHLOROFORM; DICLOFENAC; ETHYL CELLULOSE; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC SOLVENT; PLASTICIZER; SOLVENT; TOLUENE;

ARTICLE; DRUG INACTIVATION; DRUG RELEASE; MICROCAPSULE; MICROENCAPSULATION; PERMEABILITY; STOMACH JUICE; TEMPERATURE SENSITIVITY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAPSULES; CELLULOSE; DICLOFENAC; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; MICROSCOPY; PERMEABILITY; PHTHALIC ACIDS; PLASTICIZERS; POLYMERS; SOLVENTS;

EID: 0029962018     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.3109/02652049609026018     Document Type: Article

References (26)

1. AHMED, S. M., SALEH, S. I., ABDEL-RAHMAN, S. I., KHIDR, S. H., ABOUTALER, A. E. and ALI, A. H., 1992, Preparation and release kinetics of ethylcellulose walled microcapsules containing phenazopyridine hydrochloride dispersed in polymethyl-methacrylate matrices. STP Pharma Sciences, 3(2), 205-209.
2. ARSHADY, R., 1991, Preparation of biodegradable microspheres and microcapsules: 2. Polylactides and related polyesters. Journal of Controlled Release, 17, 1-22.
3. BODMEIER, R, WANG, H., and HERRMAN, J., 1994, Microencapsulation of clorpheniramine maleate, a drug with intermediate solubility properties, by a non-aqueous solvent evaporation technique. STP Pharma Sciences, 4(4), 275-281.
4. CHEMTOB, C., 1987, Microencapsulation avec l'ethylcellulose. Rôle et effects d'agents dits 'Protecteurs ou inducteurs de la coacervation'. STP Pharma Sciences, 3(5), 418-424.
5. COMBES, A., 1989, Etude d'excipients utilisés dans l'industrie pharmaceutique. STP Pharma Sciences, 5(11), 766-790.
6. DEASY, P. B., 1984, Microencapsulation and related drug processes (New York: Marcel Dekker) 40 pp.
7. DELGAY, F., SAUTEREAV, A. M., ALLIE-DARAM, S. J., and COMBES, A., 1992, Preparation and properties of enteric microcapsules containing RH-polypeptide, a protein partially purified from erythrocyte membranes. 6th International Conference on Pharmaceutical Technology. AGPI, 2, 287-293.
8. DONBROW, M., and BENITA, S., 1982, Release kinetics of sparingly soluble drugs from ethylcellulose walled microcapsules: Salicylamide microcapsules. Journal of Pharmacy and Pharmacology, 34, 547-551.
9. FAULI, C., 1993, Tratado de Farmacia Galénica (Madrid: Luzán) pp. 593-597.
10. HASAN, M., NAJIB, N., STJLEIMAN, M., Y-EL-SAYED, and ABDEL-HAMID, M., 1992, In vitro and in vitro evaluation of sustained release and enteric coated microcapsules of diclofenac sodium. Drug Development and Industrial Pharmacy, 18(18), 1981-1988.
11. KAWASHIMA, Y., NIWA, T., HANDA, T., TAKUECHI, H., IWGAMOTO, T., and ITOH, K., 1989, Preparation of controlled release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method. Journal of Pharmaceutical Sciences, 78(1), 68-72.
12. KONDO, A., 1979, Microcapsule processing and technology (New York: Marcel Dekker) pp. 90, 119.
13. KURZ, T., and FüHRER, C., 1992, Investigations on ethylcellulose as an additive for sustained-release formulation. 6th International Conference on Pharmaceutical Technology. APGI, 3, 333-339.
14. LIN, S., and KAO, Y., 1991, Tablet formulation design of spray dried sodium diclofenac enteric coated microcapsules. Proceedings of International Symposium. Controlled Releases Bioactive Materials, 18, 155-156.
15. MAHARAJ, I., NAIRN, J. C., and CAMPBELL, J. B., 1984, Simple rapid method for the preparation of enteric-coated microspheres. Journal of Pharmaceutical Sciences, 73(1), 39-42.
16. MOLDENHALTER, M. G., and NAIRN, J. G., 1990, Formulation parameters affecting the preparation and properties of microencapsulated ion-exchanged resins containing theophylline. Journal of Pharmaceutical Sciences, 79(8), 659-666.
17. NAVARRO, A., 1989, Estudio de películas poliméricas utilizadas en la liberatión controlada de medicamentos. Memoria de Licenciatura.
18. NOKHODCHI, A., and FARID, D., 1992, Effect of various factors on microencapsulation of acetyl salicylic acid by a non-solvent addition method. STP Pharma Sciences, 2(3), 279-283.
19. PETERS, H. J. W., and VAN BOMMELL, E. M. G., 1992, Effect of alingate properties on the microencapsulation process of oils. 6th International Conference on Pharmaceutical Technology. AGPI, 2, 270-279.
20. RACZ, I., 1989, Drug Formulation (Budapest, Hungary: J. Wiley) pp. 352-386
21. SHUKLA, A. J., and PRICE, J. C., 1991, Effect of drug loading and molecular weight of cellulose acetate proprionate on the release characteristics of theophylline microspheres. Pharmaceutical Research, 8(11), 1396-1400.
22. TAKAHATA, H., OSAWA, T., and KOBAYASHI, M., 1992, Effect of polymer species on microencapsulation by a surface neutralization method. Chemical Pharmaceutical Bulletin, 73(12), 1721-1724.
23. VIDMAR, V., and JALSENJAK, J., 1983, Influence of drug partition coefficient and pH value of sink solution on permeation from porous thick-walled ethylcellulose microcapsules. Journal of Pharmacy and Pharmacology, 35, 482-483.
24. VIDMAR, V., JALSENJAK, J., and KONDO, T., 1982, Volume of water-filled pores in the ethylcellulose membrane and the permeability of microcapsules. Journal of Pharmacy and Pharmacology, 34, 411-414.
25. WEISS, G., KNOCH, A., LAICHER, A., STANISLAUS, F., and DANIELS, R., 1993, Influence of polymer charge density on the simple coacervation of cellulose acetate phthalate. European Journal of Pharmaceutics and Biopharmaceutics, 39(6), 239-243.
26. ZINUTTI, C., KEDZIEREWICZ, F., PICARD, L., BARBERI, M., MERLIN, J. L., HOFFMAN, M., and MAINCENT, P., 1992, Mise au point de microsphères d'ethylcellulose chargées en 5-fluororacile, etude in vitro et in vivo. 6th International Conference on Pharmaceutical Technology. APGI, 2, 262-267.