Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 743-750

  John, Susan ^a   Marais, Richard ^b   Child, Ryan ^a   Light, Yvonne ^b   Leonard, Warren J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING SITE; CELL SPECIFICITY; GENE EXPRESSION; GENE INDUCTION; GENETIC REGULATION; GENETIC TRANSCRIPTION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; RECEPTOR AFFINITY; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CONSENSUS SEQUENCE; DNA PRIMERS; DNA-BINDING PROTEINS; DROSOPHILA; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HIV LONG TERMINAL REPEAT; HIV-1; HIV-2; INSECTS; INTERLEUKIN-3; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-2; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSFECTION;

EID: 0029961623     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.743     Document Type: Article

References (30)

1. Wasylyk, B., S.L. Hahn, and A. Giovane. 1993. The Ets family of transcription factors. Eur. J. Biochem. 211:7-18
2. Macleod, K., D. Leprince, and D. Stehelin. 1992. The Ets gene family. Trends Biochem. Sci. 7:251-256.
3. Watson, D.K., F.E. Smyth, D.M. Thompson, J.Q. Cheng, J.R. Testa, T.S. Papas, and A. Seth. 1992. The ERG/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. Cell Growth & Diff. 3:705-713.
4. Wang, C.-Y., B. Petryniak, I.-C. Ho, C.B. Thompson, and J.M. Leiden. 1992. Evolutionanly conserved Ets family members display distinct DNA binding specificities. J. Exp. Med. 175:1391-1399.
5. Gottschalk, L.R., D.M. Giannola, and S.G. Emerson. 1993. Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites. J. Exp. Med. 178:1681-1692.
6. Wang, C.-Y., A.G. Bassuk, L.H. Boise, C.B. Thompson, R. Bravo, and J.M. Leiden. 1994. Activation of the granulocyte-macrophage colony stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors. Mol. Cell. Biol. 14:1153-1159.
7. Dudek, H., R.V. Tantravahi, V.N. Rao, E.S.P. Reddy, and E.P. Reddy. 1992. Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter. Proc. Natl. Acad. Sci. USA. 89:1291-1295.
8. TCF. Nature (Lond.), 354: 531-534.
9. Thompson, C.C., T.A. Brown, and S.L. McKnight. 1991. Convergence of Ets- and Notch-related structural motifs in a heteromeric DNA binding complex. Science (Wash. DC). 253:762-768.
10. Gegonne, A., R. Bosselut, R.B. Aimee, and J. Ghysdael. 1993. Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1. EMBO (Eur. Mol. Biol. Organ.) J. 12:1169-1178.
11. Wotton, D., J. Ghysdael, S. Wang, N.A. Speck, and M.J. Owen. 1994. Cooperative binding of Ets-1 and core binding factor to DNA. Mol. Cell. Biol. 14:840-850.
12. Pongubala, J.M.R., S. Nagulapalli, M.J. Klemz, S.R. McKercher, R.A. Maki, and M.L. Atchison. 1992. PU.1 recruits a second nuclear factor to a site important for immunoglobulin κ 3′ enhancer activity. Mol. Cell. Biol. 12:368-378.
13. Dalton, S., and R. Treisman. 1992. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell 68:597-612.
14. Thompson, C.B., C.Y. Wang, I.C. Ho, P.R. Bohjanen, B. Petryniak, C.H. June, S. Miesfeldt, L. Zhang, G.J. Nabel, B. Karpinski, and J.M. Leiden. 1992. cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol. Cell. Biol. 12:1043-1053.
15. Wang, C.-Y., B. Petryniak, C.B. Thompson, W.G. Kaelin, and J.M. Leiden. 1993. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. Science (Wash. DC). 260:1330-1335.
16. Wurster, A.L., G. Siu, J. M. Leiden, and S.M. Hedrick. 1994. Elf-1 binds a critical element in a second CD4 enhancer. Mol. Cell. Biol. 14:6452-6463.
17. John, S., R.B. Reeves, J.X. Lin, R. Child, J.M. Leiden, C.B. Thompson, and W.J. Leonard. 1995. Regulation of cell-type specific interleukin-2 receptor α-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-κB family proteins. Mol. Cell. Biol. 15:1786-1796.
18. Leiden, J.M., C.-Y. Wang, B. Petryniak, D.M. Markovitz, G.J. Nabel, and C.B. Thompson. 1992. A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. J. Virol. 66:5890-5897.
19. Clark, N.M., M.J. Smith, J.M. Hilfinger, and D.M. Markovitz. 1993. Activation of the human T-cell leukemia virus type I enhancer is mediated by binding sites for Elf-1 and the pets factor. J. Virol. 67:5522-5528.
20. Mikaelian, I., and A. Sergeant. 1992. A general and fast method to generate multiple site directed mutations. Nucleic Acids Res. 20:376.
21. Evan, G.I., G.K. Lewis, G. Ramsay, and J.M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogenc product. Mol. Cell. Biol. 5:3610-3616.
22. Pollok, R., and R. Treisman. 1990. A sensitive method for the determination of protein-DNA binding specificities. Nucleic Acids Res. 18:6197-6204.
23. Marais, R.M., J.J. Hsuan, C. McGuigan, J. Wynne, and R. Treisman. 1992. Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. EMBO (Eur. Mol. Biol. Organ.) J. 11:97-105.
24. Nye, J.A., J.M. Petersen, C.V. Gunther, M.D. Jonsen, and B.J. Graves. 1992. Interaction of murine Ets-1 with GGA-binding sites establishes the ETS domain as a new DNA binding motif. Genes & Dev. 6:975-990.
25. Woods, D.B., J. Ghysdael, and M.J. Owen. 1992. Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 protein. Nucleic Acids Res. 20:699-704.
26. Urness, L.D., and C.S. Thummel. 1990. Molecular interactions within the ecydysone regulatory hierarchy: DNA binding properties ot the Drosophila ecydysone-inducible E74A protein. Cell. 63:47-61.
27. Mao, X., S. Miesfeldt, H. Yang, J.M. Leiden, and C.B. Thompson. 1994. The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. J. Biol Chem. 269:18216-18222.
28. Bosselut, R., J. Levin, E. Adjadj, and J. Ghysdael. 1993. A single ammo acid substitution in the Ets domain alters core DNA binding specificity of Ets2 to that of the related transcription factors Elf-1 and E74. Nucleic Acids Res. 21:5184-5191.
29. Altschul, S.F., W. Gish, W. Miller, E.W. Myers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
30. Treisman, R., R. Marais, and J. Wynne. 1992. Spatial flexibility in ternary complexes between SRF and its accessory proteins. EMBO (Eur. Mol. Biol. Organ.) J. 11:4631-4640.