Transgenic mice carrying the human β2-adrenergic receptor gene with its own promoter overexpress β2-adrenergic receptors in liver

European Journal of Biochemistry

Volumn 241, Issue 2, 1996, Pages 417-424

  André, Claudine ^a   Erraji, Loubna ^a   Gaston, Jesintha ^a   Grimber, Gisèle ^a   Briand, Pascale ^a   Guillet, Jean Gérard ^a  

^a INSERM   (France)

Author keywords

Human 2 adrenergic receptors; Liver; Transgenic mice

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; CYANOPINDOLOL I 125; ISOPRENALINE; MESSENGER RNA; PROPRANOLOL; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN; CONTROLLED STUDY; DEVELOPMENT; GENE EXPRESSION; HEART; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER; LOCOMOTION; LUNG; MOUSE; MUSCLE; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DENSITY; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ADENYLATE CYCLASE; ANIMALS; BASE SEQUENCE; DNA PROBES; FEMALE; GENE EXPRESSION; GTP-BINDING PROTEINS; HUMANS; IODOCYANOPINDOLOL; ISOPROTERENOL; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; PHENOTYPE; PINDOLOL; PROMOTER REGIONS (GENETICS); RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RNA, MESSENGER; TISSUE DISTRIBUTION;

ANIMALIA; MUS MUSCULUS;

EID: 0029961290     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.00417.x     Document Type: Article

References (38)

1. Engels, F., Carstairs, J. R., Barnes, P. J. & Nijkamp, F. P. (1989) Autoradiographic localization of changes in pulmonary β-adrenoceptors in an animal model of atopy, Eur. J. Pharmacol. 164. 139-146.
2. 2-adrenoceptor mRNAs by thyroid state in the heart, Endocrinology 129, 1116-1118.
3. Rao, G. S., Seidler, F. J. & Slotkin, T. A. (1995) Modulation of hepatic adrenoceptor ontogeny by thyroid hormone, Res. Commun. Mol. Pathol. Pharmacol. 87, 27-42.
4. Benschop, R. J., Nieuwenhuis, E. E. S., Tromp, E. A. M., Godaert, G. L. R., Ballieux, R. E. & van Doornen, L. J. P. (1994) Effects of ß-adrenergic blockade on immunologic and cardiovascular changes induced by mental stress, Circulation 89, 762-769.
5. Pandey, S. C., Ren, X., Sagen, J. & Pandey, G. N. (1995) β-Adrenergic receptor subtypes in stress-induced behavioral depression, Pharmacol. Biochem. Behav. 51, 339-344.
6. 2-adrenoceptors in different human heart diseases, Arch. Pharmacol. 343, 217-220.
7. Bohm, M. (1995) Alterations of β-adrenoceptor-G-protein-regulated adenylyl cyclase in heart failure, Mol. Cell. Biochem. 147, 147-160.
8. 2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease, J. Am. Coll. Cardiol. 14, 323-331.
9. Venter, J. G., Fraser, C. M. & Harrison, L. C. (1980) Autoantibodies to β-adrenergic receptors: a possible cause of adrenergic hyporesponsiveness in allergic rhinitis and asthma. Science 207, 1361-1363.
10. 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy, J. Clin. Invest. 86, 1658-1663.
11. Goin, C. G., Borda, E., Segovia, A. & Sterin-Borda, L. (1991) Distribution of antibodies against β-adrenoceptors in the course of human Trypanosoma cruzi infection, Proc. Soc. Exp. Biol. Med. 197, 186-192.
12. Rosenbaum, M. B., Chiale, P. A., Schejtman, D., Levin, M. & Elizari, M. (1994) Antibodies to β-adrenergic receptors disclosing agonist-like properties in idiopathic dilated cardiomyopathy and Chagas' heart disease, J. Cardiovasc. Electrophysiol. 5, 367-375.
13. 2-udrenergic receptors in patients with primary electrical cardiac abnormalities, J. Am. Coll. Cardiol. 26, 864-869.
14. 2-adrenergic receptor autoantibodies in asthma, Am. J. Resp. Cell. Mol. Biol. 12, 531 -539.
15. 1-adrenoceptors in transgenic mice, Cardiovasc. Res. 27, 1606-1612.
16. Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A. & Lefkowitz, R. J. (1994) Enhanced myocardial function in transgenic mice overexpressing the /y;-adrenergic receptor. Science 264, 582 -586.
17. Gaudin, C., Ishikawa, Y., Wight, D. C., Mahdavi, V., Nadal-Ginard, B., Wagner, T. E., Vatner, D. E. & Homey, C. J. (1995) Overexpression of Gsα protein in the hearts of transgenic mice, J. Clin. Invest. 95, 1676-1683.
18. Koch. W. J., Rockman, H. A., Samama, P., Hamilton, R. A.. Bond, R.-A., Milano, C. A. & Lefkowitz, R. J. (1995) Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a β-ARK inhibitor, Science 268, 1350-1353.
19. Emorine, L. J., Marullo, S., Delavier-Klutchko, C., Kaveri, S. Y. Durieu-Trautmann, O, & Strosberg, A. D. (1987) Structure of the gene for human β2-adrenergic receptor: expression and promoter characterization. Proc. Natl Acad. Sci. USA 84, 6995-6999.
20. 2-adrenergic receptor and their putative promoter regions, J. Biol. Chem. 262, 7321-7327.
21. 2-adrenergic receptor gene into Yl cells, EMBO J. 7, 133-138.
22. 2-adrenergic receptors in 3T3-L1 fibroblasts, Biochem. J. 260, 53-59.
23. Hogan, B. L. M., Constantini, F. & Lacy, E. (1986) Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
24. Chirgwin, J. M., Przybyla, A. E., McDonald, R. J. & Rutter, W. J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry 18. 5294-5299.
25. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular cloning: a laboratory manual, 2nd edn, Cold Spring Harbor Laboratory. Cold Spring Harbor NY.
26. Munson, P. J. & Rodbard, D. (1980) A versatile computerized approach for the characterization of ligand binding systems. Anal. Biochem. 107, 220-239.
27. McPherson, G. A. (1983) A practical computer-based approach to the analysis of radioligand binding experiments. Comput. Prog. Biomed. 17, 107-114.
28. 2-adrenoceptors in various human tissues. Life Sci. 52, 1063-1070.
29. 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. Mol. Pharmacol. 43, 343-348.
30. Graham, S. M., Herring, P. A. & Arinze, I. J. (1987) Age-associated alterations in hepatic β-adrenergic receptor/adenylate cyclase complex, Am. J. Physiol. 253, 277-282.
31. Dax, E. M., Partilla, J. S., Piñeyro, M. A. & Gregerman, R. I. (1987) β-Adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging. Endocrinology 120, 1534-1541.
32. Milligan, G., Shah, B. H., Mullaney, I. & Grassie, M. A. (1995) Biochemical approaches to examine the specificity of interactions between receptors and guanine nucleotide binding proteins, J. Recept. Signal Transduct. Res. 15, 253-265.
33. 2-adrenoceptor subtypes in various mouse tissues, Neurosci. Lett. 160, 96-100.
34. 125I]pindolol binding to human peripheral lung β-receptors, Biochem. Pharmacol. 36. 2557-2564.
35. Sharma, R. K. & Jeffery, P. K. (1990) Airway β-adrenoceptor number in cystic fibrosis and asthma, Clin. Sci. 78, 409-417.
36. Liggett, S. B., Shah, S. D. & Cryer, P. E. (1988) Characterization of β-adrenergic receptors of human skeletal muscle obtained by needle biopsy. Am. J. Physiol. 254, 795-798.
37. 2-adrenoceptor subpopulations in children with congenital heart disease, Eur. J. Pediatr. 150, 388-394.
38. 2-adrenoceptors in the failing and nonfailing human heart, Eur. J. Clin. Phurmacol. 42, 607-611.