Disaggregation of polyribosomes in the spinal anterior horn cells in a patient with X-linked spinal and bulbar muscular atrophy

Acta Neuropathologica

Volumn 91, Issue 4, 1996, Pages 444-447

  Oyanagi, Kiyomitsu ^a   Aoki, Kaoru ^b,d   Morita, Takashi ^c   Igarashi, Shuichi ^a   Inuzuka, Takashi ^a   Horikawa, Yoh ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b Shinrakuen Hospital   (Japan)

^c Sinrakuen Hospital   (Japan)

^d Nagaoka Nishi Hospital   (Japan)

Author keywords

Anterior horn cells; Kennedy Alter Sung syndrome; Ribosome; Rough endoplasmic reticulum; Spinal and bulbar muscular atrophy

Indexed keywords

ADULT; ANTERIOR HORN CELL; ARTICLE; CASE REPORT; ELECTRON MICROSCOPY; HEREDITARY SPINAL MUSCULAR ATROPHY; HUMAN; HUMAN TISSUE; MALE; NERVE CELL DEGENERATION; NISSL SUBSTANCE; POLYSOME; PRIORITY JOURNAL; ROUGH ENDOPLASMIC RETICULUM; SPINAL CORD VENTRAL HORN;

ANTERIOR HORN CELLS; ENDOPLASMIC RETICULUM, ROUGH; HUMANS; LINKAGE (GENETICS); MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; MUSCULAR ATROPHY, SPINAL; POLYRIBOSOMES; SPINAL CORD; X CHROMOSOME;

EID: 0029961055     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050450     Document Type: Article

References (17)

1. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD (1994) Molecular biology of the cell. 3rd edn. Garland. New York, pp 223-242
2. Doyu M, Sobue G, Mukai E, Kachi T, Yasuda T, Mitsuma T, Takahashi A (1992) Severity of X-linked recessive bulbospinal neuropathy correlates with size of the tandem CAG repeat in androgen receptor gene. Ann Neurol 32: 707-710
3. Ghadially FN (1988) Ultrastructural pathology of the celi and matrix, 3rd edn. Butterworths, London, pp 413-571
4. Hirano A (1982) Aspects of the ultrastructure of amyotrophic lateral sclerosis. In: Rowland LP (ed) Human motor neuron diseases. Raven Press, New York, pp 75-88
5. Igarashi S, Tanno Y, Onodera O, Yamazaki M, Sato S, Ishikawa A, Miyatani N, Nagashima M, Ishikawa Y, Sahashi K, Ibi T, Miyatake T, Tsuji S (1992) Strong correlation between the number of CAG repeats in androgen receptor genes and the clinical onset of features of spinal and bulbar muscular atrophy. Neurology 42: 2300-2302
6. Kennedy WR. Alter M, Sung JH (1968) Progressive proximal spinal and bulbar muscular atrophy of late onset, A sex-linked recessive trait. Neurology 18: 671-680
7. La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH (1991) Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352: 77-79
8. Magee KR (1960) Familial progressive bulbar-spinal muscular atrophy. Neurology 10: 295-305
9. Mukai E, Ishihara Y, Sobue G, Kaneshima H, Hirabayashi N (1981) One autopsy case of bulbar-spinal muscular atrophy in adult males. Clin Neurol (Tokyo) 21: 228-233
10. Nagashima T, Seko K, Hirose K, Mannen T, Yoshimura S, Arima R, Nagashima K, Morimatsu Y (1988) Familial bulbospinal muscular atrophy associated with testicular atrophy and sensory neuropathy (Kennedy-Alter-Sung syndrome). Autopsy case report of two brothers. J Neurol Sci 87: 141-152
11. Ogata A, Nagashima T, Nagashima K (1989) Central nervous system pathology of bulbospinal muscular atrophy. Neurol Med (Tokyo) 30: 16-23
12. Ogata A, Matsuura T, Tashiro K, Moriwaka F, Demura T, Koyanagi T, Nagashima K (1994) Expression of androgen receptor in X-linked spinal and bulbar muscular atrophy and amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 57: 1274-1275
13. Oyanagi K, Makifuchi T, Ikuta F (1983) A topographic and quantitative study of neurons in human spinal gray matter, with special reference to their changes in amyotrophic lateral sclerosis. Biomed Res 4: 211-224
14. Sar M, Stumpf WE (1977) Androgen concentration in motor neurons of cranial nerves and spinal cord. Science 197: 77-79
15. Sheridan PJ, Weaker FJ (1982) Androgen receptor systems in the brain stem of the primate. Brain Res 235: 225-232
16. Sobue G, Hashizume Y, Mukai E, Hirayama M, Mitsuma T, Takahashi A (1989) X-linked recessive bulbospinal neuropathy. A clinicopathological study. Brain 112: 209-232
17. Terao S, Sobue G, Takeda A, Mitsuma T, Takahashi A (1989) Loss of spinal anterior horn cells in X-linked recessive bulbospinal muscular atrophy. A morphometric study of lower motoneuron loss. Clin Neurol (Tokyo) 29: 1338-1344