Dexamethasone and cyclosporin A modulation of cytokine expression and specific antibody synthesis in an allergic bronchopulmonary aspergillosis murine model

European Journal of Clinical Investigation

Volumn 26, Issue 11, 1996, Pages 951-959

  Wang, J M ^a   Chu, H W ^a   Bosse M ^a   St Pierre, J ^a,b   Boutet, M ^a   Laviolette, M ^a  

^a LAVAL UNIVERSITY   (Canada)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Aspergillus fumigatus; Cytokines; Eosinophils; Immunohistochemistry; Western blotting

Indexed keywords

CYCLOSPORIN A; CYTOKINE; DEXAMETHASONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; INTERLEUKIN 4; INTERLEUKIN 5;

ALLERGIC DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; DRUG EFFECT; EOSINOPHILIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG ASPERGILLOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0029960703     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1996.1850575.x     Document Type: Article

References (30)

1. Hinson KFW, Moon AJ, Plummre NS. Bronchopulmonary aspergillosis: a review and report of eight new cases. Thorax 1952;7:317-33.
2. Katzenstein ALA, Sale SR, Greenberger PA. Allergic Aspergillus sinusitis: a newly recognized form of sinusitis. J Allergy Clin Immunol 1983;72:89-93.
3. Greenberger PA. Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 1984;74:645-53.
4. Laufer P, Fink JN, Bruns WT et al. Allergic bronchopulmonary aspergillosis in cystic fibrosis. J Allergy Clin Immunol 1984; 73:44-8.
5. Nelson LA, Callerame ML, Schwartz RH. Aspergillosis and atopy in cystic fibrosis. Am Rev Respir Dis 1979;120:863-73.
6. Zeaske RM, Bruns WT, Fink JN et al. Immune responses to aspergillus in cystic fibrosis. J Allergy Clin Immunol 1988;82:73-7.
7. Hutcheson PS, Rejent AJ, Slavin RG. Variability in immune parameters of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. J Allergy Clin Immunol 1991;88: 390-4.
8. Wang JM, Denis M, Fournier M, Laviolette M. Experimental allergic bronchopulmonary aspergillosis in the mouse: immunological and histological features. Scand J Immunol 1994;39:19-26.
9. Chu HW, Wang JM, Boutet M, Laviolette M. Immunohistochemical analysis of a murine model of pulmonary eosinophilia and elevated IgE (abstract). Am J Respir Critical Care Med 1994;149:A117.
10. Murali PS, Kumar A, Choi H, Bansal NK, Fink JN, Kurup VP. Aspergillus fumigatus antigen induced eosinophilia in mice is abrogated by anti-IL-5 antibody. J Leuk Biol 1993;53:264-7.
11. Wang JM, Denis M, Fournier M, Laviolette M, Cyclosporin A increases the pulmonary eosinophilia induced by inhaled aspergillus antigen in mice. Clin Exp Immunol 1993;93:323-30.
12. Britten K, Howarth PH, Roche WR. Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies. Biotech Histochem 1993;68:271-81.
13. Bogomoletz W. Avantages de la coloration par le rouge sirius de l'amyloïde et des éosinophiles. Arch Anat Cytol Path 1980;4: 250-3.
14. Laemmli VK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227: 680-5.
15. Walker C, Kaegi MK, Braun P, Blaser K, Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 1991;88:935-42.
16. Robinson D, Hamid Q, Ying S et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
17. Silberstein D, David J. The regulation of human eosinophil function by cytokines. Immunol Today 1987;8:380-5.
18. Lukacs NW, Stricter RM, Chensue SW, Kunkel SL. Interleukin-4-dependent pulmonary osinophil infiltration in a murine model of asthma. Am J Respir Cell Mol Biol 1994;10:526-32.
19. Bradding P, Feather IH, Wilson S et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol 1993;151: 3853-65.
20. Dent LA, Strath M, Mellor AL, Sanderson CJ. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med 1990;8:349-55.
21. Schleimer RP, Bochner BS. The effects of glucocorticoids on human eosinophils. J Allergy Clin Immunol 1994;94:1202-13.
22. Mosmann RL, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cells clone. I. Definition ccording to profiles of lymphokines activities and secreted proteins. J Immunol 1986;136:2348-57.
23. Chen S-S. Cyclosporine A acts as a potent co-stimulator in upregulation of IgE antibody synthesis and expression of Fc receptor for IgE-A unifying hypothesis of the cellular mechanisms of cyclosporine A. Transplant Proc 1988;20(2) Suppl. 2:92-102.
24. Klaus GGB, Kunkl A. Effects of cyclosporin on the immune system of the mouse. II. Cyclosporin inhibits the effector function of primary T helper cells, but not helper cell priming. Transplantation 1983;36:80-4.
25. Pereira GM, Miller JF, Shevach EM. Mechanism of action of cyclosporine A in vivo II. T cell priming in vivo to alloantigen can be mediated by an IL-2-independent cyclosporine A-resistant pathway. J Immunol 1990;144:2109-16.
26. Terada N, Or R, Weinberg K, Domenico J, Lucas JJ, Gelfand EW. Transcription of IL-2 and IL-4 genes is not inhibited by cyclosporin A in competent T cells. J Biol Chem 1992;267:21207-10.
27. Hudak SA, Gollnick SO, Conrad DH, Kehry MR. Murine B-cell stimulatory factor 1 (interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells. Proc Natl Acad Sci USA 1987;84:4606-10.
28. Ishizaka K. IgE-binding factors and regulation of the IgE antibody response. Annu Rev Immunol 1988;6:513-34.
29. Young MC, Leung DY, Geha RS. Production of IgE-potentiating factor in man by T cell lines bearing Fc receptors for IgE. Eur J Immunol 1984;14:871-8.
30. Chen S-S, Stanescu G, Magalski AE, Qian Y-Y. Cyclosporin A is an adjuvant in murine IgE antibody responses. J Immunol 1989;142:4225-32.