Neuropeptide Y in salivary glands of the rat: Origin, release and secretory effects

Regulatory Peptides

Volumn 61, Issue 2, 1996, Pages 125-134

  Ekstrom J ^a   Ekman, R ^a   Luts, A ^b   Sundler, F ^b   Tobin, G ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Neuropeptide Y; Neuropeptide Y release; Salivary gland innervation; Salivary protein and amylase release; Sensory denervation; Sympathetic and parasympathetic denervation

Indexed keywords

ADRENALIN; AMYLASE; ATROPINE; BETHANECHOL; CAPSAICIN; NEUROPEPTIDE Y; PHENTOLAMINE; PROPRANOLOL; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENERVATION; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INNERVATION; MALE; NERVE FIBER; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN SECRETION; RADIOIMMUNOASSAY; RAT; SALIVARY GLAND; SYMPATHECTOMY; VAGOTOMY;

EID: 0029960218     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-0115(95)00157-3     Document Type: Article

References (35)

1. Ekström, J., Månsson, B., Tobin, G., Garrett, J. R. and Thulin, A., Atropine-resistant secretion of parotid saliva on stimulation of the auriculo-temporal nerve in the rat, Acta Physiol. Scand., 119 (1983) 445-449.
2. Månsson, B. and Ekström, J., On the non-adrenergic, non-cholinergic contribution to the parasympathetic nerve-evoked secretion of parotid saliva in the rat, Acta Physiol. Scand., 141 (1991) 197-205.
3. Asztély, A., Tobin, G. and Ekström, J., Masticatory-salivary reflexes mobilize non-adrenergic, non-cholinergic secretory mechanisms in parotid glands of rats, Acta Physiol. Scand., 151 (1994) 373-376.
4. Ekström, J., Neuropeptides and secretion, J. Dent. Res., 66 (2) (1987) 524-530.
5. Lundberg, J. M., Martling, C.-R. and Hökfelt, T., Airways, oral cavity and salivary glands: classical transmitters and peptides in sensory and autonomie neurons. In Björklund, A., Hökfelt, T. and Owman, C. (Eds.) Handbook of Chemical Neuroanatomy, Elsevier, Amsterdam, 1988, pp. 391-444.
6. Leblanc, G. G. and Landis, S. C., Target specificity of neuropeptide Y- immunoreactive cranial parasympathetic neurons, J. Neurosci., 8 (1988) 146-155.
7. Sharkey, K. A., Mathison, R., Sharif, M. N. and Davison, J. S., The effects of streptozotocin-induced diabetes on the peptidergic innervation and function of the rat parotid gland, J. Auton. Nerv. Syst., 27 (1989) 127-138.
8. Alm, P. and Ekström, J., Cholinergic nerves of unknown origin in the parotid glands of rats, Archs. Oral. Biol., 21 (1976) 417-421.
9. Alm, P. and Ekström, J., On the adrenergic innervation of the rat parotid gland, Experientia, 33 (1977) 523-524.
10. Ekström, J., Ekman, R., Håkanson, R., Luts, A., Sundler, F. and Tobin, G., Effects of capsaicin pretreatment on neuropeptides and salivary secretion of rat parotid glands, Br. J. Pharmacol., 97 (1989) 1031-1038.
11. Jansen, I., Uddman, R., Ekman, R., Olesen, J. and Edwinsson, L., Distribution and effects of neuropeptide Y, vasoactive intestinal peptide, substance P and calcitonin gene related-peptide in human middle meningeal arteries: comparisons with cerebral and temporal arteries, Peptides, 13 (1992) 527-536.
12. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randal, R.J., Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
13. Hägele, E. O., Schaich, E., Rauscher, E., Lehmann, P., Bürk, H. and Wahlefeld, A.-W., Mechanism of action of human pancreatic and salivary α-amylase on α-4-nitrophenyl maltoheptaoside substrate, Clin. Chem., 28 (1982) 2201-2205.
14. Dunér-Engström, M., Larsson, O. and Fredholm, B.B., Continuous monitoring of potassiun efflux from rat parotid gland fragments by potassium selective electrodes, Acta Physiol. Scand., 126 (1986) 551-555.
15. Ekström, J., Brodin, E., Håkanson, R. and Sundler, F. Vasoactive intestinal polypeptide and substance P in salivary glands of the rat following denervation or duct ligation, Regul. Pept., 10 (1984) 1-10.
16. Schultz, T., Soinila, J., Tolonen, R., Häppölä, O., Uusitalo, H. and Salo, A., The sympathetic and parasympathetic nature of neuropeptide Y-immunoreactive nerve fibres in the major salivary glands of the rat, Histochem. J., 26 (1994) 563-570.
17. Ekström, J., Garre, J. R., Månsson, B. and Tobin, G., The effects of atropine and chronic sympathectomy on maximal parasympathetic stimulation of parotid saliva in rats, J. Physiol., 403 (1988) 105-116.
18. Alm, P., Asking, B., Emmelin, N. and Gjörstrup, P., Adrenergic nerves to the rat parotid gland originating in the contralateral sympathetic chain, J. Auton. Nerv. Syst., 11 (1984) 309-316.
19. Tobin, G., Ekström, J., Ekman, R. and Håkanson, R., Influence of atropine on the depletion of vasoactive intestinal peptide, substance P and calcitonin gene-related peptide from rat parotid gland in response to parasympathetic nerve stimulation, Acta Physiol. Scand., 150 (1994) 463-465.
20. Modin, A., Weitzberg, E. and Lundberg, J.M., Nitric oxide regulates peptide release from parasympathetic nerves and vascular reactivity to vasoactive intestinal polypeptide in vivo, Eur. J. Pharmacol., 261 (1994) 185-197.
21. Lundberg, J. M. and Tatemoto, K., Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to α-adrenoceptor resistant sympathetic vasoconstriction, Acta Physiol. Scand., 116 (1982) 393-402.
22. Nilsson, B.-O., Rosengren, E. and Ekström, J., Effects of stimulation of the parasympathetic and sympathetic innervation in bursts on the syntheses of polyamines, DNA and protein in salivary glands of the rat: non-adrenergic, non-cholinergic responses, Acta Physiol. Scand., 143 (1991) 161-168.
23. Ekström, J., Månsson, B. and Tobin, G., Relative secretory contributions of the three major salivary glands of the rat in response to substance P and supersensitivity, Arch. Oral. Biol., 28 (1983) 859-863.
24. Ekström, J., Månsson, B. and Tobin, G., Vasoactive intestinal peptide evoked secretion of fluid and protein from rat salivary glands, and the development of supersensitivity, Acta Physiol. Scand., 119 (1983) 169-175.
25. Sundler, F., Ekblad, E., Grunditz, T., Håkanson, R., Luts, A. and Uddman, R., NPY in peripheral non-adrenergic neurons. In Mutt, V. (Ed.), Neuropeptide Y, Raven Press, New York, 1989, pp. 93-102.
26. Cox, H.M., Cuthbert, A.W., Håkanson, R. and Wahlestedt, C., The effect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia, J. Physiol., 398 (1988) 65-80.
27. Holst, J.J., Orskov, C., Knuthsen, S., Sheikh, S. and Nielsen, O. V., On the regulatory functions of neuropeptide Y (NPY) with respect to vascular resistance and endocrine secretion in the pig pancreas, Acta Physiol. Scand., 136 (1989) 519-526.
28. Raufman, J.P. and Singh, L., Actions of peptide YY and neuropeptide Y on chief cells from guinea pig stomach, Am. J. Physiol., 260 (1991) G820-826.
29. Tantisira, M. H., Jodal, M. and Lundgren, O., On the mechanisms of the basal alkaline secretion in the rat ileum in vivo, Acta Physiol. Scand., 142 (1991) 291-300.
30. Mulholland, M. W., Lally, K. and Taborsky, G. J., Inhibition of rat pancreatric exocrine secretion by neuropeptide Y: studies in vivo and in vitro, Pancreas, 6 (1991) 433-440.
31. Webber, S. E., The effects of peptide histidine isoleucine and neuropeptide Y on mucus volume output from the ferret trachea, Br. J. Pharmacol., 95 (1988) 49-54.
32. Ekström, J., Månsson, B., Olgart, L. and Tobin, G. Non-adrenergic, non-cholinergic salivary secretion in the ferret, Q. J. Exp. Physiol., 73 (1988) 163-173.
33. Tobin, G., Luts, A., Sundler, F. and Ekström, J., Peptidergic innervation of the major salivary glands of the ferret, Peptides, 11 (1990) 863-867.
34. Hauser-Kronberger, C., Saira, A. and Hacker, G. W., Die peptiderge Innervation menschlicher Speicheldrüsen (Glandula parotis und submandibularis), HNO, 40 (1993) 429-436.
35. Grkovics, I. and Anderson, C. R., Calretinin-containing preganglionic nerve terminals in the rat superior cervical ganglion surround neurons projecting to the submandibular salivary gland, Brain Res., 684 (1995) 127-135.