Molecular rearrangement of the MLL gene in adult acute myeloid leukemia without cytogenetic evidence of 11q23 aberration

Cancer Genetics and Cytogenetics

Volumn 86, Issue 1, 1996, Pages 13-17

  Kwong, Y L ^a   Liang, R ^a   Chan, Vivian ^a   Chan, T K ^a  

^a QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DAUNORUBICIN; DNA; ETOPOSIDE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CHROMOSOME 11Q; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CYTOGENETICS; FEMALE; GENE FREQUENCY; GENE REARRANGEMENT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; REMISSION;

EID: 0029960138     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-4608(95)00166-2     Document Type: Article

References (23)

1. Cleary ML (1991): Oncogenic conversion of transcription factors by chromosomal translocations. Cell 66:619-622.
2. Second MIC Cooperative Study Group (1988): Morphologic, immunologic and cytogenetic (MIC) working classification of the acute myeloid leukaemias. Br J Haematol 68:487-494.
3. Cuneo A, Michaux JL, Ferrant A, Van Hove L, Bosly A, Stul M, Dal Cin P, Van den Berghe E, Cassiman JJ, Negrini M, Piva N, Castoldi G, Van Den Berghe H (1992): Correlation of cytogenetic patterns and clinicobiological features in adult acute myeloid leukemia expressing lymphoid markers. Blood 79:720-727.
4. Corral J, Forster A, Thompson S, Lampert F, Kaneko Y, Slater R, Kroes WG, van der School CE, Ludwig WD, Karpas A, Pocock C, Cotter F, Rabbitts TH (1993): Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocations. Proc Natl Acad Sci USA 90:8538-8542.
5. Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel Y, Harden A, Rubinelli P, Smithe SD, LeBeau MM, Rowley JD, Diaz MO (1991): Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 86:10735-10739.
6. Cimino G, Moir DT, Canaani O, Williams K, Grist WM, Katzav S, Cannizzaro L, Lange B, Nowell PC, Croce CM, Canaani E (1991): Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23) and t(11;19)(q23;p13) chromosome translocation. Cancer Res 51:6712-6714.
7. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E (1992): The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71:701-708.
8. Tkachuk DC, Kohler S, Cleary ML (1992): Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71:691-700.
9. Djabali M, Selleri L, Parry P, Bower M, Yound BD, Evans G (1992): A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukemias. Nature Genetics 2:113-118.
10. Rowley JD (1993): Rearrangements involving chromosome band 11q23 in acute leukemia. Semin Cancer Biol 4:377-385.
11. Caligiuri MA, Schichman SA, Strout MP, Mrózek K, Baer MR, Frankel SR, Barcos M, Herzig GP, Croce CM, Bloomfleld CD (1994): Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocation. Cancer Res 54:370-373.
12. Bower M, Parry P, Carter M, Lillington DM, Amess J, Lister TA, Evans G, Young BD (1994): Prevalence and clinical correlations of MLL gene rearrangements in AML-M4/5. Blood 84:3776-3780.
13. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1985): Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Group. Ann Intern Med 103:620-625.
14. Kwong YL, Tso SC, Wong KF, Tang KC, Chan TK (1995). Translocational rearrangement of 11q23 in acute monoblastic leukemia. Cancer Genet Cytogenet 82:71-79.
15. Morgan GJ, Cotter F, Katz FE, Ridge SA, Domer P, Korsmeyer S, Widemann LM (1992): Breakpoints at 11q23 in infant leukemias with the t(11;19)(q23;p13) are clustered. Blood 80: 2172-2175.
16. Chen CS, Sorensen PHB, Domer PH, Reaman GH, Korsmeyer SJ, Heerema NA, Hammond GD, Kersey JH (1993): Molecular rearrangements on chromosome 11q23 predominates in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 81:2386-2393.
17. Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, van der Poel SZ, Kaneko Y, Morgan R, Sandberg AV, Chaganti RSK, Larson RA, Le Beau MM, Diaz MO, Rowley JD (1993): Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 329:909-914.
18. Hunger SP, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn JL, Willman CL, Cleary ML (1993): HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities. Blood 12:3197-3203.
19. Cimino G, Lo Cocco F, Biondi A, Elia L, Luciano A, Croce CM, Masera G, Mandelli F, Canaani E (1993): ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. Blood 82:544-546.
20. Rubnitz JR, Link MP, Shuster JJ, Carroll AJ, Hakami N, Frankel LS, Pullen DJ, Cleary ML (1994): Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: A Pediatric Oncology Group Study. Blood 84:570-573.
21. Pui CH, Behm FG, Downing JR, Hancock ML, Shurtleff SA, Ribeiro RC, Head DR, Mahmoud HH, Sandlund JT, Furman WL, Roberts M, Grist WM, Raimondi SC (1994): 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J Clin Oncol 12:909-915.
22. Sorensen PHB, Chen CS, Smith FO, Arthur DC, Domer PH, Bernstein ID, Korsmeyer SJ, Hammond D, Kersey JH (1994): Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes. J Clin Invest 93:429-437.
23. Sixth International Workshop on Chromosomes in Leukemia: London, England, May 11-18, 1987 (1989): Selected papers. Cancer Genet Cytogenet 40:171-216.