The immunopharmacology of mild asthma

Journal of Allergy and Clinical Immunology

Volumn 98, Issue 5 SUPPL., 1996, Pages

  Holgate, Stephen T ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Allergic inflammation; Cytokines; Mast cell; Mild asthma

Indexed keywords

NEDOCROMIL SODIUM;

ASTHMA; CELL INFILTRATION; CONFERENCE PAPER; CORRELATION FUNCTION; DISEASE SEVERITY; DRUG EFFICACY; EOSINOPHIL; HUMAN; LYMPHOCYTE; MAST CELL; MUCUS SECRETION; PRIORITY JOURNAL;

ASTHMA; CYTOKINES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKINS; LYMPHOCYTE ACTIVATION; MAST CELLS; T-LYMPHOCYTES;

EID: 0029959384     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)70011-8     Document Type: Article

References (64)

1. Djukanovic R, Wilson JW, Lai CKW, Holgate ST. The safety aspects of fibreoptic bronchoscopy, bronchoalveolar lavage and endobronchial biopsy in asthma. Am Rev Respir Dis 1991;143:772-7.
2. Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchoprovocation. Am Rev Respir Dis 1989;139:806-17.
3. Djukanovic R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, et al. Quantitation of mast cells and cosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis 1990;142:863-71.
4. Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Ehander I, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-9.
5. Kay AB. Origin of type 2 helper T cells. New Engl J Med 1994;330:567-9.
6. Meyers DA, Postma DS, Panhuysen CIM, et al. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994;23:464-70.
7. McKenzie ANJ, Culpepper JA, de Waal Malefyt R, et al. Interleukin 13, a T cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sci USA 1993;90:3735-9.
8. Liu MC, Bleecker ER, Lichtenstein LM, et al. Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. Am Rev Respir Dir 1990;142:126-32.
9. De Monchy JGR, Kauffman HF, Venge P, et al. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985;131:373-6.
10. Gratziou C, Carroll M, Montefort S, Teran L, Howarth PH, Holgate ST. Inflammatory and T-cell profile of asthma airways 6 hours after local allergen provocation. Am J Respir Crit Care Med (in press).
11. Vichow J-C Jr., Walker C, Hofner D, Kortsik C, Wesner P, Matthys H, et al. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am J Respir Crit Care Med 1995;151:960-8.
12. Gratziou C, Carroll M, Walls A, Howarth PH, Holgate ST. Early changes in T-lymphocytes recovered by BAL following local allergen challenge of asthmatic airways. Am Rev Respir Dis 1992;145:1259-64.
13. H1-type (interleukin 2 and interferon-gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatics and normal control subjects. Am J Resp Cell Mol Biol (in press).
14. Robinson DS, Hamid Q, Ying S, et al. Predominant Th2-type bronchoalveolar lavage T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
15. Teran LM, Carroll M, Frew AJ, et al. Leukocyte recruitment following local endobronchial allergen challenge in asthma: its relationship to procedure and to airway interleukin-8 release. Am J Resp Crit Care Med (in press).
16. Montefort S, Gratziou C, Goulding D, et al. Bronchial biopsy evidence for leucocyte infiltration and upregulation of leucocyte endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airway. J Clin Invest 1994;93:1411-21.
17. Spinger TS. Adhesion receptors of the immune system. Nature 1990;346:425-34.
18. Manning AM, Anderson DC. Transcription factor NF-κB: an emerging regulator of inflammation. In: Bristol JA, editor. Annual reports in medicinal chemistry. San Diego: Academic Press, 1994:235-44.
19. Gordon JR, Galli SJ. Mast cells as a source of both preformed and immunologically inducible TNFα/cachectin. Nature 1990;246:274-6.
20. εR1: a mechanism for sustained action of mast cell derived TNFα during IgE-dependent biological responses. J Exp Med 1991;174:103-7.
21. Bradding P, Feather IH, Howarth PH, et al. Interleukin 4 is localized to and released by human mast cells. J Exp Med 1992;176:1381-6.
22. Bradding P, Feather IH, Wilson S, Bardin PG, Heusser CH, Holgate ST, et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects: the mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol 1993;151:3853-65.
23. Bradding P, Roberts JA, Britten KM, et al. Interleukin-4, -5, -6 and TNFα in normal and asthmatic airways: evidence for the human mast cell as an important source of these cytokines. Am J Respir Cell Mol Biol 1994;10:471-80.
24. Walsh LJ, Trinchieri G, Waldorf HA, Whittaker D, Murphy GF. Human dermal mast cells contain and release tumor necrosis factor α which induces leucocyte adhesion molecule-1. Proc Natl Acad Sci USA 1991;86:4220-4.
25. Galli SJ. New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab Invest 1990:62:5-33.
26. Djukanovic R, Bradding P, Feather IH, Montefort S, Howarth PH, Jones DB, et al. Increased expression of CD44 and LFA-1 in bronchial biopsies from mild asthmatic patients. Eur Respir J (in press).
27. Okayama Y, Hunt TC, Kassel O, Ashman LK, Church MK. Assessment of the anti-c-kit monoclonal antibody YB5.B8 in affinity magnetic enrichment of human lung mast cells. J Immunol Methods 1994;169:153-6.
28. ε-receptor cross-linking and the presence of stem cell factor. J Immuno1 1995;155:1796-808.
29. Jones CA, Williams KA, Finlay-Jones JJ, Hart PH. Interleukin-4 production by human amnion epithelial cells and regulation of its activity by glycosaminoglycan binding. Biol Reprod 1995;52:839-47.
30. Tunon de Lara MJ, Okayama Y, McEwen AR, Heusser CH, Church MK, Walls AF. Release and inactivation of interleukin-4 by mast cells. Ann NY Acad Sci 1994;725:50-5.
31. Bradding P, Okayama Y, Church MK, Holgate ST. Heterogeneity of human mast cells based on their cytokine content. J Immunol 1995;155:297-307.
32. Walls AF, He S, Teran L, Buckley MG, et al. Granulocyte recruitment by human mast cell tryptase. Int Arch Allergy Immunol (in press).
33. Cairns JA, Walls AF. Mast call tryptase is a mitogen for epithelial cells: stimulation of IL-8 production and ICAM-1 expression. J Immunol (in press).
34. Walls AF, He S, Teran L, Holgate ST. Mast cell proteases as mediators of vascular leakage and cell accumulation [abstract]. J Allergy Clin Immunol 1993;91:256.
35. Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. Mast cell chymase: a potent secretagogue for airway gland serous cells. J Immunol 1989;142:2450-6.
36. Edwards AM. Sodium cromoglycate (Intal) as an anti-inflammatory agent for the treatment of chronic asthma. Clin Exp Allergy 1994;24:612-23.
37. Bradding P, Mediwake R, Feather IH, Madden J, Church MK, Holgate ST, et al. TNFα is localized to nasal mucosal mast cells and is released in acute allergic rhinitis. Clin Exp Allergy 1995;25:406-15.
38. Bissonnette EY, Encisco JA, Befus AD. Inhibition of release of tumor necrosis factor alpha (TNFα) from mast cells by the anti-inflammatory drugs, sodium cromoglycate and nedocromil sodium. Clin Exp Immunol 1995;102:78-84.
39. Calhoun WJ, Jarjour NN, Gleich GJ, Schwartz LB, Busse WW. Effect of nedocromil pretreatment on the immediate and late response of the airway to segmental allergen challenge. J Allergy Clin Immunol 1996;98:S46-50.
40. Djukanovic R, Feather I, Gratziou C, et al. The effects of natural allergen exposure during the grass pollen season on airways inflammatory cells in asthma symptoms. Thorax (in press).
41. Cushley MJ, Tattersfield AE, Holgate ST. Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol 1983;15:161-5.
42. Phillips GD, Holgate ST. The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5′-monophosphate in non-atopic asthma. Am Rev Respir Dis 1989;139:463-9.
43. Phillips GD, Polosa R, Holgate ST. The effect of histamine H1-receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma. Clin Exp Allergy 1989;19:405-9.
44. Cushley MJ, Holgate ST. Adenosine induced bronchoconstriction in asthma: role of mast cell mediator release. J Allergy Clin Immunol 1985;75:272-8.
45. Phillips GD, Scott VL, Richards R, Holgate ST. Effect of nedocromil sodium and sodium cromoglycate against bronchoconstriction induced by inhaled adenosine 5′-monophosphate. Eur Respir J 1989;2:210-21.
46. Phillips GD, Ng WH, Church MK, Holgate ST. The response of plasma histamine to bronchoprovocation with methacholine, adenosine 5′monophosphate, and allergen in atopic non-asthmatic subjects. Am Rev Respir Dis 1990;141:9-13.
47. Polosa R, Ng WH, Crimi N, Vancheri C, Holgate ST, Church MK, et al. Immediate mediator changes in bronchoalveolar lavage fluid after local adenosine 5′-monophosphate (AMP) challenge of asthmatic airways. Am J Respir Crit Care Med 1995;151:624-9.
48. 2b receptors evoke interleukin-8 secretion in human mast cells: an enprofylline sensitive mechanism with implications for asthma. J Clin Invest (in press).
49. Doull IJM, Sandall D, Smith S, Schreiber J, O'Toole S, Freezer NJ, et al. The differential inhibitory effect of regular inhaled corticosteroids on airway responsiveness to adenosine 5′monophosphate, methacholine and bradykinin in symptomatic children with recurrent wheeze. J Allergy Clin Immunol (submitted).
50. Avital A, Springer C, Bar-Yishay E, Godfrey S. Adenosine, methacholine and exercise challenges in children with asthma or pediatric chronic obstructive pulmonary disease. Thorax 1995;50:511-6.
51. Heaney LG, Shields MD, Cadden IS, Stevenson EC, Taylor R, Ennis M. Non-bronchoscopic lavage of pediatric airways: evidence for ongoing airway inflammation in childhood asthma [abstract]. Clin Exp Allergy 1994;24:1991.
52. Djukanović R, Lai CWK, Wilson JW, et al. Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic non-asthmatics and healthy controls. Eur Respir J 1992;5:538-44.
53. Vrugt B, Djukanović R, Bron A, Aalbers R. New insights into the pathogenesis of severe corticosteroid-dependent asthma. J Allergy Clin Immunol 1996;98:S22-6.
54. Paré PD, Bai TR. The consequences of chronic allergic inflammation: the Altounyan Address. Thorax 1995;50:328-32.
55. James AL, Paré PD, Hogg JC. The mechanisms of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-6.
56. Zhang S, Mohammed Q, Burbidge A, Morland CM, Roche WR. Cell cultures from bronchial subepithelial myofibroblasts enhance eosinophil survival in vitro. J Pathol (in press).
57. Zhang S, Howarth PH, Roche WR. Cytokine production by cell cultures from bronchial subepithelial myofibroblasts. Eur Respir J (in press).
58. Park H-S, Hung K-S, Shute J, Jaffer Z, Roberts K, Holgate ST, et al. GM-CSF is the predominant cytokine which enables eosinophil survival in nasal polyp tissue cultures with allergen [abstract]. Am J Respir Crit Care Med 1995;151(Suppl):A240.
59. Redington AE, Madden J, Roche WR, Holgate ST, Howarth PH. Transforming growth factor beta levels in bronchoalveolar lavage fluid are increased in asthma [abstract]. J Allergy Clin Immunol 1995;95(Suppl):377.
60. Redington AE, Madden J, Frew AJ, Djukanović R, Roche WR, Holgate ST, et al. Basic fibroblast growth factor in asthma: immunolocalization in bronchial biopsies and measurement in bronchoalveolar lavage fluid at baseline and following local allergen challenge. Am J Respir Crit Care Med 1996;151:A702.
61. Redington AE, Springall DR, Ghatei MA, Bloom SR, Holgate ST, Polak JM, et al. Endothelin in bronchoalveolar lavage fluid and its relationship to airflow obstruction in asthma. Am Rev Respir Crit Care Med 1995;151:1034-9.
62. Redington AE, Springall DR, Ghatei MA, Frew AJ, Polak J, Holgate ST, et al. Airway endothelin release in asthma: influence of endobronchial allergen and corticosteroid therapy. Am J Respir Crit Care Med (in press).
63. Hudon C, Turcotte H, Boulet M, Laviolette M, Carrier G, Boulet L-P. Bronchial asthma with incomplete reversibility of airflow obstruction: a fibrotic disease. Am J Respir Crit Care Med (in press).
64. Frankel DJ, Bardin PG, Sanderson G, Lampe F, Johnson SL, Holgate ST. Lower airways inflammatory response during rhinovirus colds in normal and asthmatic subjects. Am J Respir Crit Care Med 1995;151:879-86.