Mammalian urea transporters

Current Opinion in Nephrology and Hypertension

Volumn 5, Issue 5, 1996, Pages 401-405

  Shayakul, Chairat ^a   Hediger, Matthias A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UREA;

ACTIVE TRANSPORT; HUMAN; KIDNEY MEDULLA; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSPORT AND BINDING PHENOMENA;

EID: 0029959290     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199609000-00004     Document Type: Review

References (21)

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7. Rousselet G, Ripoche P, Bailly P: Tandem sequence repeats in urea transporters: identification of a urea transporter signature sequence. Am J Physiol 1996, 270:F554-F555. Alignment of the UT2 and HUT11 amino-acid sequences revealed that the first halves of these proteins are weakly homologous to their second halves, thus providing preliminary evidence that urea transporters evolved by gene duplication.
8. Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, Knepper MA: Cellular and subcellular localization of the vasopressin-regulated urea transporter in rat kidney. Proc Natl Acad Sci USA 1996, 93:5495-5500. This study provides evidence that there is expression of the urea transporter proteins in both the apical membrane and subcellular vesicles of IMCD cells. This finding raises the possibility that the urea transporter is regulated by exocytosis.
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21. Bankir L, Kriz W: Adaptation of the kidney to protein intake and to urine concentrating activity: similar consequences in health and CRF. Kidney Int 1995, 47:7-24. This review highlights the role of urea transport in the adaptation of kidney to changes in protein intake and urinary concentrating activity, and the possible consequential effect of adaptation on the progression of renal disease.