Postmarathon paradox: Insulin resistance in the face of glycogen depletion

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 2 33-2, 1996, Pages

  Tuominen, Juha A ^a   Ebeling, Pertti ^b   Bourey, Raymond ^b   Koranyi, Laszlo ^b   Lamminen, Antti ^b   Rapola, Juhani ^b   Sane, Timo ^b   Vuorinen Markkola, Helena ^b   Koivisto, Veikko A ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NONE

Author keywords

exercise; glucose uptake; glycogen; glycogen synthase; insulin sensitivity; lipid metabolism

Indexed keywords

GLYCOGEN; GLYCOGEN SYNTHASE;

ADULT; ARTICLE; EXERCISE; GLYCOGEN METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; LIPID OXIDATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RUNNING; TASK PERFORMANCE;

EID: 0029958855     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.2.e336     Document Type: Article

References (31)

1. Ahlborg, G., P. Felig, L. Hagenfeldt, R. Hendler, and J. Wahren. Substrate turnover during prolonged exercise in man: splanchnic and leg metabolism of glucose, free fatty acids and amino acids. J. Clin. Invest. 53: 1080-1090, 1974.
2. 2 consumption. Metab. Clin. Exp. 40: 836-841, 1991.
3. Bergstrom, J., and E. Hultman. A study of the glycogen metabolism during exercise in man. Scand. J. Clin. Lab. Invest. 19: 218-228, 1967.
4. Coggan, A. R., W. M. Kohrt, R. J. Spina, D. M. Bier, and J. O. Holloszy. Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men. J. Appl. Physiol. 68: 990-996, 1990.
5. Danforth, W. H. Glycogen synthase activity in skeletal muscle: interconversion of two forms and control of glycogen synthesis. J. Biol Chem. 240: 588-593, 1965.
6. DeFronzo, R. A., J. D. Tobin, and R. Andres. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237 (Endocrinol. Metab. Gastrointest. Physiol. 6): E214-E223, 1979.
7. Devlin, J. T., and E. S. Horton. Metabolic fuel utilization during postexercise recovery. Am. J. Clin. Nutr. 49, Suppl. 5: 944-948, 1989.
8. Ebeling, P., R. Bourey, L. Koranyi, J. A. Tuominen, L. C. Groop, J. Henriksson, M. Mueckler, A. Sovijarvi, and V. A. Koivisto. Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity. J. Clin. Invest. 92: 1623-1631, 1993.
9. Ebeling, P., and V. A. Koivisto. Non-esterified fatty acids regulate lipid and glucose oxidation and glycogen synthesis in healthy man. Diabetologia 37: 202-209, 1994.
10. Erfle, J. D., and F. Sauer. The inhibitory effects of acyl-coenzyme A esters on the pyruvate and alpha-oxoglutarate dehydrogenase complexes. Biochim. Biophys. Acta 178: 441-452, 1969.
11. Ferrannini, E. The theoretical bases of indirect calorimetry: a review. Metab. Clin. Exp. 37: 287-301, 1988.
12. Flatt, J.-P. Use and storage of carbohydrate and fat. Am. J. Clin. Nutr. 61, Suppl. 1: 952S-959S, 1995.
13. Ivy, J. L. Muscle glycogen synthesis before and after exercise. Sports Med. 11: 6-19, 1991.
14. Ivy, J. L., B. A. Frishberg, S. W. Farrell, W. J. Miller, and W. M. Sherman. Effects of elevated and exercise-reduced muscle glycogen levels on insulin sensitivity. J. Appl. Physiol. 59: 154-159, 1985.
15. Kiechle, F. L., T. Malinski, and K. H. Moore. Insulin action: implications for the clinical laboratory. Lab. Med. 21: 565-573, 1990.
16. Kiens, B., and H. Lithell. Lipoprotein metabolism influenced by training-induced changes in human skeletal muscle. J. Clin. Invest. 83: 558-564, 1989.
17. Kiens, B., H. Lithell, K. J. Mikines, and E. A. Richter. Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. J. Clin. Invest. 84: 1124-1129, 1989.
18. Kirwan, J. P., R. C. Hickner, K. E. Yarasheski, W. M. Kohrt, B. V. Wiethop, and J. O. Holloszy. Eccentric exercise induces transient insulin resistance in healthy individuals. J. Appl. Physiol. 72: 2197-2202, 1992.
19. Koivisto, V. A. The physiology of marathon running. Sci. Prog. 70: 109-127, 1986.
20. Krzentowski, G., F. Pirnay, A. S. Luyckx, N. Pallikarakis, M. Lacroix, F. Mosora, and P. J. Lefebvre. Metabolic adaptations in post-exercise recovery. Clin. Physiol. 2: 277-288, 1982.
21. Lamminen, A. E., P. E. Hekali, E. Tiula, I. Suramo, and O.A. Korhola. Acute rhabdomyolysis: evaluation with magnetic resonance imaging compared with computed tomography and ultrasonography. Br. J. Radial. 62: 326-330, 1989.
22. Lash, J., M. Sherman, and S. Bloomfield. Muscle soreness: glucose and insulin response. Med. Sci. Sports Exercise Suppl. 19: 575, 1987.
23. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
24. Maggs, D. G., R. Jacob, F. Rife, R. Lange, P. Leone, M. J. During, W. V. Tamborlane, and R. J. Sherwin. Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadriceps muscle and adipose tissue. J. Clin. Invest. 96: 370-377, 1995.
25. Miles, J., R. Glasscock, J. Aikens, J. Gerich, and M. Haymond. A microfluorometric method for the determination of free fatty acids in plasma. J. Lipid Res. 24: 96-99, 1983.
26. O'Brien, M. J., C. A. Viguie, R. S. Mazzeo, and G. A. Brooks. Carbohydrate dependence during marathon running. Med. Sci. Sports Exercise 25: 1009-1017, 1993.
27. Randle, P. J., P. B. Garland, C. N. Hales, and E. A. Newsholme. The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 786-789, 1963.
28. Sherman, W. M., D. L. Costill, W. J. Fink, F. C. Hagerman, L. E. Armstrong, and T. F. Murray. Effect of a 42.2-km footrace and subsequent rest or exercise on muscle glycogen and enzymes. J. Appl. Physiol. 55: 1219-1224, 1983.
29. Stein, T. P., R. W. Hoyt, M. O. Toole, M. J. Leskiw, M. D. Schluter, R. R. Wolfe, and W. D. Hiller. Protein and energy metabolism during prolonged exercise in trained athletes. Int. J. Sports. Med. 10: 311-316, 1989.
30. Walker, M., B. G. Cooper, C. Elliott, J. W. Reed, H. Orskov, and K. G. Alberti. Role of plasma non-esterified fatty acids during and after exercise. Clin. Sci. Lond. 81: 319-325, 1991.
31. Winder, W. W., J. Arogyasami, R. J. Barton, I. M. Elayan, and P. R. Vehrs. Muscle malonyl-CoA decreases during exercise. J. Appl. Physiol. 67: 2230-2233, 1989.