Ligands for orphan receptors?

Journal of Endocrinology

Volumn 150, Issue SUPPL., 1996, Pages

  Soontjens, C D ^a   Rafter, J J ^a   Gustafsson, J A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; STEROID RECEPTOR;

CONFERENCE PAPER; GENE EXPRESSION REGULATION; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; CELLS; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; FATTY ACIDS, NONESTERIFIED; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LIGANDS; MICE; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0029958429     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (188)

1. Allan GF, Leng X, Tsai SY, Weigel NL, Edwards DP, Tsai M-J & O'Malley BW 1992a Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. Journal of Biological Chemistry 267 19513-19520
2. Allan GF, Tsai SY, Tsai M-J & O'Malley BW 1992b Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding. Proceedings of the National Academy of Sciences of the USA 89 11750-11754.
3. Apfel R, Benbrook D, Lernhardt E, Ortiz MA, Salbert G & Pfahl M 1994 A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Molecular and Cellular Biology 14 7025-7035.
4. Aronica SM & Katzenellenbogen BS 1993 Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen cyclic adenosine monophosphate and insulin-like growth factor-I. Molecular Endocrinology 7 743-752
5. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housinan DE & Evans RM 1987 Cloning of the mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor Science 237 268-275.
6. Axelson M & Sahlberg B-L 1983 Group separation and gas chromatography-mass spectrometry of conjugated steroids in plasma Journal of Steroid Biochemistry 18 313-321.
7. Baes M, Gulick T, Choi HS, Martinoli MG, Simha D & Moore DD 1994 A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Molecular and Cellular Biology 14 1544-1551.
8. Bagchi MK, Tsai SY, Tsai M-J & O'Malley BW 1992 Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro Proceedings of the National Academy of Sciences of the USA 89 2664-2668.
9. Baniahmad A, Kohne AC & Renkawitz R 1992a A transferable silencing domain is present in the thyroid hormone receptor in the v-erbA oncogene product and in the retinoic acid receptor. EMBO Journal 11 1015-1023.
10. Baniahmad A, Tsai SY, O'Malley BW & Tsai MJ 1992b Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses Proceedings of the National Academy of Sciences of the USA 89 10633-10637.
11. Banner CD, Goos-Nilsson A, Sjövall J, Gustafsson J-Å & Rafter JJ 1992 A method for characterisation of endogenous ligands to orphan receptors belonging to the steroid hormone receptor superfamily - isolation of progesterone from pregnancy plasma using progesterone receptor ligand-binding domain. Analytical Biochemistry 200 163-170.
12. Bardot O, Aldridge TC, Latruffe N & Green S 1993 PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochemical and Biophysical Research Communications 192 37-45.
13. Beato M 1989 Gene regulation by steroid hormones. Cell 56 335-344.
14. Becker-André M, André E & Delamarter JF 1993 Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. Biochemical and Biophysical Research Communications 194 1371-1379.
15. Becker-André M, Wiesenberg I, Schaeren-Wiemers N, André E, Missbach M, Saurat JH & Carlberg C 1994 Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. Journal of Biological Chemistry 269 28531-28534.
16. Beekman JM, Allan GF, Tsai SY, Tsai M-J & O'Malley BW 1993 Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Molecular Endocrinology 7 1266-1274.
17. Benbrook D & Pfahl M 1987 A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library. Science 238 788-791.
18. Bocos C, Göttlicher M, Gearing K, Banner C, Enmark E, Teboul M, Crickmore A & Gustafsson J-Å 1995 Fatty acid activation of peroxisome proliferator activated receptor (PPAR). Journal of Steroid Biochemistry and Molecular Biology 53 1-6.
19. Bocquel MT, Kumar V, Stricker C, Chambon P & Gronemeyer H 1989 The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor- and cell-specific. Nucleic Acids Research 17 2581-2595.
20. Bogazzi F, Hudson LD & Nikodem VM 1994 A novel heterodimerization partner for thyroid hormone receptor: Peroxisome proliferator-activated receptor. Journal of Biological Chemistry 269 11683-11686.
21. Boie Y, Adam M, Rushmore T & Kennedy BP 1993 Enantiomeric activation of the peroxisome proliferator-activated receptor. Journal of Biological Chemistry 268 5530-5534.
22. Braissant O, Foufelle F, Scotto C, Dauöa M & Wahli W 1996 Differential expression of peroxisome proliferator-activated receptors: tissue distribution of PPARα β and γ in the adult rat. Endocrinology 137 354-366.
23. Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF & Becker-André M 1994 RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Molecular Endocrinology 8 757-770.
24. Castelein H, Gulick T, Declercq PE, Mannaerts GP, Moore DD & Bats MI 1994 The peroxisome proliferator activated receptor regulates malic enzyme gene expression. Journal of Biological Chemistry 69 26754-26758.
25. Chambraud B, Berry M, Redeuilh G, Chambon P & Baulieu EE 1990 Several regions of human estrogen receptor are involved in formation of receptor-heat shock protein 90 complexes Journal of Biological Chemistry 265 20686-20691
26. Chang CS, Kokontis J & Liao SS 1988 Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. Proceedings of the National Academy of Sciences of the USA 85 7211-7215.
27. Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H & Chang Y 1989a Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. Biochemical and Biophysical Research Communications 165 735-741.
28. Chang C, Kokontis J, Liao SS & Chang Y 19896 Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. Journal of Steroid Biochemistry 34 391-395.
29. Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S & Burbach JP 1994 Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proceedings of the National Academy of Sciences of the USA 91 6040-6044.
30. Chen F, Cooney AJ, Wang Y, Law SW & O'Malley BW 1994 Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Molecular Endocrinology 8 1434-1444.
31. Conneely OM, Maxwell BL, Toft DO, Schrader WT & O'Malley BW 1987 The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. Biochemical and Biophysical Research Communications 149 493-501.
32. Cooney AJ, Tsai SY, O'Malley BW & Tsai M-J 1992 Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements allowing COUP-TF to repress hormonal induction of the vitamin D3 thyroid hormone and retinoic acid receptors. Molecular and Cellular Biology 12 4153-4163.
33. Cooney AJ, Leng X, Tsai SY, O'Malley BW & Tsai MJ 1993 Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D thyroid hormone and retinoic acid receptors. Journal of Biological Chemistry 268 4152-4160.
34. Dalman FC, Koenig RJ, Perdew GH, Massa E & Pratt WB 1990 In contrast to the glucocorticoid receptor the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90 Journal of Biological Chemistry 265 3615-3618.
35. Dalman FC, Sturzenbecker LJ, Levin AA, Lucas DA, Perdew GH, Petkovitch M, Chambon P, Grippo JF & Pratt WB 1991 Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form 'docking' complexes with hsp90. Biochemistry 30 5605-5608.
36. Danim K, Thompson CC & Evans RM 1989 Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 339 593-597.
37. Denis M, Wikström AC & Gustafsson J-Å 1987 The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90 000 non-hormone-binding protein. Journal of Biological Chemistry 262 11803-11806.
38. Denis M, Poellinger L, Wikström AC & Gustafsson J-Å 1988 Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state. Nature 333 686-688.
39. Denner LA, Schrader WT, O'Mallev BW & Weigel NL 1990 Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites. Journal of Biological Chemistry 265 16548-16555
40. Denner LA, Weigel NL, Maxwell BL, Schrader WT & O'Malley BW 1990 Regulation of progesterone receptor-mediated transcription by phosphorylation. Science 250 1740-1743.
41. Desvergne B & Wahli W 1995 PPAR a key nuclear factor in nutrient/gene interactions? In Inducible Transcription vol 1, pp 142-76. Ed P Bauerle. Boston/Basel/Berlin Birkhäuser
42. Dreyer C, Krey G, Keller H, Givel F, Helftenbein G & Wahli W 1992 Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68 879-887.
43. Ellinger-Ziegelbauer H, Hihi AK, Laudet V, Keller H, Wahli W & Dreyer C 1994 FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis. Molecular and Cellular Biology 14 2786-2797.
44. Enmark E, Kainu T, Pelto-Huikko M & Gustafsson J-Å 1994 Identification of a novel member of the nuclear receptor superfamily which is closely related to Rev-ErbA Biochemical and Biophysical Research Communications 204 49-56.
45. Evans RM 1988 The steroid thyroid hormone receptor superfamily. Science 240 889-895.
46. Fawell SE, Lees JA, White R & Parker MG 1990 Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell 60 953-962
47. Feigl G, Gram M & Pongs O 1989 A member of the steroid hormone receptor gene family is expressed in the 20-OH-ecdysone inducible puff 75B in Drosophila melanogaster. Nucleic Acids Research 17 7167-7178.
48. Forman BM & Samuels HH 1990 Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Molecular Endocrinology 4 1293-1301.
49. Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, McMorris T, Lamph WW, Evans RM & Weinberger C 1995 Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81 687-693.
50. Freedman LP 1992 Anatomy of the steroid receptor zinc finger region. Endocrine Reviews 13 129-145.
51. Gearing KL, Göttlicher M, Teboul M, Widmark E & Gustafsson J-Å 1993 Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proceedings of the National Academy of Sciences of the USA 90 1440-1444.
52. Gearing KL, Göttlicher M, Widmark E, Banner C, Tollet P, Strömstedt M, Rafter JJ, Berge RK & Gustafsson J-Å 1994 Fatty acid activation of the peroxisome proliferator activated receptor, a member of the nuclear receptor gene superfamily. Journal of Nutrition 124 1284S-1288S
53. Giguère V, Hollenberg SM, Rosenfeld MG & Evans RM 1986 Functional domains of the human glucocorticoid receptor. Cell 46 645-652.
54. Giguère V, Ong ES, Segui P & Evans RM 1987 Identification of a receptor for the morphogen retinoic acid. Nature 330 624-629.
55. Giguère V, Yang N, Segui P & Evans RM 1988 Identification of a new class of steroid hormone receptors. Nature 331 91-94.
56. Giguère V, Tini M, Flock G, Ong E, Evans RM & Otulakowski G 1994 Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. Genes and Development 8 538-553.
57. Godowski PJ, Picard D & Yamamoto KR 1988 Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins. Science 241 812-816.
58. Gottlicher M, Widmark E, Li Q & Gustafsson J-Å 1992 Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proceedings of the National Academy of Sciences of the USA 89 4653-4657.
59. Göttlicher M, Demoz A, Svensson D, Tollet P, Berge RK & Gustafsson J-Å 1993 Structural and metabolic requirements for activators of the peroxisome proliferator-activated receptor. Biochemical Pharmacology 46 2177-2184.
60. Graupner G, Wills KN, Tzukerman M, Zhang XK & Pfahl M 1989 Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity. Nature 340 653-656.
61. Green S & Chambon P 1987 Oestradiol induction of a glucocorticoid-responsive gene by a chimeric receptor. Nature 325 75-78
62. Grimaldi PA, Knobel SM, Whitesell RR & Abumrad NA 1992 Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Proceedings of the National Academy of Sciences of the USA 89 10930-10934.
63. Gronemeyer H 1992 Control of transcriptional activation by steroid hormone receptors. FASEB Journal 6 2524-2529.
64. Guarnieri C, Flamigni F & Caldarera CM 1980 A possible role of rabbit heart cytosol tocopherol binding in the transfer of tocopherol into nuclei Biochemical Journal 190 469-471.
65. Guiochon-Mantel A, Loosfelt H, Lescop P, Sar S, Atger M, Perrot-Applanat M & Milgrom E 1989 Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers. Cell 57 1147-1154.
66. Gulick T, Cresci S, Caira T, Moore DD & Kelly DP 1994 The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression Proceedings of the National Academy of Sciences of the USA 91 11012-11016.
67. Ham J & Parker MG 1989 Regulation of gene expression by nuclear hormone receptors. Current Opinion in Cell Biology 1 503-511.
68. Hamada K, Gleason SL, Levi B-Z, Hirschfeld S, Appella E & Ozato K 1989 H-2RIIBP a member of the nuclear hormone receptor superfamily that binds both to the regulatory element of major histocompatability class I genes and the estrogen response element. Proceedings of the National Academy of Sciences of the USA 86 8289-8293.
69. Hazel TG, Nathans D & Lau LF 1988 A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proceedings of the National Academy of Sciences of the USA 85 8444-8448.
70. Hazel TG, Misra R, Davis IJ, Greenberg ME & Lau LF 1991 Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Molecular and Cellular Biology 11 3239-3246.
71. + the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochemical and Biophysical Research Communications 205 1976-1983.
72. Hollenberg SM & Evans RM 1988 Multiple and cooperative transactivation domains of the human glucocorticoid receptor. Cell 55 899-906.
73. Honda S, Morohashi K, Nomura M, Takeya H, Kitajima M & Omura T 1993 Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. Journal of Biological Chemistry 268 7494-7502.
74. Huang Q, Alvares K, Chu R, Bradfield CA & Reddy JK 1994 Association of peroxisome proliferator-activated receptor and Hsp72. Journal of Biological Chemistry 269 8493-8497.
75. Ignar-Trowbridge DM, Nelson KG, Bidwell MC, Curtis SW, Washburn TF, McLachlan JA & Korach KS 1992 Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. Proceedings of the National Academy of Sciences of the USA 89 4658-4662.
76. Ignar-Trowbridge DM, Teng CT, Ross KA, Parker MG, Korach KS & McLachlan JA 1993 Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element. Molecular Endocrinology 7 992-998.
77. Issemann I & Green S 1990 Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347 645-650.
78. Issemann I, Prince RA, Tugwood JD & Green S 1993 The peroxisome proliferator-activated receptor retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. Journal of Molecular Endocrinology 11 37-47.
79. Joab I, Radanyi C, Renoir M, Buchou T, Catelli MG, Binart N, Mester J & Baulieu EE 1984 Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones. Nature 308 850-853.
80. Kastner P, Krust A, Mendelsohn C, Garnier JM, Zelent A, Leroy P, Staub A & Chambon P 1990 Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. Proceedings of the National Academy of Sciences of the USA 87 2700-2704.
81. Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K & Wahli W 1993 Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proceedings of the National Academy of Sciences of the USA 90 2160-2164.
82. Keller H, Givel F, Perroud M & Wahli W 1995 Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Molecular Endocrinology 9 794-804.
83. Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA & Evans RM 1992a Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proceedings of the National Academy of Sciences of the USA 89 1448-1452.
84. Kliewer SA, Umesono K, Noonan DJ, Heyman RA & Evans RM 1992b Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358 771-774.
85. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K & Evans RM 1994 Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proceedings of the National Academy of Sciences of the USA 91 7355-7359.
86. Koelle MR, Talbot WS, Segraves WA, Bender MT, Cherbas P & Hogness DS 1991 The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67 59-77.
87. Koelle MR, Segraves WA & Hogness DS 1992 DHR3: A Drosophila steroid receptor homolog. Proceedings of the National Academy of Sciences of the USA 89 6167-6171.
88. Koenig RJ, Warne RL, Brent GA, Harney JW, Larsen PR & Moore DD 1988 Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proceedings of the National Academy of Sciences of the USA 85 5031-5035.
89. Kost SL, Smith DF, Sullivan WP, Welch WJ & Toft DO 1989 Binding of heat shock proteins to the avian progesterone receptor. Molecular and Cellular Biology 9 3829-3838.
90. Kumar V, Green S, Stack G, Berry M, Jin JR & Chambon P 1987 Functional domains of the human estrogen receptor Cell 51 941-951.
91. Ladias JAA & Karathanasis SK 1991 Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251 561-565.
92. Lala DS, Rice DA & Parker KL 1992 Steroidogenic factor I a key regulator of steroidogenic enzyme expression is the mouse homolog of fushi tarazu-factor I. Molecular Endocrinology 6 1249-1258.
93. Lau LF & Nathans D 1985 Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO Journal 4 3145-3151.
94. Lau LF & Nathans D 1987 Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells, coordinate regulation with c-fos or c-myc. Proceedings of the National Academy of Sciences of the USA 84 1182-1186.
95. Lavorgna G, Ueda H, Clos J & Wu C 1991 FTZ-F1 a steroid hormone receptor-like protein implicated in the activation of fushi tarazu. Science 252 848-851
96. Law SW, Conneely OM, DeMayo FJ & O'Malley BW 1992 Identification of a new brain-specific transcription factor NURR1. Molecular Endocrinology 6 2129-2135.
97. Lazar MA, Hodin RA, Darling DS & Chin WW 1989 A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Molecular and Cellular Biology 9 1128-1136.
98. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H & Gonzalez FJ 1995 Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Molecular and Cellular Biology 15 3012-3022.
99. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM & Kliewer SA 1995 An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). Journal of Biological Chemistry 270 12953-12956.
100. Leng X, Tsai SY, O'Malley BW & Tsai M-J 1993 Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoic X receptor. Journal of Steroid Biochemistry and Molecular Biology 46 643-661.
101. Leroy P, Krust A, Zelent A, Mendelsohn C, Garnier JM, Kastner P, Dierich A & Chambon P 1991 Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO Journal 10 59-69.
102. Levin AA, Sturzenbecker LJ, Kazmer S, Bosakowski T, Huselton C, Allenby G, Speck J, Kratzeisen C, Rosenberger M, Lovey A & Grippo JF 1992 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha. Nature 355 359-361.
103. Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS & Wilson EM 1988 Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 340 327-330.
104. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR & Sigler PB 1991 Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352 497-505.
105. Luo X, Ikeda Y & Parker KL 1994 A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77 481-490.
106. McDonnell DP, Mangelsdorf DJ, Pike WJ, Haussler MR & O'Malley BW 1987 Molecular cloning of complementary DNA encoding the avian receptor for vitamin D Science 235 1214-1217.
107. Mangelsdorf DJ, Ong ES, Dyck JA & Evans RM 1990 Nuclear receptor that identifies a novel retinoic acid pathway. Nature 345 224-229.
108. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A & Evans RM 1992 Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes and Development 6 329-344.
109. Mendel DB, Bodwell JE, Gametchu B, Harrison RW & Munck A 1986 Molybdate-stabilized nonactivated glucocorticoid-receptor complexes contain a 90-kDa non-steroid-binding phosphoprotein that is lost on activation. Journal of Biological Chemistry 261 3758-3763.
110. Milbrandt J 1988 Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1 183-188.
111. Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K & Yamamoto T 1988 Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Research 16 11057-11074.
112. Miyajima N, Horiuchi R, Shibuya Y, Fukushige S & Matsubara K 1989 Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57 31-39.
113. Mlodzik M, Hiromi Y, Weber U, Goodman CS & Rubin GM 1990 The Drosophila seven-up gene a member of the steroid receptor gene superfamily controls photoreceptor cell fates. Cell 60 211-224.
114. Moore DD 1990 Diversity and unity in the nuclear hormone receptors: a terpenoid receptor superfamily. New Biologist 2 100-105.
115. Muerhoff AS, Griffin KJ & Johnson EF 1992 The peroxisome proliferator-activated receptor mediates the induction of CYP4A6 a cytochrome P450 fatty acid omega-hydroxylase by clofibric acid. Journal of Biological Chemistry 267 19051-19053
116. Muller WE, Maidhof A, Zahn RK, Schroder HC, Gasic MJ, Heidemann D, Bernd A, Kurelec B, Eich E & Seibert G 1985 Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo. Cancer Research 45 4822-4826.
117. Muller WE, Sobel C, Sachsse W, Diehl-Seifert B, Zahn RK, Eich E, Kljajic Z & Schroder HC 1986 Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes. European Journal of Cancer and Clinical Oncology 22 473-476.
118. Nakai A, Kartha S, Sakurai A, Toback FG & DeGroot LJ 1990 A human early response gene homologous to murine nur77 and rat NGFI-B and related to the nuclear receptor superfamily. Molecular Endocrinology 4 1438-1443.
119. Nathans D, Lau LF, Christy B, Hartzell S, Nakabeppu Y & Ryder K 1988 Genomic response to growth factors. Cold Spring Harbor Symposia on Quantitative Biology 53 893-900.
120. Nauber U, Pankratz MJ, Kienlin A, Seifert E, Klemm U & Jackle H 1988 Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps. Nature 336 489-492.
121. Nestel PJ 1990 Effects of n-3 fatty acids on lipid metabolism. Annual Review of Nutrition 10 149-167.
122. Ohkura N, Hijikuro M, Yamamoto A & Miki K 1994 Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochemical and Biophysical Research Communications 205 1959-1965.
123. O'Malley B 1990 The steroid receptor superfamily more excitement predicted for the future. Molecular Endocrinology 4 363-369.
124. Oro AE, Ong ES, Margolis JS, Posakony JW, McKeown M & Evans RM 1988 The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. Nature 336 493-496.
125. Palli SR, Hiruma K & Riddiford LM 1992 An ecdysteroid-inducible Manduca gene similar to the Drosophila DHR3 gene a member of the steroid hormone receptor superfamily Developmental Biology 150 306-318.
126. Patnaik RN & Nair PP 1977 Studies on the binding of d-α-tocopherol to rat liver nuclei. Archives of Biochemistry and Biophysics 178 333-341.
127. Petkovich M, Brand NJ, Krust A & Chambon P 1987 A human retinoic cid receptor which belongs to the family of nuclear receptors. Nature 330 444-450.
128. Picard D & Yamamoto KR 1987 Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor EMBO Journal 6 3333-3340.
129. Pignoni F, Baldarelli RM, Steingrimsson E, Diaz RJ, Patapoutian A, Merriam JR & Lengyel JA 1990 The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell 62 151-163.
130. Poletti A & Weigel NL 1993 Identification of a hormone-dependent phosphorylation site adjacent to the DNA-binding domain of the chicken progesterone receptor. Molecular Endocrinology 7 241-246.
131. Power RF, Lydon JP, Conneely OM & O'Malley BW 1991a Dopamine activation of an orphan of the steroid receptor superfamily Science 252 1546-1548.
132. Power RF, Mani SK, Codina J, Conneely OM & O'Malley BW 1991b Dopaminergic and ligand-independent activation of steroid hormone receptors Science 254 1636-1639
133. Pratt WB 1987 Transformation of glucocorticoid and progesterone receptors to the DNA-binding state. Journal of Cellular Biochemistry 35 51-68
134. Pratt WB, Jolly DJ, Pratt DV, Hollenberg SM, Giguère V, Cadepond FM, Schweizer-Groyer G, Catelli MG, Evans RM & Bauheu EE 1988 A region in the steroid binding domain determines formation of the non-DNA-binding 9 S glucocorticoid receptor complex. Journal of Biological Chemistry 263 267-273.
135. Qiu Y, Cooney AJ, Kuratam S, DeMayo FJ, Tsai SY & Tsai M-J 1994 Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proceedings of the National Academy of Sciences of the USA 91 4451-4455.
136. Reichel RR & Jacob ST 1993 Control of gene expression by lipophilic hormones FASEB Journal 7 427-436.
137. Ritchie HH, Wang LH, Tsai S, O'Malley BW & Tsai MJ 1990 COUP-TF gene: a structure unique for the steroid/thyroid receptor superfamily. Nucleic Acids Research 18 6857-6862
138. Rodriguez JC, Gil-Gomez G, Hegardt FG & Haro D 1994 Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. Journal of Biological Chemistry 269 18767-18772.
139. Rothe M, Nauber U & Jackle H 1989 Three hormone receptor-like Drosophila genes encode an identical DNA-binding finger. EMBO Journal 8 3087-3094.
140. Ryseck RP, Macdonald-Bravo H, Mattei MG, Ruppert S & Bravo R 1989 Structure mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO Journal 8 3327-3335.
141. Sanchez ER 1990 Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes. Journal of Biological Chemistry 265 22067-22070.
142. Sanchez ER, Faber LE, Henzel WJ & Pratt WB 1990 The 56-59 kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70 and 90 kilodalton heat shock proteins. Biochemistry 29 5145-5152.
143. Sap J, Munoz A, Damm KL, Goldberg Y, Ghysdael J, Leutz A, Beug H & Vennstrom B 1986 The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 324 635-640.
144. Sap J, Munoz A, Schmitt J, Stunnenberg H & Vennström B 1989 Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature 340 242-244.
145. Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D & Rodan GA 1992 Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Molecular Endocrinology 6 1634-1641.
146. Segraves WA & Hogness DS 1990 The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily. Genes and Development 4 204-219.
147. Sengupta P, Colbert HA & Bargmann CI 1994 The Celegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily. Cell 79 971-980
148. Sher T, Yi HF, McBride OW & Gonzalez FJ 1993 cDNA cloning chromosomal mapping and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32 5598-5604.
149. Sheridan PL, Evans RM & Horwitz KB 1989 Phosphotryptic peptide analysis of human progesterone receptor: New phosphorylated sites formed in nuclei after hormone treatment. Journal of Biological Chemistry 264 6520-6528.
150. Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA & Schmidt A 1994 NER a new member of the gene family encoding the human steroid hormone nuclear receptor Gene 147 273-276.
151. Sjövall J & Axelson M 1982 Newer approaches to the isolation, identification and quantitation of steroids in biological materials. Vitamins and Hormones 39 31-44.
152. Sjövall J & Axelson M 1984 Sample work-up by column techniques. Journal of Pharmaceutical and Biomedical Analysis 2 265-280.
153. Sladek FM, Zhong WM, Lai E & Darnell JE Jr 1990 Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes and Development 4 2353-2365.
154. Smith CL, Conneely OM & O'Malley BW 1993 Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proceedings of the National Academy of Sciences of the USA 90 6120-6124.
155. Smith DP, Mason CS, Jones EA & Old RW 1994 A novel nuclear receptor superfamily member in Xenopus that associates with RXR and shares extensive sequence similarity to the mammalian vitamin D3 receptor. Nucleic Acids Research 22 66-71
156. Song C, Kokontis JM, Hiipakka RA & Liao S 1994 Ubiquitous receptor, a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors Proceedings of the National Academy of Sciences of the USA 91 10809-10813.
157. Stone BL & Thummel CS 1993 The Drosophila 78C early late puff contains E78 an ecdysone-inducable gene that encodes a novel member of the nuclear hormone receptor superfamily. Cell 75 307-320.
158. Sumida C 1995 Fatty acids: ancestral ligands and modern co-regulators of the steroid hormone receptor cell signalling pathway. Prostaglandins Leukotrienes and Essential Fatty Acids 52 137-144.
159. Tai PK, Maeda Y, Nakao K, Wakim NG, Duhring JL & Faber LE 1986 A 59-kilodalton protein associated with progestin estrogen androgen and glucocorticoid receptors. Biochemistry 25 5269-5275.
160. Takimoto GS, Tasset DM, Eppert AC & Horwitz KB 1992 Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299. Proceedings of the National Academy of Sciences of the USA 89 3050-3054.
161. Teboul M, Enmark E, Li Q, Wikström AC, Pelto-Huikko M & Gustafsson J-Å 1995 OR-1 a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proceedings of the National Academy of Sciences of the USA 92 2096-2100.
162. Thompson CC, Weinberger C, Lebo R & Evans RM 1987 Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system. Science 237 1610-1614.
163. Tontonoz P, Hu E, Graves RA, Budavari AI & Spiegelman BM 1994 mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes and Development 8 1224-1234.
164. Tontonoz P, Hu E, Devine J, Beale EG & Spiegelman BM 1995 PPAR gamma 2 regulates adipose expression of phosphoenolpyruvate carboxykinase gene. Molecular and Cellular Biology 15 351-357.
165. Tora L, Gronemeyer H, Turcotte B, Gaub MP & Chambon P 1988 The N-terminal region of the chicken progesterone receptor specifies target gene activation. Nature 333 185-188
166. Tran P, Zhang XK, Salbert G, Hermann T, Lehmann JM & Pfahl M 1992 COUP orphan receptors are negative regulators of retinoic acid response pathways. Molecular and Cellular Biology 12 4666-4676
167. Truss M & Beato M 1993 Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocrine Reviews 14 459-479.
168. Tsai M-J & O'Malley B 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annual Review of Biochemistry 63 451-486.
169. Tsukiyama T, Ueda H, Hirose S & Niwa O 1992 Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1 a member of the steroid receptor superfamily. Molecular and Cellular Biology 12 1286-1291
170. Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL & Green S 1992 The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene EMBO Journal 11 433-439
171. Vegeto E, Allan GF, Schrader WT, Tsai M-J, McDonnell DP & O'Malley BW 1992 The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor Cell 69 703-713.
172. Vu-Dac N, Schoonjans K, Laine B, Fruchart JC, Auwerx J & Staels B 1994 Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. Journal of Biological Chemistry 269 31012-31018.
173. Wahli W, Braissant O & Desvergne B 1995 Peroxisome proliferator-activated receptors: transcriptional regulators of adipogenesis lipid metabolism and more. Chemistry and Biology 2 261-266.
174. Wang L-H, Tsai SY, Cook RG, Beattie WG, Tsai M-J & O'Malley BW 1989 COUP transcription factor is a member of the steroid receptor superfamily. Nature 340 163-166.
175. Wang L-H, Ing NH, Tsai SY, O'Malley BW & Tsai M-J 1991 The COUP-TFs compose a family of functionally related transcription factors Gene Expression 1 207-216.
176. Watson MA & Milbrandt J 1989 The NGFI-B gene a transcriptionally inducible member of the steroid receptor gene superfamily: genomic structure and expression in rat brain after seizure induction. Molecular and Cellular Biology 9 4213-4219.
177. Webster NJ, Green S, Jin JR & Chambon P 1988 The hormone binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54 199-207.
178. Weigel NL, Carter TH, Schrader WT & O'Malley BW 1992 Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays Molecular Endocrinology 6 8-14
179. Weinberger C & Bradley DJ 1990 Gene regulation by receptors binding lipid-soluble substances Annual Review of Physiology 52 823-844.
180. Weinberger C, Thompson CC, Ong ES, Lebo R, Gruol DJ & Evans RM 1986 The c-erb-A gene encodes a thyroid hormone receptor. Nature 324 641-646.
181. Weinberger C, Oro A, Bradley D & Noonan D 1994 Characterisation of a hormone responsive orphan nuclear receptor. Journal of Cellular Biochemistry 18B (suppl) 350 (poster K141).
182. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA & Mangelsdorf DJ 1995 LXR a nuclear receptor that defines a distinct retinoid response pathway. Genes and Development 9 1033-1045.
183. Wilson R, Ainscough R, Anderson K, Baynes C, Berks M, Bonfield J, Burton J, Connell M, Copsey T, Cooper J et al. 1994 22 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368 32-38.
184. Wilson TE, Paulsen RE, Padgett KA & Milbrandt J 1992 Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Science 256 107-110.
185. Yu RT, McKeown M, Evans RM & Umesono K 1994 Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor TIx. Nature 370 375-379.
186. Zanaria E, Muscatelli F, Bardoni B, Strom TM, Guioli S, Guo W, Lalli E, Moser C, Walker AP, McCabe ER, Meitinger T, Monaco AP, Sassone-Corsi P & Camerino G 1994 An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372 635-641.
187. Zelent A, Mendelsohn C, Kastner P, Krust A, Garnier JM, Ruffenach F, Leroy P & Chambon P 1991 Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing. EMBO Journal 10 71-81.
188. Zeng Z, Allan GF, Thaller C, Cooney AJ, Tsai SY, O'Malley BW & Tsai M-J 1994 Detection of potential ligands for nuclear receptors in cellular extracts. Endocrinology 135 248-252.