Effects of losartan on cerebral arteries in stroke-prone spontaneously hypertensive rats

Journal of Hypertension

Volumn 14, Issue 11, 1996, Pages 1341-1348

  Vacher, Elisabeth ^a   Richer, Christine ^a   Giudicelli, Jean François ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Ex vivo middle cerebral artery reactivity; Losartan; Middle cerebral artery structural changes; Stroke prone spontaneously hypertensive rats

Indexed keywords

BRADYKININ; LOSARTAN; NITROPRUSSIDE SODIUM; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; POTASSIUM CHLORIDE; SEROTONIN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY WALL; ARTICLE; BRAIN ARTERY; CELL FUNCTION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; LONG TERM CARE; MALE; MALIGNANT HYPERTENSION; MIDDLE CEREBRAL ARTERY; MORPHOLOGY; MYOGRAPHY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; STRUCTURE ACTIVITY RELATION; THICKNESS; VASCULAR SMOOTH MUSCLE;

EID: 0029958211     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199611000-00013     Document Type: Article

References (41)

1. Sandercock PAG, Warlow CP, Jones LN, Starkey IR: Predisposing factors for cerebral infarction: the Oxfordshire community stroke project. BMJ 1989, 298:75-80.
2. Okamoto K, Yamori Y, Nagaoka A: Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 1974, 34-35 (suppl I): I143-I153.
3. Ogata J, Fujishima M, Tamaki K, Nakatomi Y, Ishitsuka T, Omae T: Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension. I. A light- and electron-microscopic study of the brain. Acta Neuropathol 1980, 51:179-184.
4. Fornes P, Richer C, Vacher E, Bruneval P, Giudicelli JF: Losartan's protective effects in stroke-prone spontaneously hypertensive rats persist durably after treatment withdrawal. J Cardiovasc Pharmacol 1993, 22:305-313.
5. Mayhan WG, Faraci FM, Heistad DD: Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension. Am J Physiol 1987, 253:H1435-H1440.
6. Mayhan WG, Faraci FM, Heistad DD: Responses of cerebral arterioles to adenosine 5′-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension. Hypertension 1988, 12: 556-561.
7. Yang ST, Mayhan WG, Faraci FM, Heistad DD: Endothelium-dependent responses of cerebral blood vessels during chronic hypertension. Hypertension 1991, 17:612-618.
8. Baumbach GL, Dobrin PB, Hart MN, Heistad DD: Mechanics of cerebral arterioles in hypertensive rats. Circ Res 1988, 62:56-64.
9. Smeda JS: Cerebral vascular changes associated with hemorrhagic stroke in hypertension. Can J Physiol Pharmacol 1992, 70:552-564.
10. Stier CT, Benter IF, Ahmad S, Zuo H, Selig N, Roethel S, et al.: Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats. Hypertension 1989, 13:115-121.
11. Stier CT, Chander PN, Gutstein WH, Levine S, Itskovitz HD: Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect. Am J Hypertens 1991, 4:680-687.
12. Vacher E, Fornes P, Domergue V, Richer C, Bruneval P, Giudicelli JF: Quinapril prevents stroke both during and after the treatment period in stroke-prone spontaneously hypertensive rats. Am J Hypertens 1993, 6:951-959.
13. Richer C, Fornes P, Vacher E, Bruneval P, Giudicelli JF: Trandolapril's protective effects in stroke-prone spontaneously hypertensive rats persist after treatment withdrawal. Am J Cardiol 1994, 73:26C-35C.
14. Camargo MJF, Von Lutterotti N, Pecker MS, James GD, Timmermans PBMWM, Laragh JH: DuP 753 increases survival in spontaneously hypertensive stroke-prone rats fed a high sodium diet. Am J Hypertens 1991, 4:S341-S345.
15. Bunag RD, Butterfield J: Tail-cuff blood pressure measurement without external preheating in awake rats. Hypertension 1982, 4:898-903.
16. Mulvany MJ, Halpern W: Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977, 41:19-26.
17. Ludbrook J: Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc Res 1994, 28:303-311.
18. Hajdu M, Baumbach GL: Mechanics of large and small cerebral arteries in chronic hypertension. Am J Physiol 1994, 266:H1027-H1033.
19. Yamori Y, Horie T, Tanase H, Fujiwara K, Nara Y, Lovenberg W: Possible role of nutritional factors in the incidence of cerebral lesions in stroke-prone spontaneously hypertensive rats. Hypertension 1984, 6:49-53.
20. Horie R, Yamori Y, Nara Y, Sawamura M, Mizushima S: Aggravating effects of isolated caging of the development of hypertension and its complications in stroke-prone spontaneously hypertensive rats (SHR-SP) and Wistar-Kyoto rats (WKY). Clin Exp Hypertens [A] 1991, 13: 859-864.
21. Shibota M, Nagaoka A, Shino A, Fujita T: Renin-angiotensin system in stroke-prone spontaneously hypertensive rats. Am J Physiol 1979, 236: H409-H416.
22. Yamori Y, Horie R: Developmental course of hypertension and regional cerebral blood flow in stroke-prone spontaneously hypertensive rats. Stroke 1977, 8:456-461.
23. Kazda S, Grunt M, Hirth C, Preis W, Stasch JP: Calcium antagonism and protection of tissues from calcium damage. J Hypertens 1987, 5 (suppl 4):S37-S42.
24. Lens L, Luckhaus G, Stasch JP, Kazda S: Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine. Stroke 1990, 21 (suppl IV):IV111-IV112.
25. Gries J, Kretzschmar R, Neumann BW: Development of hypertension and lifespan in stroke-prone spontaneously hypertensive rats during oral long-term treatment with various antihypertensive drugs. J Cardiovasc Pharmacol 1989, 13 (suppl 4):S79-S82.
26. Takakura S, Furuichi Y, Yamamoto T, Ogawa T, Satoh H, Mori J: Effect of nilvadipine on the development of neurological deficits in stroke-prone spontaneously hypertensive rats. Stroke 1994, 25:677-683.
27. Shinyama H, Nagai H, Kawamura T, Narita Y, Uchida T, Watanabe M, et al.: Protective effects of AE0047, a novel calcium antagonist, on incidence of stroke and hemodynamic disturbances in stroke-prone spontaneously hypertensive rats. J Pharmacol Exp Ther 1995, 272: 911-919.
28. Vacher E, Richer C, Fornes P, Clozel JP, Giudicelli JF: Mibefradil, a selective calcium T-channel blocker, in stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 1996, 27:686-694.
29. Brayden JE, Halpern W, Brann LR: Biochemical and mechanical properties of resistance arteries from normotensive and hypertensive rats. Hypertension, 1983, 5:17-25.
30. Contard F, Sabri A, Glukhova M, Sartore S, Marotte F, Pomies JP, et al.: Arterial smooth muscle cell phenotype in stroke-prone spontaneously hyperensive rats. Hypertension 1993, 22:665-676.
31. Saouaf R, Takasaki I, Eastman E, Chobanian AV, Brecher P: Fibronectin biosynthesis in the rat aorta in vitro: changes due to experimental hypertension. J Clin Invest 1991, 88:1182-1189.
32. Himeno H, Hosoi M, Brecher P, Chobanian AV: Angiotensin II alters fibronectin gene expression in rat aortic tissue by a mechanism independent of blood pressure elevation [abstract]. Hypertension 1993, 22:414.
33. Kobayashi Y, Ikeda K, Shinozuka K, Nara Y, Yamori Y, Hattori K: Endothelium-dependent and -independent vasodilations of stroke-prone spontaneously hypertensive rats with stroke. In Genetic Hypertension. Edited by Sassard J. London: INSERM-John Libbey Publishers; 1992:51-53.
34. Tesfamariam B, Halpern W: Endothelium-dependent and endothelium-independent vasodilation in resistance arteries from hypertensive rats. Hypertension 1988, 11:440-444.
35. Diederich D Yang Z, Bvthler FR, Lvtscher TF: Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway. Am J Physiol 1990, 258:H445-H451.
36. Mayhan WG: Impairment of endothelium-dependent dilatation of basilar artery during chronic hypertension. Am J Physiol 1990, 259: H1455-H1462.
37. Yang ST, Faraci FM, Heistad DD: Effects of cilazapril on cerebral vasodilatation in hypertensive rats. Hypertension 1993, 22:150-155
38. Sudhir K, McGregor JS, Gupta M, Barbant SD, Redberg R, Yock PG, et al.: Effect of selective angiotensin II receptor antagonism and angiotensin converting enzyme inhibition on the coronary vasculature in vivo. Circulation 1993, 87:931-938.
39. Jaiswal N, Diz DI, Tallant EA, Khosha MA, Ferracio CM: The non-peptide angiotensin II antagonist DUP 753 is a potent stimulus for prostacyclin synthesis. Am J Hypertens 1991, 4:228-233.
40. 2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist. J Pharmacol Exp Ther 1994, 268:747-752.
41. Ishizaki H, Ohtawa M: Inhibitory effect of the nonpeptide angiotensin II receptor antagonist losartan and its active metabolite, E-3174, on cAMP phosphodies-terase: additional action of the antagonists. Biochem Pharmacol 1994, 48:201-204.