-
1
-
-
0016961001
-
Isolation of lymphocytes, granulocytes and macrophages
-
Boyum, A. (1976) Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. 5:(Suppl. 5) 5-15
-
(1976)
Scand. J. Immunol.
, vol.5
, Issue.5 SUPPL.
, pp. 5-15
-
-
Boyum, A.1
-
2
-
-
0141601966
-
4-Substituted quinuclidium perchlorates in the determination of polar substituent effects
-
Ceppi, E., Eckhardt, W., Grob, C. A. (1973) 4-Substituted quinuclidium perchlorates in the determination of polar substituent effects. Tetrahedron Lett. 37: 3627-3630
-
(1973)
Tetrahedron Lett.
, vol.37
, pp. 3627-3630
-
-
Ceppi, E.1
Eckhardt, W.2
Grob, C.A.3
-
3
-
-
0027366832
-
Dapsone: Modes of action, toxicity and possible strategies for increasing patient tolerance
-
Coleman, M. D. (1993) Dapsone: modes of action, toxicity and possible strategies for increasing patient tolerance. Br. J. Dermatol. 129: 507-513
-
(1993)
Br. J. Dermatol.
, vol.129
, pp. 507-513
-
-
Coleman, M.D.1
-
4
-
-
0027433323
-
Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in-vitro. II. Movement of dapsone across a semipermeable membrane into erythrocytes and plasma
-
Coleman, M. D., Jacobus, D. P. (1993) Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in-vitro. II. Movement of dapsone across a semipermeable membrane into erythrocytes and plasma. Biochem. Pharmacol. 46: 1363-1368
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1363-1368
-
-
Coleman, M.D.1
Jacobus, D.P.2
-
5
-
-
0024466393
-
Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes
-
Coleman, M. D., Breckenridge, A. M., Park, B. K. (1989) Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes. Br. J. Clin. Pharmacol. 28: 389-395
-
(1989)
Br. J. Clin. Pharmacol.
, vol.28
, pp. 389-395
-
-
Coleman, M.D.1
Breckenridge, A.M.2
Park, B.K.3
-
6
-
-
0025038855
-
The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man
-
Coleman, M. D., Scott, A. K., Breckenridge, A. M., Park, B. K. (1990a) The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man. Br. J. Clin. Pharmacol. 30: 761-767
-
(1990)
Br. J. Clin. Pharmacol.
, vol.30
, pp. 761-767
-
-
Coleman, M.D.1
Scott, A.K.2
Breckenridge, A.M.3
Park, B.K.4
-
7
-
-
0025162718
-
Gonadal influence on the metabolism and haematological toxicity of dapsone in the rat
-
Coleman, M. D., Tingle, M. D., Winn, M. J., Park, B. K. (1990b) Gonadal influence on the metabolism and haematological toxicity of dapsone in the rat J. Pharm. Pharmacol. 42 698-703
-
(1990)
J. Pharm. Pharmacol.
, vol.42
, pp. 698-703
-
-
Coleman, M.D.1
Tingle, M.D.2
Winn, M.J.3
Park, B.K.4
-
8
-
-
0025995577
-
An investigation into the haematological toxicity of structural analogues of dapsone in-vivo and in-vitro
-
Coleman, M. D., Tingle, M. D., Hussain, F., Storr, R. C., Park, B. K. (1991) An investigation into the haematological toxicity of structural analogues of dapsone in-vivo and in-vitro. J. Pharm. Pharmacol. 43: 779-784
-
(1991)
J. Pharm. Pharmacol.
, vol.43
, pp. 779-784
-
-
Coleman, M.D.1
Tingle, M.D.2
Hussain, F.3
Storr, R.C.4
Park, B.K.5
-
9
-
-
0019544354
-
Down with multiple t tests
-
Elashoff, J. D. (1981) Down with multiple t tests. Gastroenterology 80: 615-620
-
(1981)
Gastroenterology
, vol.80
, pp. 615-620
-
-
Elashoff, J.D.1
-
10
-
-
0027984941
-
Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer
-
Fleming, C. M., Persad, R., Kaisary, A., Smith, P., Adedoyin, A., Porter, J., Wilkinson, G. R., Branch, R. A. (1994) Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer. Pharmacogenetics 4: 199-207
-
(1994)
Pharmacogenetics
, vol.4
, pp. 199-207
-
-
Fleming, C.M.1
Persad, R.2
Kaisary, A.3
Smith, P.4
Adedoyin, A.5
Porter, J.6
Wilkinson, G.R.7
Branch, R.A.8
-
11
-
-
0027223881
-
Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme
-
Gillam, E. M. J., Baba, T., Kim, B. R., Ohmori, S., Guengerich, F. P. (1993) Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme. Arch. Biochem. Biophys. 305 123-131
-
(1993)
Arch. Biochem. Biophys.
, vol.305
, pp. 123-131
-
-
Gillam, E.M.J.1
Baba, T.2
Kim, B.R.3
Ohmori, S.4
Guengerich, F.P.5
-
12
-
-
0026336750
-
Expression of mammalian cytochrome P-450 enzymes using yeast vectors
-
Guengerich, F. P., Brian, W. R., Sari, M. A., Ross, J. T. (1991) Expression of mammalian cytochrome P-450 enzymes using yeast vectors. Methods Enzymol. 206: 130-144
-
(1991)
Methods Enzymol.
, vol.206
, pp. 130-144
-
-
Guengerich, F.P.1
Brian, W.R.2
Sari, M.A.3
Ross, J.T.4
-
13
-
-
0015748301
-
Studies of the metabolism of DDS in man and experimental animals. Formation of N-hydroxy metabolites
-
Israili, Z. H., Cucinell, S. A., Vaught, J., Davis, B., Zesser, J. M., Dayton, P. G. (1973) Studies of the metabolism of DDS in man and experimental animals. Formation of N-hydroxy metabolites. J. Pharmacol. Exp. Ther. 187: 138-151
-
(1973)
J. Pharmacol. Exp. Ther.
, vol.187
, pp. 138-151
-
-
Israili, Z.H.1
Cucinell, S.A.2
Vaught, J.3
Davis, B.4
Zesser, J.M.5
Dayton, P.G.6
-
14
-
-
0026716030
-
Synthesis of new 2,4, diaminobenzylpyrimidines active against various bacterial species
-
Kansy, M., Seydel, J. K., Wiese, M., Haller, R. (1992) Synthesis of new 2,4, diaminobenzylpyrimidines active against various bacterial species. Eur. J. Med. Chem. 27: 237-244
-
(1992)
Eur. J. Med. Chem.
, vol.27
, pp. 237-244
-
-
Kansy, M.1
Seydel, J.K.2
Wiese, M.3
Haller, R.4
-
15
-
-
84907127080
-
Genetic and physiological analysis of azole sensitivity in Saccharomysces cerevisiae
-
Kenna, S., Bligh, H. F., Watson, P. F., Kelly, S. L. (1989) Genetic and physiological analysis of azole sensitivity in Saccharomysces cerevisiae. J. Med. Vet. Mycol. 27 397-406
-
(1989)
J. Med. Vet. Mycol.
, vol.27
, pp. 397-406
-
-
Kenna, S.1
Bligh, H.F.2
Watson, P.F.3
Kelly, S.L.4
-
16
-
-
0344248220
-
Kinetik der Hamiglobinbildung. IV Mitteilung. Die Hamiglobinbildung durch Phenylhydroxylamin und Nitrosobenzol in roten Zellen in vitro
-
Kiese, M., Reinwein, D., Waller, H. D. (1950) Kinetik der Hamiglobinbildung. IV Mitteilung. Die Hamiglobinbildung durch Phenylhydroxylamin und Nitrosobenzol in roten Zellen in vitro. Naunyn Schmiedebergs Arc. Exp. Path. Pharmacol. 210: 393-398
-
(1950)
Naunyn Schmiedebergs Arc. Exp. Path. Pharmacol.
, vol.210
, pp. 393-398
-
-
Kiese, M.1
Reinwein, D.2
Waller, H.D.3
-
17
-
-
0011367602
-
A comparison of QSARs proposed for the inhibition of dihydropteroate synthetase by substituted 4-aminodiphenylsulfones
-
Koehler, M. G., Hopfinger, A. J. (1988) A comparison of QSARs proposed for the inhibition of dihydropteroate synthetase by substituted 4-aminodiphenylsulfones. J. Mol. Structure (Theochem) 179: 319-332
-
(1988)
J. Mol. Structure (Theochem)
, vol.179
, pp. 319-332
-
-
Koehler, M.G.1
Hopfinger, A.J.2
-
18
-
-
0028986596
-
CO binding kinetics of human cytochrome P-450 3A4
-
Koley, A. P., Buters, J. T. M., Robinson, R. C., Markowitz, A., Friedman, F. K. (1995) CO binding kinetics of human cytochrome P-450 3A4. J.Biol. Chem. 270: 5014-5018
-
(1995)
J.Biol. Chem.
, vol.270
, pp. 5014-5018
-
-
Koley, A.P.1
Buters, J.T.M.2
Robinson, R.C.3
Markowitz, A.4
Friedman, F.K.5
-
19
-
-
0015345305
-
Mechanism of methaemoglobin formation by diphenylsulphones
-
Kramer, P. A., Glader, B. E., Li, T. K. (1972) Mechanism of methaemoglobin formation by diphenylsulphones. Biochem. Pharmacol. 21: 1265-1274
-
(1972)
Biochem. Pharmacol.
, vol.21
, pp. 1265-1274
-
-
Kramer, P.A.1
Glader, B.E.2
Li, T.K.3
-
20
-
-
0024503778
-
Dapsone, trimethoprim and sulfamethoxazole plasma levels during treatment of pneumocystis pneumonia in patients with the acquired immune deficiency syndrome (AIDS)
-
Lee, B. L., Medina, I., Benowitz, N. L., Jacob, P., Wofsy, C. B., Mills, J. (1989) Dapsone, trimethoprim and sulfamethoxazole plasma levels during treatment of pneumocystis pneumonia in patients with the acquired immune deficiency syndrome (AIDS). Ann. Intern. Med. 110: 606-611
-
(1989)
Ann. Intern. Med.
, vol.110
, pp. 606-611
-
-
Lee, B.L.1
Medina, I.2
Benowitz, N.L.3
Jacob, P.4
Wofsy, C.B.5
Mills, J.6
-
21
-
-
0018581446
-
Studies on dapsone-induced haemolytic anaemia: Methaemoglobin production and glucose 6-phosphate activity in correlation with dapsone dosage
-
Manfredi, G., De Panfilis, G., Zampetti, M., Allegra, F. (1979) Studies on dapsone-induced haemolytic anaemia: methaemoglobin production and glucose 6-phosphate activity in correlation with dapsone dosage. Br. J. Dermatol. 100: 427-432
-
(1979)
Br. J. Dermatol.
, vol.100
, pp. 427-432
-
-
Manfredi, G.1
De Panfilis, G.2
Zampetti, M.3
Allegra, F.4
-
22
-
-
0002775658
-
Metabolism of arylamines by human liver microsomal cytochrome P-450(S)
-
Tucson, AZ, USA, Oct 17-21
-
Mitra, A. K., Kalhorn, T. F., Thummel, K. E., Unadkat, J. A., Slattery, J. T. (1993) Metabolism of arylamines by human liver microsomal cytochrome P-450(S). Proc. ISSX, Fifth North American Meeting, Tucson, AZ, USA, Oct 17-21, p. 148
-
(1993)
Proc. ISSX, Fifth North American Meeting
, pp. 148
-
-
Mitra, A.K.1
Kalhorn, T.F.2
Thummel, K.E.3
Unadkat, J.A.4
Slattery, J.T.5
-
23
-
-
0002961151
-
Metabolism of dapsone in human liver by cytochrome P-450 2E1
-
Raleigh, NC, USA, Oct 23-27
-
Mitra, A. K., Thummel, K. E., Unadkat, J. A., Slattery, J .T. (1994) Metabolism of dapsone in human liver by cytochrome P-450 2E1. Proc. Sixth North American Meeting, Raleigh, NC, USA, Oct 23-27, p. 248
-
(1994)
Proc. Sixth North American Meeting
, pp. 248
-
-
Mitra, A.K.1
Thummel, K.E.2
Unadkat, J.A.3
Slattery, J.T.4
-
24
-
-
0028662025
-
P450 in the rat and man: Methods of investigation, substrate specificities and relevance to cancer
-
Nedelcheva, V., Gut, I. (1994) P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer. Xenobiotica 24: 1151-1175
-
(1994)
Xenobiotica
, vol.24
, pp. 1151-1175
-
-
Nedelcheva, V.1
Gut, I.2
-
25
-
-
78651165715
-
The carbon monoxide binding pigmant of liver microsomes
-
Omura, T., Sato, R. (1964) The carbon monoxide binding pigmant of liver microsomes. J. Biol. Chem. 239: 2370-2385
-
(1964)
J. Biol. Chem.
, vol.239
, pp. 2370-2385
-
-
Omura, T.1
Sato, R.2
-
26
-
-
0024450737
-
Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones
-
Pieper, H., Seydel, J. K., Kruger, G., Noll, K., Keck, J., Wiese, M. (1989) Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones. Arzn. Forsch. 39: 1073-1080
-
(1989)
Arzn. Forsch.
, vol.39
, pp. 1073-1080
-
-
Pieper, H.1
Seydel, J.K.2
Kruger, G.3
Noll, K.4
Keck, J.5
Wiese, M.6
-
27
-
-
0025734129
-
Direct and indirect toxicity of sulphasalazine and its principle metabolites towards human leucocytes and erythrocytes
-
Pirmohamed, M., Coleman, M. D., Hussain, F., Breckenridge, A. M., Park, B. K. (1991) Direct and indirect toxicity of sulphasalazine and its principle metabolites towards human leucocytes and erythrocytes. Br. J. Clin. Pharmacacol. 32: 303-311
-
(1991)
Br. J. Clin. Pharmacacol.
, vol.32
, pp. 303-311
-
-
Pirmohamed, M.1
Coleman, M.D.2
Hussain, F.3
Breckenridge, A.M.4
Park, B.K.5
-
28
-
-
0023236937
-
The metabolism of 17αethinyloestradiol by human liver microsomes: Formation of catechol and chemically reactive metabolites
-
Purba, H. S., Maggs, J. L., Orme, M. L'E., Back, D. J., Park, B. K. (1987) The metabolism of 17αethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites. Br. J. Clin. Pharmacol. 23: 447-453
-
(1987)
Br. J. Clin. Pharmacol.
, vol.23
, pp. 447-453
-
-
Purba, H.S.1
Maggs, J.L.2
Orme, M.L'E.3
Back, D.J.4
Park, B.K.5
-
29
-
-
0011319402
-
Trimethoprim, a novel antibacterial agent
-
Roth, B., Falco, E. A., Hitchings, G. H., Bushby, J. R. H. (1961) Trimethoprim, a novel antibacterial agent. J. Med. Chem. 5: 1103-1116
-
(1961)
J. Med. Chem.
, vol.5
, pp. 1103-1116
-
-
Roth, B.1
Falco, E.A.2
Hitchings, G.H.3
Bushby, J.R.H.4
-
30
-
-
0026569805
-
Cytochromes P-450 in rats: Structures, functions,properties and relevant human forms
-
Soucek, P., Gut, I. (1992) Cytochromes P-450 in rats: structures, functions,properties and relevant human forms. Xenobiotica 22: 83-103
-
(1992)
Xenobiotica
, vol.22
, pp. 83-103
-
-
Soucek, P.1
Gut, I.2
-
31
-
-
0021125859
-
In-vitro assessment of pharmacogenetic susceptibility to toxic metabolites in humans
-
Spielberg, S. P. (1984) In-vitro assessment of pharmacogenetic susceptibility to toxic metabolites in humans. Fed. Proc. 43: 2308-2313
-
(1984)
Fed. Proc.
, vol.43
, pp. 2308-2313
-
-
Spielberg, S.P.1
-
32
-
-
0014915596
-
Trimethoprim metabolites in the rat, dog and man: Qualitative and quantitative studies
-
Schwartz, D. E., Vetter, W., Englert, G. (1970) Trimethoprim metabolites in the rat, dog and man: qualitative and quantitative studies. Arzeimittelforschung 20; 1867-1871
-
(1970)
Arzeimittelforschung
, vol.20
, pp. 1867-1871
-
-
Schwartz, D.E.1
Vetter, W.2
Englert, G.3
-
33
-
-
0025611212
-
Investigation into the role of metabolism in dapsone-induced methaemoglobinaemia using a two-compartment in-vitro test system
-
Tingle, M. D., Coleman, M. D., Park, B. K. (1990) Investigation into the role of metabolism in dapsone-induced methaemoglobinaemia using a two-compartment in-vitro test system. Br. J. Clin. Pharmacol. 30: 829-838
-
(1990)
Br. J. Clin. Pharmacol.
, vol.30
, pp. 829-838
-
-
Tingle, M.D.1
Coleman, M.D.2
Park, B.K.3
-
34
-
-
0025740328
-
Effects of pre-incubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes
-
Tingle, M. D., Coleman, M. D., Park, B. K. (1991) Effects of pre-incubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes. Br. J. Clin. Pharmacol. 32: 120-124
-
(1991)
Br. J. Clin. Pharmacol.
, vol.32
, pp. 120-124
-
-
Tingle, M.D.1
Coleman, M.D.2
Park, B.K.3
-
35
-
-
0027730713
-
Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis
-
Torres, R. A., Barr, M., Thorn, M., Gregory, G., Kiely, W., Chanin, E., Carlo, C., Nartin, M., Thornton, J. (1993) Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. Am. J. Med. 95: 573-583
-
(1993)
Am. J. Med.
, vol.95
, pp. 573-583
-
-
Torres, R.A.1
Barr, M.2
Thorn, M.3
Gregory, G.4
Kiely, W.5
Chanin, E.6
Carlo, C.7
Nartin, M.8
Thornton, J.9
-
36
-
-
0027980609
-
Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P-450 2C6/2C11 and 3A1
-
Vage, C., Svensson, C. K. (1994) Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P-450 2C6/2C11 and 3A1. Drug Metab. Dispos. 22: 572-577
-
(1994)
Drug Metab. Dispos.
, vol.22
, pp. 572-577
-
-
Vage, C.1
Svensson, C.K.2
-
37
-
-
0028097910
-
Interaction of Pneumocystis carinii dihydropteroate synthetase with sulphonamides and diaminodiphenyl sulfone
-
Voeller, D., Kovacs, J., Andrawis, V., Chu E Masur, H., Allegra, C. (1994) Interaction of Pneumocystis carinii dihydropteroate synthetase with sulphonamides and diaminodiphenyl sulfone. J. Infect. Dis. 169: 456-459
-
(1994)
J. Infect. Dis.
, vol.169
, pp. 456-459
-
-
Voeller, D.1
Kovacs, J.2
Andrawis, V.3
Chu, E.4
Masur, H.5
Allegra, C.6
-
38
-
-
0028071759
-
Non-invasive tests of CYP3A enzymes
-
Watkins, P. B. (1994) Non-invasive tests of CYP3A enzymes. Pharmacogenetics 4: 171-184
-
(1994)
Pharmacogenetics
, vol.4
, pp. 171-184
-
-
Watkins, P.B.1
-
39
-
-
0023501974
-
Multiple regression analysis of antimalarial activities of sulfones and sulfonamides in cell-free systems and principal component analysis to compare with antibacterial activities
-
Wiese, M., Seydel, J. K., Pieper, H., Kruger, G., Noll, K. R., Keck, J. (1987) Multiple regression analysis of antimalarial activities of sulfones and sulfonamides in cell-free systems and principal component analysis to compare with antibacterial activities. Quant. Struct.-Act. Relat. 6: 164-172
-
(1987)
Quant. Struct.-Act. Relat.
, vol.6
, pp. 164-172
-
-
Wiese, M.1
Seydel, J.K.2
Pieper, H.3
Kruger, G.4
Noll, K.R.5
Keck, J.6
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