메뉴 건너뛰기




Volumn 6, Issue 1, 1996, Pages 1-11

The role of herpes simplex thymidine kinase gene transfer in the drug treatment of brain tumours

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

EID: 0029957749     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199606010-00001     Document Type: Review
Times cited : (4)

References (63)
  • 2
    • 0025403865 scopus 로고
    • Long-term expression of human adenosine deaminase in mice after transplantation of bone marrow infected with amphotropic retroviral vectors
    • Osborne WRA, Hock RA, Kaleko M, et al. Long-term expression of human adenosine deaminase in mice after transplantation of bone marrow infected with amphotropic retroviral vectors. Hum Gene Ther 1990; 1: 31-41
    • (1990) Hum Gene Ther , vol.1 , pp. 31-41
    • Osborne, W.R.A.1    Hock, R.A.2    Kaleko, M.3
  • 3
    • 0028807727 scopus 로고
    • T lymphocyte-directed gene therapy for ADA-SCID: Initial trial results after 4 years
    • Blaese RM, Culver KW, Miller AD, et al. T lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science 1995; 270: 475-80
    • (1995) Science , vol.270 , pp. 475-480
    • Blaese, R.M.1    Culver, K.W.2    Miller, A.D.3
  • 6
    • 0019299220 scopus 로고
    • The chemotherapeutic exploitation of virus-specified enzymes
    • Elion GB. The chemotherapeutic exploitation of virus-specified enzymes. Adv Enz Regulation 1980; 18: 53-66
    • (1980) Adv Enz Regulation , vol.18 , pp. 53-66
    • Elion, G.B.1
  • 7
    • 0018648124 scopus 로고
    • Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12
    • Colbere-Garapin F, Chousterman S, Horodniceanu F, et al. Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12. Proc Natl Acad Sci USA 1979; 76: 3755-9
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 3755-3759
    • Colbere-Garapin, F.1    Chousterman, S.2    Horodniceanu, F.3
  • 8
    • 0025233918 scopus 로고
    • Ganciclovir: A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections
    • Faulds D, Heel RC. Ganciclovir: a review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs 1990; 39: 597-38
    • (1990) Drugs , vol.39 , pp. 597-638
    • Faulds, D.1    Heel, R.C.2
  • 9
    • 0026001583 scopus 로고
    • Inhibition of herpes simplex virus type 1 DNA polymerase by [1R(1a,2b,3a)]-9-[2,3-Bis(hydroxymethyl)cyclobutyl]guanine
    • Terry BJ, Cianci CW, Hagen ME. Inhibition of herpes simplex virus type 1 DNA polymerase by [1R(1a,2b,3a)]-9-[2,3-Bis(hydroxymethyl)cyclobutyl]guanine. Mol Pharm 1991; 40: 591-6
    • (1991) Mol Pharm , vol.40 , pp. 591-596
    • Terry, B.J.1    Cianci, C.W.2    Hagen, M.E.3
  • 10
    • 0020614981 scopus 로고
    • Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine
    • Smee DF, Martin JC, Verheyden JPH, et al. Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine. Antimicrob Agents Chemother 1983; 23: 676-82
    • (1983) Antimicrob Agents Chemother , vol.23 , pp. 676-682
    • Smee, D.F.1    Martin, J.C.2    Verheyden, J.P.H.3
  • 11
    • 0028860037 scopus 로고
    • 'Bystander killing' induces apoptosis and is inhibited by forskolin: Plasmid pXtk construction for thymidine-kinase gene transfer to investigate bystander killing
    • Samejima Y, Meruelo D. 'Bystander killing' induces apoptosis and is inhibited by forskolin: plasmid pXtk construction for thymidine-kinase gene transfer to investigate bystander killing. Gene Ther 1995; 2: 50-8
    • (1995) Gene Ther , vol.2 , pp. 50-58
    • Samejima, Y.1    Meruelo, D.2
  • 12
    • 0020262167 scopus 로고
    • 9-([2-hydroxy-1-(hyroxymethyl)ethoxy]methyl)guanine: A selective inhibitor of herpes group virus replication
    • Field AK, Davies ME, DeWitt C, et al. 9-([2-hydroxy-1-(hyroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci USA 1983; 80: 4139-43
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4139-4143
    • Field, A.K.1    Davies, M.E.2    DeWitt, C.3
  • 14
    • 0022485359 scopus 로고
    • Tumor sensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a perspective cancer control strategy
    • Moolten FL. Tumor sensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a perspective cancer control strategy. Cancer Res 1986; 46: 5276-81
    • (1986) Cancer Res , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 15
    • 0025899005 scopus 로고
    • Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene
    • Ezzedine ZD, Martuza RL, Platika D, et al. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol 1991; 3: 608-14
    • (1991) New Biol , vol.3 , pp. 608-614
    • Ezzedine, Z.D.1    Martuza, R.L.2    Platika, D.3
  • 16
    • 0025444099 scopus 로고
    • Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene
    • Moolten FL, Wells JM, Heyman RA, et al. Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. Hum Gene Ther 1990; 1: 125-34
    • (1990) Hum Gene Ther , vol.1 , pp. 125-134
    • Moolten, F.L.1    Wells, J.M.2    Heyman, R.A.3
  • 17
    • 0021860994 scopus 로고
    • Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells
    • Smee DF, Boehme R, Chernow M, et al. Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells. Biochem Pharmacol 1985; 34: 1049-56
    • (1985) Biochem Pharmacol , vol.34 , pp. 1049-1056
    • Smee, D.F.1    Boehme, R.2    Chernow, M.3
  • 18
    • 0021055765 scopus 로고
    • Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes-simplex virus-infected cells
    • Cheng Y-C, Grill SP, Dutschman GE, et al. Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes-simplex virus-infected cells. J Biol Chem 1983; 258: 12460-4
    • (1983) J Biol Chem , vol.258 , pp. 12460-12464
    • Cheng, Y.-C.1    Grill, S.P.2    Dutschman, G.E.3
  • 19
    • 0021934346 scopus 로고
    • Activity of 9-[2-hydroxy-1-(hydroxy-methyl)ethoxymethyl]guanine in the treatment of cytomegalovirus pneumonia
    • Shepp DH, Dandliker PS, de Miranda P, et al. Activity of 9-[2-hydroxy-1-(hydroxy-methyl)ethoxymethyl]guanine in the treatment of cytomegalovirus pneumonia. Ann Int Med 1985; 103: 368-73
    • (1985) Ann Int Med , vol.103 , pp. 368-373
    • Shepp, D.H.1    Dandliker, P.S.2    De Miranda, P.3
  • 21
    • 0027312542 scopus 로고
    • Targeting of retroviral vectors for gene therapy
    • Salmons B, Gunzburg WH. Targeting of retroviral vectors for gene therapy. Hum Gene Ther 1993; 4: 129-41
    • (1993) Hum Gene Ther , vol.4 , pp. 129-141
    • Salmons, B.1    Gunzburg, W.H.2
  • 22
    • 0026641562 scopus 로고
    • Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer
    • Donahue RE, Kessler SW, Bodine D, et al. Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer. J Exp Med 1992; 176: 1125-35
    • (1992) J Exp Med , vol.176 , pp. 1125-1135
    • Donahue, R.E.1    Kessler, S.W.2    Bodine, D.3
  • 23
    • 0027531548 scopus 로고
    • In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats
    • Ram Z, Culver KW, Walbridge S, et al. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 1993; 53: 83-8
    • (1993) Cancer Res , vol.53 , pp. 83-88
    • Ram, Z.1    Culver, K.W.2    Walbridge, S.3
  • 24
    • 0027076349 scopus 로고
    • Retrovirus-mediated gene transfer targeted to malignant glioma cells in murine brain
    • Yamada M, Shimizu K, Miayo Y, et al. Retrovirus-mediated gene transfer targeted to malignant glioma cells in murine brain. Jpn J Cancer Res 1992; 83: 1244-7
    • (1992) Jpn J Cancer Res , vol.83 , pp. 1244-1247
    • Yamada, M.1    Shimizu, K.2    Miayo, Y.3
  • 25
    • 0025610750 scopus 로고
    • Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line
    • Short MP, Choi JK, Lee A, et al. Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neuroscience Res 1990; 27: 427-33
    • (1990) J Neuroscience Res , vol.27 , pp. 427-433
    • Short, M.P.1    Choi, J.K.2    Lee, A.3
  • 26
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector producer cells for treatment of experimental brain tumors
    • Culver KW, Ram Z, Walbridge S, et al. In vivo gene transfer with retroviral vector producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-2
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Walbridge, S.3
  • 27
    • 0027378976 scopus 로고
    • Thymidine kinase-mediated killing of rat brain tumors
    • Barba D, Hardin J, Ray J, et al. Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg 1993; 79: 729-35
    • (1993) J Neurosurg , vol.79 , pp. 729-735
    • Barba, D.1    Hardin, J.2    Ray, J.3
  • 28
    • 0028168775 scopus 로고
    • Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors: Cancer therapy strategy
    • Brody SL, Jaffe HA, Han SK, et al. Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors: cancer therapy strategy. Hum Gene Ther 1994; 5: 437-47
    • (1994) Hum Gene Ther , vol.5 , pp. 437-447
    • Brody, S.L.1    Jaffe, H.A.2    Han, S.K.3
  • 29
    • 0027408530 scopus 로고
    • Transfer of a foreign gene into the brain using adenovirus vectors
    • Akli S, Caillaud C, Vigne E, et al. Transfer of a foreign gene into the brain using adenovirus vectors. Nature Genet 1993; 3: 224-8
    • (1993) Nature Genet , vol.3 , pp. 224-228
    • Akli, S.1    Caillaud, C.2    Vigne, E.3
  • 30
    • 0027477148 scopus 로고
    • Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
    • Bajocchi G, Feldman SH, Crystal RG, et al. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nature Genet 1993; 3: 229-34
    • (1993) Nature Genet , vol.3 , pp. 229-234
    • Bajocchi, G.1    Feldman, S.H.2    Crystal, R.G.3
  • 31
    • 0027522920 scopus 로고
    • A model system for in vivo gene transfer into the central nervous system using an adenoviral vector
    • Davidson BL, Allen ED, Kozarsky KF, et al. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nature Genet 1993; 3: 219-23
    • (1993) Nature Genet , vol.3 , pp. 219-223
    • Davidson, B.L.1    Allen, E.D.2    Kozarsky, K.F.3
  • 32
    • 0027457561 scopus 로고
    • An adenovirus vector for gene transfer into neurons and glia in the brain
    • La Salle GL, Robert JJ, Berrard S, et al. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 1993; 259: 988-90
    • (1993) Science , vol.259 , pp. 988-990
    • La Salle, G.L.1    Robert, J.J.2    Berrard, S.3
  • 33
    • 0028348372 scopus 로고
    • Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: An effective in vitro drug sensitization system
    • Smythe WR, Hwang HC, Amin KM, et al. Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res 1994; 54: 2055-9
    • (1994) Cancer Res , vol.54 , pp. 2055-2059
    • Smythe, W.R.1    Hwang, H.C.2    Amin, K.M.3
  • 34
    • 0028919347 scopus 로고
    • Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo
    • Bonnekoh B, Greenhalgh DA, Bundham DS, et al. Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo. J Invest Dermatol 1995; 104: 313-7
    • (1995) J Invest Dermatol , vol.104 , pp. 313-317
    • Bonnekoh, B.1    Greenhalgh, D.A.2    Bundham, D.S.3
  • 35
    • 0027477387 scopus 로고
    • In vitro and in vivo targeting of gene expression to melanoma cells
    • Vile RG, Hart IR. In vitro and in vivo targeting of gene expression to melanoma cells. Cancer Res 1993; 53: 962-7
    • (1993) Cancer Res , vol.53 , pp. 962-967
    • Vile, R.G.1    Hart, I.R.2
  • 36
    • 0029062270 scopus 로고
    • Adenovirus gene transfer causes inflammation in the brain
    • Byrnes AP, Rusby JE, Wood MJA, et al. Adenovirus gene transfer causes inflammation in the brain. Neuroscience 1995; 66: 1015-24
    • (1995) Neuroscience , vol.66 , pp. 1015-1024
    • Byrnes, A.P.1    Rusby, J.E.2    Wood, M.J.A.3
  • 37
    • 0024318150 scopus 로고
    • Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate
    • Coen DM, Kosz-Vnenchak M, Jacobson JG, et al. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc Natl Acad Sci USA 1989; 86: 4736-40
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 4736-4740
    • Coen, D.M.1    Kosz-Vnenchak, M.2    Jacobson, J.G.3
  • 38
    • 0028034286 scopus 로고
    • Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
    • Boviatsis EJ, Park JS, Sena-Esteves M, et al. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res 1994; 54: 5745-51
    • (1994) Cancer Res , vol.54 , pp. 5745-5751
    • Boviatsis, E.J.1    Park, J.S.2    Sena-Esteves, M.3
  • 39
    • 0025864440 scopus 로고
    • Experimental therapy of human glioma by means of a genetically engineered virus mutant
    • Martuza RL, Malick A, Markert JM, et al. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science 1991; 252: 854-6
    • (1991) Science , vol.252 , pp. 854-856
    • Martuza, R.L.1    Malick, A.2    Markert, J.M.3
  • 40
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Ulmer JB, Donnelly JJ, Parker SE, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745-9
    • (1993) Science , vol.259 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.J.2    Parker, S.E.3
  • 41
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang D, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature 1992; 356: 152-4
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.1    DeVit, M.2    Johnston, S.A.3
  • 42
    • 0026902399 scopus 로고
    • Immunotherapy of malignancy by in vivo gene transfer into tumors
    • Nabel J, Chang A, Nabel EG, et al. Immunotherapy of malignancy by in vivo gene transfer into tumors. Hum Gene Ther 1992; 3: 399-410
    • (1992) Hum Gene Ther , vol.3 , pp. 399-410
    • Nabel, J.1    Chang, A.2    Nabel, E.G.3
  • 43
    • 0027313072 scopus 로고
    • Systemic gene expression after intravenous DNA delivery into adult mice
    • Zhu N, Liggitt D, Liu Y, et al. Systemic gene expression after intravenous DNA delivery into adult mice. Science 1993; 261: 209-11
    • (1993) Science , vol.261 , pp. 209-211
    • Zhu, N.1    Liggitt, D.2    Liu, Y.3
  • 44
    • 0027057702 scopus 로고
    • Cytotoxicity of human -interferon produced in human glioma cells transfected with its gene by means of liposomes
    • Yoshida J, Mizuno M, Yagi K. Cytotoxicity of human -interferon produced in human glioma cells transfected with its gene by means of liposomes. Biochem Intl 1992; 28: 1055-61
    • (1992) Biochem Intl , vol.28 , pp. 1055-1061
    • Yoshida, J.1    Mizuno, M.2    Yagi, K.3
  • 45
    • 0023212742 scopus 로고
    • Receptor-mediated in vitro gene transformation by a soluble DNA carrier system
    • Wu GY, Wu CH. Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J Biol Chem 1987; 262: 4429-32
    • (1987) J Biol Chem , vol.262 , pp. 4429-4432
    • Wu, G.Y.1    Wu, C.H.2
  • 46
    • 0025340966 scopus 로고
    • Transferrin-polycation conjugates as carriers for DNA uptake into cells
    • Wagner E, Zenke M, Cotten M, et al. Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc Natl Acad Sci USA 1990; 87: 3410-4
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3410-3414
    • Wagner, E.1    Zenke, M.2    Cotten, M.3
  • 47
    • 14744286188 scopus 로고
    • Particle bombardment-mediated gene transfer and expression in rat brain tissues
    • Jiao S, Cheng L, Wolff JA, et al. Particle bombardment-mediated gene transfer and expression in rat brain tissues. Biotechnology 1993; 11: 497-502
    • (1993) Biotechnology , vol.11 , pp. 497-502
    • Jiao, S.1    Cheng, L.2    Wolff, J.A.3
  • 48
    • 0027787053 scopus 로고
    • In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy
    • Bi WL, Parysek LM, Warnick R, et al. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum Gene Ther 1993; 4: 725-31
    • (1993) Hum Gene Ther , vol.4 , pp. 725-731
    • Bi, W.L.1    Parysek, L.M.2    Warnick, R.3
  • 49
    • 0028864786 scopus 로고
    • The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro
    • Fick J, Barker FGII, Dazin P, et al. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc Natl Acad Sci USA 1995; 92: 11071-5
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11071-11075
    • Fick, J.1    Barker, F.G.I.I.2    Dazin, P.3
  • 50
    • 0029913138 scopus 로고    scopus 로고
    • Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro
    • Elshami AA, Saavedra A, Zhang H, et al. Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Ther 1996; 3: 85-92
    • (1996) Gene Ther , vol.3 , pp. 85-92
    • Elshami, A.A.1    Saavedra, A.2    Zhang, H.3
  • 52
    • 0025780973 scopus 로고
    • Selective elimination of recombinant genes in vivo with a suicide retroviral vector
    • Plautz G, Nabel EG, Nabel GJ. Selective elimination of recombinant genes in vivo with a suicide retroviral vector. New Biol 1991; 7: 709-15
    • (1991) New Biol , vol.7 , pp. 709-715
    • Plautz, G.1    Nabel, E.G.2    Nabel, G.J.3
  • 53
    • 0028202066 scopus 로고
    • Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo
    • Chen S-H, Shine HD, Goodman JC, et al. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994; 91: 3054-7
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3054-3057
    • Chen, S.-H.1    Shine, H.D.2    Goodman, J.C.3
  • 54
    • 0027483695 scopus 로고
    • The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
    • Freeman SM, Abbou CN, Whartenby KA, et al. The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-83
    • (1993) Cancer Res , vol.53 , pp. 5274-5283
    • Freeman, S.M.1    Abbou, C.N.2    Whartenby, K.A.3
  • 55
    • 0028071271 scopus 로고
    • The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats
    • Ram Z, Walbridge S, Shawker T, et al. The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J Neurosurg 1994; 81: 256-60
    • (1994) J Neurosurg , vol.81 , pp. 256-260
    • Ram, Z.1    Walbridge, S.2    Shawker, T.3
  • 56
    • 0028001717 scopus 로고
    • Bystander tumoricidal effect in the treatment of experimental brain tumors
    • Wu JK, Cano WG, Meylaerts SAG, et al. Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 1994; 35: 1094-103
    • (1994) Neurosurgery , vol.35 , pp. 1094-1103
    • Wu, J.K.1    Cano, W.G.2    Meylaerts, S.A.G.3
  • 57
    • 0028674207 scopus 로고
    • Toxicity and immunologic effects of in vivo retrovirus-mediated gene transfer of the herpes simplex-thymidine kinase gene into solid tumors
    • Culver KW, Moorman DW, Muldoon RR, et al. Toxicity and immunologic effects of in vivo retrovirus-mediated gene transfer of the herpes simplex-thymidine kinase gene into solid tumors. Cold Spring Harb Symp on Quant Biol 1994; 59: 683-90
    • (1994) Cold Spring Harb Symp on Quant Biol , vol.59 , pp. 683-690
    • Culver, K.W.1    Moorman, D.W.2    Muldoon, R.R.3
  • 58
    • 0019382141 scopus 로고
    • The 9L rat brain tumor model: Description and application of the model
    • Weisacker M, Deen DF, Rosenblum ML, et al. The 9L rat brain tumor model: description and application of the model. J Neurol 1981; 224: 183-92
    • (1981) J Neurol , vol.224 , pp. 183-192
    • Weisacker, M.1    Deen, D.F.2    Rosenblum, M.L.3
  • 59
    • 0027317796 scopus 로고
    • Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors
    • Ram Z, Culver KW, Walbridge S, et al. Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors. J Neurosurg 1993; 79: 400-7
    • (1993) J Neurosurg , vol.79 , pp. 400-407
    • Ram, Z.1    Culver, K.W.2    Walbridge, S.3
  • 60
    • 0027548077 scopus 로고
    • A clinical protocol: Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • Oldfield EH, Ram Z, Culver KW, et al. A clinical protocol: gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 1993; 4: 39-69
    • (1993) Hum Gene Ther , vol.4 , pp. 39-69
    • Oldfield, E.H.1    Ram, Z.2    Culver, K.W.3
  • 61
    • 0028038843 scopus 로고
    • Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ ganciclovir system
    • Culver KW, Van Gilder J, Link Jr CJ, et al. Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ ganciclovir system. Hum Gene Ther 1993; 5: 343-77
    • (1993) Hum Gene Ther , vol.5 , pp. 343-377
    • Culver, K.W.1    Van Gilder, J.2    Link Jr., C.J.3
  • 62
    • 0028124751 scopus 로고
    • Gene therapy for the treatment of recurrent pediatric malignant astrocytomas using in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system
    • Raffel C, Culver KW, Kohn D, et al. Gene therapy for the treatment of recurrent pediatric malignant astrocytomas using in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum Gene Ther 1994; 5: 863-90
    • (1994) Hum Gene Ther , vol.5 , pp. 863-890
    • Raffel, C.1    Culver, K.W.2    Kohn, D.3
  • 63
    • 0029013431 scopus 로고
    • Intrathecal gene therapy for the treatment of leptomeningeal carcinomatosis: A phase I/II study
    • Oldfield EH, Ram Z, Chiang Y, et al. Intrathecal gene therapy for the treatment of leptomeningeal carcinomatosis: a phase I/II study. Hum Gene Ther 1995; 6: 55-85
    • (1995) Hum Gene Ther , vol.6 , pp. 55-85
    • Oldfield, E.H.1    Ram, Z.2    Chiang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.