Improved motor function of denervated rat hindlimb muscles induced by embryonic spinal cord grafts

European Journal of Neuroscience

Volumn 8, Issue 10, 1996, Pages 2198-2203

  Nógrádi, Antal ^a   Vrbová, Gerta ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Motoneuron; Rat; Regeneration; Reinnervation; Transplantation

Indexed keywords

BROXURIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LABELING; CELL TRANSPLANTATION; CONTROLLED STUDY; DENERVATION; EMBRYO; EMBRYO CELL; EXTENSOR DIGITORUM LONGUS MUSCLE; HINDLIMB; MOTONEURON; MOTOR PERFORMANCE; MUSCLE DENERVATION; MUSCLE FORCE; MUSCLE FUNCTION; MUSCLE TETANIC CONTRACTION; NERVE FIBER; NERVE FIBER REGENERATION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SPINAL CORD; TIBIALIS ANTERIOR MUSCLE; VENTRAL ROOT;

ANIMALS; AXONS; CELL DIVISION; DENERVATION; FETAL TISSUE TRANSPLANTATION; HINDLIMB; MOTOR NEURONS; MUSCLE, SKELETAL; NEURITES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL NERVE ROOTS;

EID: 0029957402     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1996.tb00741.x     Document Type: Article

References (16)

1. Andersen, D. K., Reier, P. J., Wirth, E. D., III, Theele, D. P. and Brown, S. A. (1991) Transplants of fetal grafts in chronic compression lesions of the adult cat spinal cord. Restor. Neural. Neurosci., 2, 309-325.
2. Bregman, B. S., Bernstein-Goral, H. and Kunkel-Bagden, E. (1991) CNS transplants promote anatomical plasticity and recovery of function after spinal cord injury. Restor. Neurol. Neurosci, 2, 327-338.
3. Carlstedt, T., Linda, H., Cullheim, S. and Risling, M. (1986) Reinnervation of hind limb muscles after ventral root avulsion and implantation in the lumbar spinal cord of the adult rat. Acta Physiol. Scand., 128, 645-646.
4. Carlstedt, T., Cullheim, S., Risling, M. and Ulfhake, B. (1988) Mammalian root-spinal cord regeneration. Prog. Brain Res., 78, 225-229.
5. Carlstedt, T., Grane, P., Hallin, R. G. and Norén, G. (1995) Return of function after spinal cord implantation of avulsed spinal nerve roots. Lancet, 346, 1323-1325.
6. Clowry, G. and Vrbová, G. (1992) Observations on the development of transplanted embryonic ventral hom neurones grafted into adult rat spinal cord and connected to skeletal muscle implants via a peripheral nerve. Exp. Brain Res., 91, 249-258.
7. Ernfors, P. and Persson, H. (I991) Developmentally regulated expression of HDNF/NT3 mRNA in rat spinal cord motoneurons and expression of BDNF mRNA in the embryonic dorsal root ganglion. Eur. J. Neurosci., 3,953-961.
8. Iwashita, Y., Kawaguchi, S. and Murata, M. (1994) Restoration of function by replacement of spinal cord segments in the rat. Nature, 367, 167-170.
9. Kunkel-Bagden, E. and Bregman, B. S. (1990) Spinal cord transplants enhance the recovery of locomotor function after spinal cord injury at birth. Exp. Brain Res., 81, 25-34.
10. Linda, H., Risling, M. and Cullheim, S. (1985) 'Dendraxons' in regenerating motoneurons in the cat: do dendrites generate new axons after central axotomy? Brain Res., 358, 329-333.
11. Nógrádi, A. and Vrbová, G. (1994) The use of embryonic spinal cord grafts to replace identified motoneurone pools depleted by a neurotoxic lectin, volkensin. Exp. Neurol., 129, 31-42.
12. Schwab, M. E. and Caroni, P. (1988) Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J. Neurosci., 8, 2381-2393.
13. Sieradzan, K. and Vrbová, G. (1989) Replacement of missing motoneurons by embryonic grafts in the rat spinal cord. Neuroscience, 31, 115-130.
14. Smith, K. J. and Kodama, R. T. (1991) Reinnervation of denervated skeletal muscle by central neurones regenerating via ventral roots implanted into the spinal cord. Brain Res., 551, 221-229.
15. Swett, J. E., Wikholm, R. P., Blanks, R. H. I., Swett, A. L. and Conley, L. C. (1986) Motoneurons of the rat sciatic nerve. Exp. Neurol., 93, 227-252.
16. Vejsada, R. and Hnik, P. (1980) Radicular innervation of hindlimb muscles of the rat. Physiol. Bohemoslov., 29, 385-392.