Muscarinic effects on action potential duration and its rate dependence in canine Purkinje fibers

PACE - Pacing and Clinical Electrophysiology

Volumn 19, Issue 11 II, 1996, Pages 2023-2026

  Malfatto, Gabriella ^a,d   Zaza, Antonio ^b   Vanoli, Emilio ^c   Schwartz, Peter J ^c  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d IRCCS   (Italy)

Author keywords

action potential duration; autonomic modulation

Indexed keywords

MUSCARINIC RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; DOG; ENDOCARDIUM; EPICARDIUM; FEMALE; HEART INNERVATION; HEART MUSCLE POTENTIAL; MALE; NONHUMAN; PURKINJE FIBER;

EID: 0029957195     PISSN: 01478389     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8159.1996.tb03274.x     Document Type: Article

References (21)

1. Schwartz PJ, Vanoli E, Stramba-Badiale M, et al. Autonomic mechanisms and sudden death: New insights from analysis of baroceptor reflexes in conscious dogs with and without a myocardial infarction. Circulation 1988; 78:969-973.
2. Vanoli E, De Ferrari G, Stramba-Badiale M, et al. Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. Circ Res 1991; 68:1471-1481.
3. Kleiger RE, Miller JP, Bigger JT, et al. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987; 59:256-262.
4. La Rovere MT, Specchia G, Mortara A, et al. Baroreflex sensitivity, clinical correlates and cardiovascular mortality among patients with a first myocardial infarction: A prospective study. Circulation 1988; 78:816-824.
5. Levy MN. Sympathetic-parasympathetic interactions in the heart. Circ Res 1971; 29:437-445.
6. Bailey JC, Watanabe AM, Besch HR, et al. Acetylcholine antagonism of the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers. Circ Res 1979; 44:378-383.
7. Rardon DP, Bailey JC. Direct effects of cholinergic stimulation on ventricular automaticity in guinea pig myocardium. Circ Res 1983; 52:105-110.
8. Litovsky SH, Antzelevitch C. Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. Circ Res 1990; 67: 615-627.
9. Malfatto G, Zaza A, Schwartz PJ: Parasympathetic control of cycle length dependence of endocardial ventricular repolarisation in the intact feline heart under steady state conditions. Cardiovasc Res 1993; 27:823-827.
10. Gadsby DC, Wit AL, Cranefield PF. The effects of acetylcholine on the electrical activity of canine cardiac Purkinje fibers. Circ Res 1978; 43:29-35.
11. The Task Force of the Working Group on Arrhythmias of the European Society of Cardiology: The Sicilian Gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Eur Heart J 1991; 12:1112-1131.
12. + channel blockers and muscarinic receptor stimulation. J Pharmacol Exp Ther 1995; 273:1095-1104.
13. Fleming JW, Hodges TD, Watanabe AM. Pertussis toxin treated dog: A whole animal model of impaired inhibitory regulation of adenylate cyclase. Circ Res 1988; 62:992-1000.
14. Zaza A, Malfatto G, Schwartz PJ. Sympathetic modulation of the relation between ventricular repolarization and cycle length. Circ Res 1991; 68: 1191-2003.
15. Rosen MR, Hoffman BF. The vagus and the ventricle. (editorial) Circ Res 1978; 42:1.
16. Higgins CB, Vatner SF, Braunwald E. Parasympathetic control of the heart. Pharmacol Rev 1973: 25:119-155.
17. Sorota S, Pappano AJ. Muscarinic receptor-effector coupling in the heart. In MR Rosen, MJ Janse, AL Wit (eds.): Cardiac Electrophysiology: A Textbook. Mount Kisco, NY, Futura Publishing Company, Inc., 1990, pp. 803-817.
18. Sato R, Hisatone I, Wasserstrom JA, et al. Acetylcholine sensitive potassium channels in human atrial myocytes. Am J Physiol 1990; 259: H1730-H1735.
19. Boyett MR, Kirby MS, Orchard CH, et al. The negative inotropic effect of acetylcholine on ferret ventricular myocardium. J Physiol 1988; 404: 613-635.
20. + channels in mammalian ventricular myocytes. Am J Physiol 1994; 266:H1812-H1821.
21. Rosenshtraukh L, Danilo P, Anyukhovsky EP, et al. Mechanisms for vagal modulation of ventricular repolarization and of coronary occlusion induced lethal arrhythmias in cats. Circ Res 1994; 75:722-732.