Partitioned association-linkage test: Distinguishing 'necessary' from 'susceptibility' loci

Genetic Epidemiology

Volumn 13, Issue 3, 1996, Pages 243-252

  Greenberg, David A ^a   Doneshka, Paolina ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

association analysis; disease etiology; disease marker association; heterogeneity; linkage analysis

Indexed keywords

ARTICLE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE EXPRESSION REGULATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC MARKER; GENETIC SUSCEPTIBILITY; MATHEMATICAL COMPUTING; POPULATION MODEL;

ALLELES; CHROMOSOME MAPPING; COMPUTER SIMULATION; DISEASE SUSCEPTIBILITY; GENETIC DISEASES, INBORN; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; LOD SCORE; MUTATION;

EID: 0029957150     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1996)13:3<243::AID-GEPI2>3.0.CO;2-7     Document Type: Article

References (7)

1. Cavalli-Sforza LL, Bodmer WF (1971): "The Genetics of Human Populations." San Francisco: WH Freeman, pp 310-313.
2. Durner M, Greenberg DA, Hodge, SE (1996): Phenocopies vs. Genetic Heterogeneity: Can We Use Phenocopy Frequencies in Linkage Analysis to Compensate for Heterogeneity? Hum Hered (in press).
3. Greenberg DA (1989): Inferring mode of inheritance by comparison of lod scores. Am J Med Genet 34:480-486.
4. Greenberg DA (1993): Linkage analysis of "necessary" loci vs "susceptibility" loci. Am J Hum Genet 52:135-143.
5. Hodge SE (1993): Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations. Am J Hum Genet 53:367-384.
6. Hodge SE, Elston RC (1994): Lods, wrods, and mods: the interpretation of lod scores calculated under different models. Genet Epidemiol 11:329-342.
7. Morton NE (1955): Sequential tests for the detection of linkage. Am J Hum Genet 7:277-318.