Transfected Saos-2 cells overexpressing phosphoinositidase C β1 isoform accumulate it within the nucleus

Biology of the Cell

Volumn 86, Issue 2-3, 1996, Pages 121-126

  Marmiroli, Sandra ^a   Zini, Nicoletta ^a   Bavelloni, Alberto ^b   Faenza, Irene ^a   Ognibene, Andrea ^b   Maraldi, Nadir M ^a,b  

^a CNR   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Cell transfection; Immunocytochemistry; Osteosarcoma Saos 2 cells; Phosphoinositidase C 1; Signal transduction

Indexed keywords

COMPLEMENTARY DNA; ISOENZYME; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE;

ARTICLE; CELL NUCLEUS; CYTOPLASM; ELECTRON MICROSCOPE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; OSTEOSARCOMA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

SUS SCROFA;

EID: 0029956827     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1016/0248-4900(96)84774-5     Document Type: Article

References (23)

1. 1 Banfic H, Zizak M, Divecha N, Irvine RF (1993) Nuclear diacylglycerol is increased during cell proliferation in vivo. Biochem J 290, 633-636
2. 2 Capitani S, Bertagnolo V, Mazzoni M, Santi P, Previati M, Antonucci A, Manzoli FA (1989) Lipid phosphorylation in isolated rat liver nuclei. Synthesis of polyphosphoinositides at subnuclear level. FEBS Lett 254, 194-198
3. 3 Cocco L, Gilmour RS, Ognibene A, Letcher AJ, Manzoli FA, Irvine RF (1987) Synthesis of polyphosphoinositides in nuclei of Friend cell. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J 248, 765-770
4. 4 Cocco L, Martelli AM, Gilmour RS, Ognibene A, Manzoli FA, Irvine RF (1989) Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I. Biochem Biophys Res Commun 159, 720-725
5. 5 Divecha N, Banfic H, Irvine RF (1991) The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane and stimulation of the cycle increases nuclear diacylglicerol and apparently induces translocations of protein kinase C to the nucleus. EMBO J 10, 3207-3214
6. 1 is specifically, but not predominantly, located in the nucleus. Biochem J 289, 617-620
7. 7 Irvine RF, Divecha N (1992) Phospholipids in the nucleus. Metabolism and possible functions. Seminars Cell Biol 3, 225-235
8. 8 Maraldi NM, Zini N, Squarzoni S, Del Coco R, Sabatelli P, Manzoli FA (1992) Intranuclear localization of phospholipids by ultrastructural cytochemistry. J Histochem Cytochem 40, 1383-1392
9. 9 Maraldi NM, Zini N, Santi S, Bavelloni A, Valmori A, Marmiroli S, Ognibene A (1993) Phosphoinositidase C isozymes in Saos-2 cells: immunocytochemical detection in nuclear and cytoplasmic compartments. Biol Cell 79, 243-250
10. 1 in cells exposed to mitogenic or differentiating agonists. Biol Cell 83, 201-210
11. 11 Margolis B, Zilberstein A, Franks C, Felder C, Kremer S, Ullrich A, Rhee SG, Skorecki K, Schlessinger J (1990) Effect of phospholipase C-γ overexpression on PDGF-induced second messengers and mitogenesis. Science 248, 607-610
12. 12 Marmiroli S, Ognibene A, Bavelloni A, Cinti C, Cocco L, Maraldi NM (1994) Interleukin 1α stimulated nuclear phosphoinositidase C in human osteosarcoma Saos-2 cells. J Biol Chem 269, 13-16
13. 13 Martelli AM, Billi AM, Gilmour RS, Neri LM, Manzoli L, Ognibene A, Cocco L (1994) Phosphoinositide signalling in nuclei of Friend cells: phospholipase C β down-regulation is related to cell differentiation. Cancer Res 54, 2536-2540
14. 14 Martelli AM, Gilmour RS, Neri LM, Manzoli L, Corps AN, Cocco L (1991) Mitogen-stimulated events in nuclei of Swiss 3T3 cells. Evidence for a direct link between changes of inositol lipids, protein Kinase C requirement and the onset of DNA synthesis. FEBS Lett 283, 243-246
15. 15 Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L, Manzoli FA, Cocco L (1992) Nuclear localization and signalling activity of phosphoinositidase C β in Swiss 3T3 cells. Nature 358, 242-245
16. 16 Mazzotti G, Zini N, Rizzi E, Rizzoli R, Galanzi A, Ognibene A, Santi S, Matteucci A, Martelli AM, Maraldi NM (1995) Immunocytochemical detection of phosphatidylinositol 4,5-bisphosphate localization sites within the nucleus. J Histochem Cytochem 43, 181-191
17. 17 Michell RH (1992) Nuclear PIPs. Curr Biol 2, 200-202
18. 18 Payrastre B, Nievers M, Boonstra J, Breton M, Verkeleij AJ, van Bergen en Henegouwen PMP (1992) A differential localization of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix. J Biol Chem 267, 5078-5084
19. 19 Smith CD, Wells WW (1983) Phosphorylation of rat liver nuclear envelopes, characterization of in vitro phosphorylation. J Biol Chem 258, 9368-9373
20. 20 Suh PG, Rhy SH, Choi WC, Lee KY, Rhee SG (1988) Monoclonal antibodies to three phospholipase C isozymes from bovine brain. J Biol Chem 263, 14497-14504
21. 21 Zini N, Martelli AM, Cocco L, Manzoli FA, Maraldi NM (1993) Phosphoinositidase C isoforms are specifically localized in the nuclear matrix and cytoskeleton of Swiss 3T3 cells. Exp Cell Res 280, 257-269
22. 1 decreases following cell differentiation in Friend cells, whereas γ1 isoform is not affected. Eur J Cell Biol 68, 226-239
23. 1 in human osteosarcoma Saos-2 cells. Histochem J, in press