Serum N-terminal osteocalcin is a good indicator for estimating responders to hormone replacement therapy in postmenopausal women

Journal of Bone and Mineral Research

Volumn 11, Issue 11, 1996, Pages 1784-1792

  Chen, Jui Tung ^a   Hosoda, Kenji ^b   Hasumi, Katsuhiko ^a   Ogata, Etsuro ^a   Shiraki, Masataka ^c  

^a CANCER INSTITUTE HOSPITAL   (Japan)

^b TEIJIN LTD   (Japan)

^c Res Inst Pract Involutional Dis   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN; MEDROXYPROGESTERONE; OSTEOCALCIN;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE SUBSTITUTION; HUMAN; POSTMENOPAUSE OSTEOPOROSIS; PREDICTION; TREATMENT OUTCOME;

EID: 0029956755     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650111123     Document Type: Article

References (35)

1. Heaney RP, Recker RR, Saville PD 1978 Menopausal changes in bone remodeling. J Lab Clin Med 92:964-970.
2. Heaney RP, Recker RR, Saville PD 1978 Menopausal changes in calcium balance performance. J Lab Clin Med 92:953-963.
3. Steinche T, Hasling C, Charles P, Eriksen EF, Mosekilde L, melsen F 1989 A randomized study on the effects of estrogen/ gestagen or high dose oral calcium on trabecular bone remodeling in postmenopausal osteoporosis. Bone 10:313-320.
4. Richelson LS, Wahner HW, Melton LJ, Riggs BL 1984 Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. New Engl J Med 311:1273-1275.
5. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC 1976 Long-term prevention of postmenopausal osteoporosis by oestrogen. Lancet 1:1038-1041.
6. Riis BJ 1993 Biochemical markers of bone turnover II: Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 95 (Suppl 5A):17S-21S.
7. Stepan JJ, Pospichal J, Presl J, Pacovsky V 1987 Bone loss and biochemical indicies of bone remodeling in surgically induced postmenopausal women. Bone 8:279-284.
8. Civitelli R, Gonnelli S, Zecchei F, Bigazzi S, Vattimo A, Avioli LV, Gennari C 1988 Bone turnover in postmenopausal osteoporosis: Effect of calcitonin treatment. J Clin Invest 82:1268-1274.
9. Uebelhart D, Gineyts E, Chapuy M-C, Delmas PD 1990 Urinary excretion of pyridinium crosslinks: A new marker of bone resorption in metabolic bone disease. Bone Miner 8:87-96.
10. Prince PA, Pathemore JG, Deftoas LJ 1980 New biochemical marker for bone metabolism. J Clin Invest 66:878-883.
11. Brown JP, Delmas PD, Malaval L, Meunier PJ 1984 Serum bone Gla-protein: A specific marker for bone formation in postmenopausal osteoporosis. Lancet 1:1091-1093.
12. Taylor AK, Linkart S, Mohan S, Chrinstenson RA, Singer FR, Baylink D 1990 Multiple osteocalcin fragments in human urine and serum as detected by a midmolecule osteocalcin radioimmunoassay. J Clin Endocrinol Metab 70:467-472.
13. Tracy RP, Andrianovo A, Riggs BL, Mann KG 1990 Comparison of monoclonal and polyclonal antibody-based osteocalcin: A study of sources of variation in assay results. J Bone Miner Res 5:451-461.
14. Gundberg CM, Weinstein RS 1986 Multiple immunoreactive forms of osteocalcin in uremic serum. J Clin Invest 77:1762-1767.
15. Garnero P, Grimaux M, Seguin P, Delmas PD 1994 Characterization of immunoreaction forms of human osteocalcin generated in vivo and in vitro. J Bone Miner Res 9:255-264.
16. Hosoda H, Eguchi H, Nakamoto T, Kubota T, Honda H, Jindai S, Hasegawa R, Kiyoki M, Yamaji T, Shiraki M 1991 Sandwich immunoassay for intact human osteocalcin. Clin Chem 38:2233-2238.
17. Eguchi H, Hosoda K, Kurihara N, Nakamoto T, Kobayashi S, Arita M, Hasegawa R, Ohta T, Kiyoki M, Yamaji T, Shiraki M 1995 Sandwich immunoassay specific for the N-terminal sequence of osteocalcin. J Immunol Meth 184:231-240.
18. Kohler G, Milstein C 1975 Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497.
19. Hosoda K, Sakurabayashi I, Kawai T, Suzuki H, Maeda M, Tsuji A 1985 Quantitative immunoassay for IgA class circulation immune complexes using solid phase Facb fragment of anti-C3. J Immunol Meth 82:243-252.
20. Houghten RA 1985 General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids. Proc Natl Acad Sci USA 82:5131-5135.
21. Price PA, Williamson MK, Lothringer JW 1981 Origin of vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone. J Biol Chem 256:12760-12766.
22. Farley JR, Chesnut CJ, Bayling DJ 1981 Improved method for quantitative determination in serum alkaline phosphatase of skeletal origin. Clin Chem 27:2002-2007.
23. Eyre DR, Dickson IR, van Ness KP 1987 Collagen cross-linking amino acids. Meth Enzymol 144:115-139.
24. Eyre DR, Dickson IR, van Ness KP 1988 Collagen cross-linking in human bone and articular cartridge. Age-related changes in the content of mature hydroxypyridinium residues. Biochem J 252:495-500.
25. Prockop OJ, Kivirikko KI, Tudermen K 1979 The biosynthesis of collagen and its disorders. New Engl J Med 301:13-23.
26. Smith RD, Loo JA, Edmonds CG, Barinaga CJ, Udseth HR 1990 New developments in biochemical mass spectrometry: Electrospray ionization. Anal Chem 62:882-899.
27. Johansen JS, Riis BJ, Delmas PD, Christiansen C 1988 Plasma BGP: An indicator of spontaneous bone loss and of the effect of oestrogen treatment in postmenopausal women. Eur J Clin Invest 18:191-195,
28. Riis BJ, Overgaard K, Christiansen C 1995 Biochemical markers of bone turnover to monitor the bone response to postmenopausal hormone replacement therapy. Osteoporosis Int 5:276-280.
29. Filipponi P, Pedetti M, Fedeli L, Cini L, Palumbo R, Boldrini S, Massoni C, Cristallini S 1995 Cyclical clodronate is effective in preventing postmenopausal bone loss: A comparative study with transcutaneous hormone replacement therapy. J Bone Miner Res 10:697-703.
30. Wronsky TJ, Clintron M, Doherty AL, Dann LM 1988 Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123:681-686.
31. Bain SD, Bailey MC, Celino DL, Lantry MM, Edwards MW 1993 High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse. J Bone Miner Res 8:435-442.
32. Uebelhart D, Schlemmer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD 1991 Effect of menopause and estrogen treatment on the urinary excretion of pyridinium crosslinks. J Clin Endocrinol Metab 66:88-92.
33. Garnero P, Shin WJ, Gineyts E, Karpf DB, Delmas PD 1994 Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 79:1693-1700.
34. Garnero P, Gineyts E, Arbault P, Christiansen C, Delmas PD 1995 Different effects of bisphosphonate and estrogen therapy on free and peptide-bound bone cross-links excretion. J Bone Miner Res 10:641-649.
35. Parviainen M, Kuronen I, Kokko H, Lakaniemi M, Savolainen K, Mononen I 1994 Two-site enzyme immunoassay for measuring intact human osteocalcin in serum. J Bone Miner Res 9:347-354.