Increased release of the tumour necrosis factor receptor p75 by immortalized human keratinocytes results from an activated shedding mechanism and is not related to augmented steady-state levels of p75 mRNA

Archives of Dermatological Research

Volumn 288, Issue 11, 1996, Pages 691-696

  Neuner, Peter ^a   Pourmojib, Mojgan ^a   Klosner, Gabriele ^a   Trautinger, Franz ^a   Knobler, Robert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Factor receptor; Keratinocytes; p75; Shedding; Tumour necrosis

Indexed keywords

MEMBRANE PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; CELL CULTURE; CELL IMMORTALIZATION; CELL MEMBRANE; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN SECRETION; SKIN DEFECT; SQUAMOUS CELL CARCINOMA;

EID: 0029956385     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02505279     Document Type: Article

References (25)

1. Schuger L, Dixit VM, Carey TE, Varani J (1990) Modulation of squamous carcinoma cell growth, morphology, adhesiveness and extracellular matrix production by interferon-γ and tumour necrosis factor-α. Pathobiology 58:279-286
2. Erickson SL, Sauvage FJ, Kikly Ch, Carver-Moore K, Pitts-Meek S, Gillet N, Sheehan KCF, Schreiber RD, Goeddel DV, Moore MW (1994) Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature 372:560
3. Brouckaert P, Libert C, Everaerdt B, Fiers W (1992) Selective species specificity of tumour necrosis factor for toxicity in the mouse. Lymphokine Cytokine Res 11:193-196
4. Aderka D, Wysenbeek A, Engelmann H, Cope AP, Brennan F, Molad Y, Hornik V, Levo Y, Maini RN, Feldmann M, Wallach D (1993) Correlation between serum levels of soluble tumour necrosis factor receptor and disease activity in systemic lupus erythematosus. Arthritis Rheum 36:1111-1120
5. Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF (1992) Tumour necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumour necrosis factor a in vitro and in vivo. Proc Natl Acad Sci USA 89:4845
6. Heilig B, Wermann M, Gallati, H, Brockhaus M, Berke B, Egen O, Pezzuto A, Hunstein W (1992) Elevated TNF receptor plasma concentrations in patients with rheumatoid arthritis Clin Invest 70:22-27
7. Belldegrun A, Pierce W, Sayah D, deKernion J, Wallach D, Aderka D, Figlin RA (1993) Soluble tumour necrosis factor receptor expression in patients with metastatic renal cell carcinoma treated with interleukin2-based immunotherapy. J Immunother 13:175-180
8. Gatanaga T, Hwang CD, Kohr W, Cappuccini F, Lucci JA, Jeffes EW, Lentz R, Tomich J, Yamamoto RS, Granger GA (1990) Purification and characterization of an inhibitor (soluble tumour necrosis factor receptor) for tumour necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients. Proc Natl Acad Sci USA 87:8781-8784
9. Aderka D, Engelmann H, Hornik V, Skornick Y, Levo Y, Wallach D, Kushtai G. (1991) Increased serum levels of soluble receptors for tumour necrosis factor in patients. Cancer Res 51:5602-5607
10. Grosen EA, Granger GA, Gatanaga M, Ininns EK, Hwang C, DiSaia P, Berman M., Manetta A, Emma D, Gatanaga T (1993) Measurement of the soluble membrane receptors for tumour necrosis factor and lymphotoxin in the sera of patients with gynecologic malignancy. Gynecol Oncol 50:68-77
11. Digel W, Porzsolt F, Schmid M, Herrmann F, Lesslauer W, Brockhaus M (1992) High levels of circulating soluble receptors for tumour necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia. J Clin Invest 89:1690-1693
12. Benelmans MHA, Abramovicz D, Gouma DJ, Goldmann M, Buurmann WA (1994) In vivo T cell activation by anti-CD3 monoclonal antibody induces soluble TNF receptor release in mice. Effects of pentoxifylline, methylprednisolone, anti-TNF, and anti-IFN-γ antibodies. J Immunol 153:499
13. Upton C, Macen JL, Schreiber M, McFadden G (1991) Myxoma virus expresses a secreted protein with homology to the tumour necrosis factor receptor gene family that contributes to viral virulence. Virology 184:370-382
14. Neuner P, Klosner G, Pourmojib M, Trautinger F, Knobler R (1994) Selective release of tumour necrosis factor binding protein II by malignant human epidermal cells reveals protection from tumour necrosis factor alpha mediated cytotoxicity. Cancer Res 54:6001-6005
15. Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM (1989) Binding and biological effects of tumour necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J Clin Invest 83:816-821
16. Old LJ (1987) Tumour necrosis factor. Polypeptide mediator network. Nature 326:330
17. Trefzer U, Brockhaus M, Lotscher H, Parlow F, Budnik A, Grewe M, Christoph H, Kapp A, Schöpf E, Luger TA, Krutmann J (1993) The 55-kD tumour necrosis factor receptor on human keratinocytes is regulated by tumour necrosis factor-alpha and by ultraviolet B radiation. J Clin Invest 92:462-470
18. Kirnbauer R, Köck A, Schwarz T, Urbanski A, Krutmann J, Borth W, Damm D, Shipley G, Ansel JC, Luger TA (1989) IFN-β2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J Immunol 142:1922-1928
19. Trefzer U, Brockhaus M, Loetscher H, Parlow F, Kapp A, Schöpf E, Krutmann J (1991) 55-kD tumour necrosis factor receptor is expressed by human keratinocytes and plays a pivotal role in regulation of human keratinocyte ICAM-1 expression. J Invest Dermatol 97:911-916
20. Björnberg F. Lantz N, Olsson I, Gullberg U (1994) Mechanisms involved in the processing of the p55 and the p75 tumour necrosis factor (TNF) receptors to soluble receptor forms. Lymphokine Cytokine Res 13:203-211
21. Nophar Y, Kemper O, Brakebusch C, Englemann H, Zwang R, Aderka D, Holtmann H, Wallach D (1990) Soluble forms of tumour necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor. EMBO J 9:3269-3278
22. Heller RA, Song K, Onasch MA, Fischer, WH, Chang D, Ringold GM (1990) Complementery DNA cloning of a receptor for tumour necrosis factor and demonstration of a shed form of the receptor. Proc Natl Acad Sci USA 87:6151-6155
23. Lantz N, Gullberg U, Nilsson E, Olsson I (1990) Characterization in vitro of a human tumour necrosis factor-binding protein. A soluble form of a tumour necrosis factor receptor. J Clin Invest 86:1396-1402
24. Kohno T, Brewer MT, Baker SL, Schwartz, PE, King MW, Hale KK, Squires CH, Thompson RC, Vannice JL (1990) A second tumour necrosis factor receptor gene product can shed a naturally occurring tumour necrosis factor inhibitor. Proc Natl Acad Sci USA 87:8331-8335
25. Crowe PK, Van Arsdale TL, Goodwin RG, Ware CF (1993) Specific induction of 80-kDa tumour necrosis factor receptor shedding in T lymphocytes involves the cytoplasmic domain and phosphorylation. J Immunol 151:6882-6890