Utilization of the rat as a model of mammalian aging: Impact of pathology on behavior

Gerontology

Volumn 42, Issue 6, 1996, Pages 301-311

  Spangler, Edward L ^a   Ingram, Donald K ^a  

^a JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

Hematology; Learning; Morbidity; Rodent

Indexed keywords

CANCER ANTIBODY;

AGED; AGING; ANIMAL MODEL; ANIMAL TISSUE; AUTOPSY; BEHAVIOR; HEMATOCRIT; KIDNEY DISEASE; LEUKEMIA; MALE; NONHUMAN; PATHOLOGY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RAT; REVIEW; SENDAI VIRUS;

EID: 0029955986     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000213808     Document Type: Article

References (38)

1. Masoro HJ: The role of animal models in meeting the gérontologie challenge of the 21st century. Gerontologist 1992;32:627-633.
2. Constant-Astrom B: Aging and Spatial Memory: Assessment of Age-Related Alterations of Spatial Memory in Rats; dissertation Université de Lausanne. 1994.
3. Hazzard DG, Warner HR, Finch CE: National Institute on Aging. NIH workshop on alternative animal models for research on aging. Exp Gerontol 1991;26:411-439.
4. Weindruch R: Animal models: in Masoro El (ed): Handbook of Physiology. Section 11: Aging. New York. Oxford University Press, 1995. pp 37-52.
5. Hazard DG, Bronson RT, McClearn GE, Strong R: Selection of an appropriate animal model to study aging processes with special emphasis on the use of rat strains. J Gerontol 1992;47:B63-B64.
6. Cheal MJ: The gerbil: A unique model for research on aging. Exp Aging Res 1986;12:3-21.
7. Weindruch R, Masoro EJ: Guest editorial: Concerns about rodent models for aging research. J Gerontol 1991;46:B87-B88.
8. Bronson RT, Lipman RD: The role of pathology in rodent experimental gerontology. Aging Clin Exp Res 1993:5:253-257.
9. Lipman RD, Chrisp CE, Hazzard DG, Bronson RT: Pathologic characterization of Brown Norway. Brown Norway X. Fischer 344 and Fischer 344 x Brown Norway rats with relation to age. J Gerontol 1996:51A:B54-B59.
10. Bronson RT: Rate of occurrence of lesions in 20 inbred and hybrid genotypes of rats and mice sacrificed at 6 months intervals during the first years of life: in Harrison DE (ed): Genetic Effects on Aging II. Caldwell. Telford Press, 1990. pp279-358.
11. Smith D, Bronson K: Clinical chemistry and hematology profiles of the aging rat. Lab Anim 1992:21:32-45.
12. Phelan J P, Austad SN: Selecting animal models of human aging: Inbred strains often exhibit less biological uniformity than F1 hybrids. J Gerontol 1994:49: B1-B11.
13. Spangler EL, Waggic KS, Henge-mihle J, Roberts D, Hess B, Ingram DK: Behavioral assessment of aging in male Fischer 344 and Brown Norway rat strains and their F hybrid. Neurobiol Aging 1994;15:319-328.
14. Weiss C, Thompson RF: Delayed acquisition of eyeblink conditioning in aged Fi hybrid (Fischer-344 x Brown Norway) rats. Neurobiol Aging 1992;13:319-323.
15. Baker H, Franzen L, Stone D, Cho JY, Margolis FL: Expression of tyrosine hydroxylase in the aging, rodent olfactory system. Neurobiol Aging 1995;16:119-128.
16. Burwell RD, Lawler CP, Gallagher M: Mcsostriatal dopamine markers in aged Long-Evans rats with sensorimotor impairment. Neurobiol Aging 1995;16:175-186.
17. Zyzak DR, Otto T, Eichenbaum H, Gallagher M: Cognitive decline associated with normal aging in rats: A neuropsychological approach. Learning Mem 1995:2:1-16.
18. Spangler EL, Waggie KS, Rea W, Roberts D, Hengemihlc J, Danon D, Ingram DK: Relationship of hematological variables to learning performance in aged Fischer-344 rats. Neurobiol Aging 1995:16:85-89.
19. Ingram DK: Analysis of age-related learning and memory impairments in rodent models. Ann NY Acad Sci 1985:444:312-331.
20. Ingram DK: Complex maze learning in rodents as a model of age-related memory impairment. Neurobiol Aging 1988;9:475-485.
21. Ingram D, Spangler E, Freeman J, Richard W: Age differences in performance of rats and mice in a 14-unit T-maze. Soc Neurosci Abstr 1984:10:452.
22. Spangler EL, Rigby P, Ingram DK: Scopolamine impairs learning performance of rats in a 14-unit T-maze. Pharmacol Biochcm Behav 1986;25:673-679.
23. Goodrich CL: Learning, retention, and extinction of a complex maze habit for mature-young and senescent Wistar albino rats. J Gerontol 1968:23:298-304.
24. Goodrick CL: Maze learning of mature-young and aged rats as a function of distribution of practice. J Exp Psychol 1973:98:344-349.
25. Roth GS, Brennecke LH, French AW, Williams NG, Waggie KS, Spurgeon HA, Ingram DK: Pathological characterization of male Wistar rats from the Gerontology Research Center. J Gerontol 1993:48: B213-B230.
26. Markowska AL, Ingram DK, Barnes CA, Spangler EL, Lemken VJ, Ka-metani H, Yee W, Olton DS: Acetvl-1-camitinc. 1: Effects on mortality, pathology and sensory motor performance in aging rats. Neurobiol Aging 1990:11:491-498.
27. Strombcrg PC: Changes in the hematologic system: in Mohr U. Dungworth DL. Capen CC (eds): Pathobiology of the aging rat. Washington, ILSI Press, 1992. vol 1.
28. Ingram DK: Toward the behavioral assessment of biological aging in the laboratory mouse: Concepts, terminology. and objectives. Exp Aging Res 1983:9:225-238.
29. Sarter M, Hagan J, Dudchenko P: Behavioral screening for cognition enhancers: From indiscriminate to valid testing. Part 1. Psychopharma-cologv 1992:107:144-159.
30. Fozard JL, Metter EJ, Brant LJ: Next steps in describing aging and disease in longitudinal studies. J Gerontol 1990:45:116-127.
31. Burwell RD, Whcalin J, Gallagher M: Effects of aging in the diurnal pattern of water intake in rats. Behav Neural Biol 1992:58:196-203.
32. Rogers J: Summary and recommendations of the Venice Conference on animal models for aging research. Neurobiol Aging 1991:12:699-701.
33. Shintokawa I, Migami Y, Hubbard GB, McMahan CA, Masoroa EJ, Yu BP: Diet and suitability of the male Fischer 344 rat as a model for aging research. J Gerontol 1993:48:B27- B32.
34. Shimokawa I, Yu B, Higami Y, Ike-da T, Masoro EJ: Dietary restriction retards onset but not progression of leukemia in male F344 rats. J Gerontol 1993:48:B68-B73.
35. Masoro EJ: Dietary restriction and aging. J Am Geriatr Soc 1993:41: 994-999.
36. Maeda H, Gleiser CA, Masoro EJ, Murata I, McMahan CA, Yu BP: Nutritional influences on aging of Fischer 344 rats: II: Pathology. J Gerontol 1985;40:671-688.
37. Higami Y, Yu BP, Shimokawa I, Masoro EJ, Ikeda T: Duration of dietary restriction: An important determinant for the incidence and age of onset of leukemia in male F344 rats. J Gerontol 1994:49:B239-B244.
38. Hazzard DG: Information Notice to Recipients of NIA Aged Mice and Rats. Bethesda. NIA. NIH. BAP. 1993.