Role of the Bordetella pertussis P.69/pertactin protein and the P.69/pertactin RGD motif in the adherence to and invasion of mammalian cells

Microbiology

Volumn 142, Issue 11, 1996, Pages 3261-3268

  Everest, Paul ^a   Li, Jingli ^b   Douce, Gillian ^a   Charles, Ian ^c   De Azavedo, Joyce ^c,e   Chatfield, Steven ^b   Dougan, Gordon ^a   Roberts, Mark ^d  

^a Vaccine Research Unit   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c WELLCOME RESEARCH LABORATORIES   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Adhesion; Bordetella pertussis; Invasion; Pertactin; RGD motif

Indexed keywords

BACTERIAL PROTEIN; CELL SURFACE PROTEIN; CYCLOHEXIMIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BACTERIUM ADHERENCE; BORDETELLA PERTUSSIS; CELL INTERACTION; CELL INVASION; CHO CELL; CONTROLLED STUDY; ESCHERICHIA COLI; MOLECULAR CLONING; NONHUMAN; PLASMID; PRIORITY JOURNAL; SALMONELLA; SALMONELLA TYPHIMURIUM; SITE DIRECTED MUTAGENESIS;

ANIMALIA; BACTERIA (MICROORGANISMS); BORDETELLA PERTUSSIS; CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA; ESCHERICHIA COLI K12; EUKARYOTA; MAMMALIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0029955778     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/13500872-142-11-3261     Document Type: Article

References (34)

1. Anderson, R., Dougan, G. & Roberts, M. (1996). Delivery of the pertactin/P.69 polypeptide of Bordetella pertussis using an attenuated Salmonella typhimurium vaccine strain: expression levels and immune response. Vaccine (in press).
2. Arico, B., Nuti, S., Scarlato, V. & Rappuoli, R. (1993). Adhesion of Bordetella pertussis to eukaryotic cells requires a time-dependent export and maturation of filamentous hemagglutinin. Proc Natl Acad Sci USA 90, 9204-9208.
3. Biska, J. B., Galan, J. E. & Falkow, S. (1993). Signal transaction in the mammalian cell during bacterial attachment and entry. Cell 73, 920.
4. Chaby, R. & Caroff, M. (1988). Lipopolysaccharides of Bordetella pertussis endotoxin. In Pathogenesis and Immunity in Pertussis, pp. 247-271. Edited by A. C. Wardlaw & R. Parton. Chichester: John Wiley.
5. Charles, I. G., Dougan, G., Pickard, D., Chatfield, S., Smith, M., Novotny, P., Morrissey, P. & Fairweather, N. F. (1989). Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc Natl Acad Sci USA 86, 3554-3558.
6. Charles, I. G., Li, J., Roberts, M., Beesley, K., Romanos, M., Pickard, D. J., Francis, M., Campbell, D., Dougan, G., Brennan, M. J., Manclark, C. R., Jensen, M. A., Heron, I., Chubb, A., Novotny, P. & Fairweather, N. F. (1991). Identification and characterization of a protective immunodominant b cell epitope of pertactin (P.69) from Bordetella pertussis. Eur J Immunol 21, 1147-1153.
7. Charles, I., Fairweather, N., Pickard, D., Beesley, J., Anderson, R., Dougan, G. & Roberts, M. (1994). Expression of the Bordetella pertussis P.69 pertactin adhesin in Escherichia coli: fate of the carboxy-terminal domain. Microbiology 140, 3301-3308.
8. Cohen, S. M. & Wheeler, M. W. (1946). Pertussis vaccine prepared from phase 1 cultures grown in fluid medium. Am J Public Health 36, 371-377.
9. Davis, R. W., Botstein, D. & Roth, J. R. (1980). Advanced Bacterial Genetics. A Manual for Genetic Engineering. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
10. Friedman, R. L., Nordensson, K., Wilson, L., Akporiaye, E. T. & Yocum, D. E. (1992). Uptake and intracellular survival of Bordetella pertussis in human macrophages. Infect Immun 60, 4578-4585.
11. Furste, J. P., Pansagrau, W., Frank, R., Blocker, H., Scholtz, P., Bagdasarian, M. & Lanka, E. (1986). Molecular cloning of plasmid RP4 primase region in a multi-host-range tacP expression vector. Gene 48, 119-131.
12. Hynes, R. O. (1987). Integrins: a family of cell surface receptors. Cell 48, 549-554.
13. Isberg, R. R. & Falkow, S. (1996). A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured epithelial cells. Nature 317, 262-264,
14. Knapp, S. & Mekalanos, J. J. (1988). Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis. J Bacteriol 170, 5059-5066.
15. Leininger, E., Roberts, M., Kenimer, J. G., Charles, I. G., Fairweather, N., Novotny, P. & Brennan, M. J. (1991). Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells. Proc Natl Acad Sci USA 88, 345-349.
16. Leininger, E., Ewanowich, C. A., Bhargava, A., Peppler, M. S., Kenimer, J. G. & Brennan, M. J. (1992). Comparative roles of the Arg-Gly-Asp sequence present in the Bordetella pertussis adhesins pertactin and filamentous hemagglutinin. Infect Immun 60, 2380-2385.
17. Locht, C., Bertin, P., Menozzi, F. D. & Renauld, G. (1993). The filamentous haemagglutinin, a multifaceted adhesin produced by virulent Bordetella spp. Mol Microbiol 9, 653-660.
18. Makoff, A. J., Oxer, M. D., Ballantine, S. P., Fairweather, N. F. & Charles, I. G. (1990). Protective surface antigen p69 of Bordetella pertussis: its characterization and very high level expression in Escherichia coli. Bio/Technology 8, 1030-1033.
19. Marwick, M. (1996). Acellular pertussis vaccine hailed for infants. J Am Med Assoc 274, 446-447.
20. Mooi, F. R., Jansen, W. H., Brunings, H., Gielen, H., Van der Heide, H. G. J., Walvoort, H. C. & Guinee, P. A. M. (1992). Construction and analysis of Bordetella pertussis mutants defective in the production of fimbriae. Microb Pathog 12, 127-135.
21. Novotny, P., Chubb, A. P., Cownley, K. & Charles, I. G. (1991). Biologic and protective properties of the 69-kda outer membrane protein of Bordetella pertussis: a novel formulation for an acellular pertussis vaccine. J Infect Dis 164, 114-122.
22. Poland, G. A. (1996). Acellular pertussis vaccines: new vaccines for an old disease. Lancet 347, 209-210.
23. Rappuoli, R. (1994). Pathogenicity mechanisms of Bordetella. Curr Top Microbiol Immunol 192, 319-336.
24. Relman, D. A., Domenighini, M., Tuomanen, E., Rappuoli, R. & Falkow, S. (1989). Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Proc Natl Acad Sci USA 86, 2637-2641.
25. Relman, D., Tuomanen, E., Falkow, S., Golenbock, D. T., Saukkonen, K. & Wright S. D. (1990). Recognition of a bacterial adhesin by an integrin: macrophage Cr3 (α(m)β2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Cell 61, 1375-1382.
26. Roberts, M., Fairweather, N. F., Leininger, E., Pickard, D., Hewlett, E. L., Robinson, A., Hayward, C., Dougan, G. & Charles, I. G. (1991). Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein. Mol Microbiol 5, 1393-1404.
27. Roberts, M., Tite, J. P., Fairweather, N. F., Dougan, G. & Charles, I. G. (1992). Recombinant P.69/pertactin: immunogenicity and protection of mice against Bordetella pertussis infection. Vaccine 10, 43-48.
28. Roberts, M., Cropley, I., Chatfield, S. & Dougan, G. (1993). Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA. Vaccine 11, 866-872.
29. Romanos, M. A., Clare, J. J., Beesley, K. M., Rayment, F. B., Ballantine, S. P., Makoff, A. J., Dougan, G., Fairweather, N. F. & Charles, I. G. (1991). Recombinant Bordetella pertussis pertactin (p69) from the yeast Pichia pastoris: high-level production and immunological properties. Vaccine 9, 901-906.
30. Sandros, J. & Tuomanen, E. (1993). Attachment factors of Bordetella pertussis: mimicry of eukaryotic cell recognition molecules. Trends Microbiol 1, 192-196.
31. Shahin, R. D., Brennan, M. J., Li, Z. M., Meade, B. D. & Manclark, C. R. (1990). Characterization of the protective capacity and immunogenicity of the 69-kd outer membrane protein of Bordetella pertussis. J Exp Med 171, 63-73.
32. Strugnell, R., Dougan, G., Chatfield, S., Charles, I., Fairweather, N., Tite, J., Jing Li, L., Beesley, J. & Roberts, M. (1992). Characterization of a Salmonella typhimurium aro vaccine strain expressing the P.69 antigen of Bordetella pertussis. Infect Immun 60, 3994-4002.
33. Tuomanen, E. & Weiss, A. (1985). Characterization of two adhesins of Bordetella pertussis for human ciliated respiratory-epithelial cells. J Infect Dis 152, 118-125.
34. Weiss, A. A., Hewlett, E. L., Myers, G. A. & Falkow, S. (1983). Tn5-induced mutations affecting virulence factors of Bordetella pertussis. Infect Immun 42, 33-41.